Navigation Links
Transcription factor Lyl-1 critical in producing early T-cell progenitors
Date:7/8/2012

HOUSTON - (July 8, 2012) A transcription factor called Lyl-1 is necessary for production of the earliest cells that can become T-cells, critical cells born in the thymus that coordinate the immune response to cancer or infections, said a consortium of researchers led by those from Baylor College of Medicine (www.bcm.edu) in a report in the journal Nature Immunology.

These earliest progenitors (called early T lineage progenitor cells) are the first cells that can be identified as being on the road to becoming T-cells, said Dr. Margaret Goodell (http://www.bcm.edu/star/index.cfm?pmid=2947), director of the Stem Cells and Regenerative Medicine Center of Baylor College of Medicine. Without Lyl-1, only a few of these early T lineage progenitor cells get made.

"This finding gives us insight into the biology of these progenitor cells," said Goodell, a professor of pediatrics at BCM and a member of the Center for Cell and Gene Therapy at BCM, Texas Children's Hospital and The Methodist Hospital.

Dr. Fabian Zohren, a post-doctoral student in Goodell's laboratory, found that mice lacking the gene for this factor had a T-cell deficiency and in particular, too few of these early progenitor cells.

"It showed that those early T lineage progenitor cells are really dependent on Lyl-1 for their generation," said Goodell, who is also corresponding author of the report. "We think that Lyl-1 controls a program that allows survival and expansion of these critical progenitors."

The finding may have particular import in understanding a form of leukemia known as T-cell acute lymphoblastic leukemia. The researchers found that the forms of the disease that have the worst prognosis are those in which the cancer cells resemble these early T lineage progenitor cells. These cells also have high levels of Lyl-1.

One possibility is the T-cell progenitors in patients with this type of T-cell leukemia continue to express Lyl-1, so continue to be programmed to expand. The excess Lyl-1 prevents the early T lineage progenitor cells from differentiating into active T-cells. Goodell said a recent grant from the Alex's Lemonade Stand Foundation will help test that hypothesis.


'/>"/>

Contact: Glenna Picton
picton@bcm.edu
713-798-4710
Baylor College of Medicine
Source:Eurekalert

Related biology news :

1. Study demonstrates cells can acquire new functions through transcriptional regulatory network
2. A step toward minute factories that produce medicine inside the body
3. Infection biology: The elusive third factor
4. Detector of DNA damage: Structure of a repair factor revealed
5. Some factors that impact islet transplantation explored in Cell Transplantation papers
6. Some factors that impact islet transplantation explored in Cell Transplantation papers
7. Growth factor in stem cells may spur recovery from MS
8. SRI Sarnoffs Iris on the Move® N-Glance™ Identification System Receives Lenel Factory Certification
9. Time, place and how wood is used are factors in carbon emissions from deforestation
10. Molecule found that inhibits estrogen, key risk factor for endometrial and breast cancers
11. Longer sleep times may counteract genetic factors related to weight gain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/16/2016)...   IdentyTechSolutions America LLC , a leading ... and a cutting-edge manufacturer of software and hardware ... seamless, integrated solutions that comprise IDT biometric readers ... provide IdentyTech,s customers with combined physical identification and ... and theft. "We are proud to ...
(Date:12/15/2016)... 2016   WaferGen Bio-systems, Inc. (NASDAQ: ... announced today that on December 13, 2016, it received ... Nasdaq Stock Market LLC which acknowledged that, as of ... common stock had been at $1.00 or greater for ... with Listing Rule 5550(a)(2) of the Nasdaq Stock Market. ...
(Date:12/15/2016)... Dec. 14, 2016 "Increase in mobile transactions ... The mobile biometrics market is expected to grow from ... by 2022, at a CAGR of 29.3% between 2016 ... as the growing demand for smart devices, government initiatives, ... "Software component is expected to grow at a ...
Breaking Biology News(10 mins):
(Date:1/11/2017)... Colo. (PRWEB) , ... January 11, 2017 , ... ... the journal Clinical Cancer Research show early promise of the investigational anti-cancer agent ... despite a median 5 previous treatment regimens. Twenty-seven percent of these heavily pretreated ...
(Date:1/11/2017)... 2017  Brian Mehling, M.D., world-renowned stem cell researcher, ... International (BHI), will be attending the 47th Annual World ... from January 17-20, 2017. This will be Dr. Mehling,s ... theme of this year,s forum is Responsive and Responsible ... address strategies for fostering greater social inclusion and human ...
(Date:1/11/2017)... ... 2017 , ... IsoPlexis Corporation (IsoPlexis), a venture-capital ... the proteomic function of individual cells in patients, today announced it was recently ... National Institute on Aging of the National Institutes of Health to develop a ...
(Date:1/11/2017)... ... January 11, 2017 , ... Advanced Polymer ... its team. Bernhard Bartylla will lead European initiatives for APMT’s product lines serving ... ACOMP and ARGEN to European manufacturers and researchers. Bernhard brings significant experience in ...
Breaking Biology Technology: