Navigation Links
Transcription factor may protect against hepatic injury caused by hepatitis C and alcohol
Date:11/10/2013

Philadelphia, PA, November 11, 2013 New data suggest that the transcription factor FOXO3 may protect against alcohol-induced liver injury. Researchers determined that alcohol given to mice deficient in FOXO3 caused severe liver injury resembling human alcoholic hepatitis. Further they found that although hepatitis C virus (HCV) and alcohol independently activated FOXO3, in combination they suppressed FOXO3, reduced expression of cytoprotective genes, and worsened liver injury. The results are published in The American Journal of Pathology.

"There is emerging evidence that the FOXO transcription factor family plays a critical role in metabolic, antioxidant, and cell death responses in the liver. The role of FOXO in injury processes is complex as FOXO transcription programs can either be cytoprotective or cytotoxic, and well-documented examples of both phenomena are numerous," says Steven A. Weinman, MD, PhD, Department of Internal Medicine at the University of Kansas Medical Center.

Based on such emerging evidence, Dr. Weinman's group fed alcohol to FOXO3-deficient mice for three weeks. One third of these mice developed severe hepatic steatosis (infiltration of liver cells with fat), neutrophil infiltration, and necrosis, similar to that seen in patients with alcoholic hepatitis. In some mice, levels of the liver enzyme alanine aminotransferase (ALT) increased tenfold compared to controls.

Investigators also induced severe liver injury with alcohol in a mouse model of HCV (transgenic HCV/Sod2+/-). These animals had elevated ALT; increased ICAM-1 expression and caspase 3 cleavage, and severe steatosis, lobular inflammation, and ballooning degeneration of liver cells. In these mice, degree of liver injury correlated with levels of the mitochondrial antioxidant enzyme superoxide dismutase (SOD2). (SOD2 is also thought to play a part in protecting the liver from alcoholic injury.) Alcohol-treated HCV/Sod2+/- mice also showed a
'/>"/>

Contact: Eileen Leahy
ajpmedia@elsevier.com
732-238-3628
Elsevier Health Sciences
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Study demonstrates cells can acquire new functions through transcriptional regulatory network
2. Transcription factor Lyl-1 critical in producing early T-cell progenitors
3. NIH backs Rice University study of delay in gene transcription networks
4. Stay-at-home transcription factor prevents neurodegeneration
5. FASEB SRC announces: Mechanism and Regulation of Prokaryotic Transcription Conference
6. Environmental factors in Tiny Tims near fatal illness
7. Soy-based S-equol supplement reduces metabolic syndrome risk factors
8. From scourge to saint: E. coli bacteria becomes a factory - to make cheaper, faster pharmaceuticals
9. Impaired recovery of Atlantic cod -- forage fish or other factors?
10. Longer sleep times may counteract genetic factors related to weight gain
11. Molecule found that inhibits estrogen, key risk factor for endometrial and breast cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... Journal of Medicine reports positive results of a ... the subset of lung cancer marked by rearrangement of ... patients with advanced non-small cell lung cancer testing positive ... percent, with 3 complete responses and 33 partial responses. ... the disease to resume its growth after being slowed ...
(Date:9/30/2014)... research, involving mice and published in the October 2014 ... , suggests that just because you can do ... team of Italian scientists have found that using marijuana ... immune system. This damage may result in autoimmune diseases ... bowel disease and rheumatoid arthritis in adulthood. , "I ...
(Date:9/30/2014)... is available in German . ... behavioural response to risky situations such as exposure to ... now found in a long-term study on different populations ... metabolic rate and ambient temperature. High metabolic rates and ... in these scenarios birds were more likely to approach ...
Breaking Biology News(10 mins):NEJM: Crizotinib effective in Phase 1 trial against ROS1 lung cancer 2Adolescent exposure to thc may cause immune systems to go up in smoke 2Risky metabolism 2
... Can the hold that Intelligent Design theorists have in ... a leading American evolutionist, makes the case for Darwin ... Reporting from the front lines of America's struggle over ... (University College London) on 16th November. , In his ...
... inoculate everyone in the United States could be grown ... plants, a University of Central Florida molecular biologist has ... UCF professor Henry Daniell's laboratory through the genetic engineering ... later by National Institutes of Health researchers. The results ...
... special green-algae gene into neurons of the tiny, ... to elicit specific behavioral responses by simply illuminating ... way for better understanding of how neurons communicate ... behavior in intact, living organisms. Generally speaking, detailed ...
Cached Biology News:'Creationism is not science' ?making the case for Darwin at UCL 2Effective, safe anthrax vaccine can be grown in tobacco plants 2Effective, safe anthrax vaccine can be grown in tobacco plants 3Algal protein in worm neurons allows remote control of behavior by light 2
(Date:9/30/2014)... 30, 2014 Fast, semi-automatic ... chemistry in documents ChemAxon , ... consulting services for life science research, launches ChemCurator, ... Markush structures from documents. Markush structures ... however generating and understanding Markush structures is a ...
(Date:9/30/2014)... 30, 2014 OriginOil Inc. (OTC/QB: OOIL), ... process to clean up large quantities of water, announced ... Eckelberry reported on the launch of the company's CLEAN-FRACâ„¢ ... provided by partner STW Resources . , Immediately ... per day (bpd) and achieved a 99.8% reduction in ...
(Date:9/30/2014)... and ROCKVILLE, Md., Sept. 30, 2014 BioHealth ... on commercializing market-relevant biohealth innovations and increasing access to ... announced today that venture capitalist, Tania Fernandez , ... advisor. Dr. Fernandez will be a member of the ... will provide up to $50 million in seed and ...
(Date:9/30/2014)... September 30, 2014 iLab Solutions announced ... Benchmarking study which focuses on core facility operations, ... core managers face today. , In its 4th year ... of note is the year-over-year decrease in the percentage ... appear to be feeling the constraints of this trend. ...
Breaking Biology Technology:ChemAxon Introduces ChemCurator for Chemical Information Extraction and Markush Structure Creation 2OriginOil, Inc. Report to Shareholders: Blue Gold in West Texas 2Seasoned Life Sciences Venture Capitalist Tania Fernandez Joins BHI to Help Manage New BioHealth Gap Fund 2iLab Solutions Announces the Results of the 2014 Core Facility Benchmarking Study 2iLab Solutions Announces the Results of the 2014 Core Facility Benchmarking Study 3
... Willebrords 1 and Bart Moyson 2 , ... Development, a division of Janssen Pharmaceutica N.V., Laboratory of Virology, Beerse, Belgium ... Life Sciences Benelux NV, Teralfene, Belgium , ... of this paper is to report the performance obtained by dispensing 1μL organic ...
... Jeff Cunningham and Lynn Jordan ... Inc., Applications Laboratory, Hopkinton, Massachusetts, USA , ... The ability to continuously dispense reagents across multi-well plates ... high throughput laboratories. Equally important, however, is the precision that can ...
... , Bruce R. Conklin 1 , Laurence L. Brunton ... Anne T. Ferguson 4 , 1 Gladstone ... Pharmacology 2 and Medicine 3 , ... 4 Molecular Devices Corp., 1311 Orleans Drive, Sunnyvale, CA 94089, , , ...
Cached Biology Technology:96 Well Pipetting Precision Testing Using the Sciclone ALH with a 384 Fixed-Cannula Array 296 Well Pipetting Precision Testing Using the Sciclone ALH with a 384 Fixed-Cannula Array 3Sciclone ALH Bulk Dispense Precision Testing 2Gq-coupled Receptor Assays Using FLEXstation 2Gq-coupled Receptor Assays Using FLEXstation 3Gq-coupled Receptor Assays Using FLEXstation 4Gq-coupled Receptor Assays Using FLEXstation 5Gq-coupled Receptor Assays Using FLEXstation 6Gq-coupled Receptor Assays Using FLEXstation 7
...
Histone H2A Polyclonal Antibody 100 ug affinity purified rabbit polyclonal antibody. Detects ~14 kDa Histone H2A. It does not cross-react with other Histones. Reacts with human/mouse/rat. Performs w...
Contains L-glutamine...
... Protein (PEBP) does not share significant ... PEBP is expressed in the ... muscle, and stomach. One important ... exerting inhibitory activity against several serine ...
Biology Products: