Navigation Links
Transcatheter aortic valve implantation shows promise in patients with severe aortic stenosis
Date:4/10/2012

German researchers report success with transcatheter aortic valve implantation (TAVI) in patients with low-flow, low-gradient aortic stenosisa special form of aortic stenosis that is difficult to treat. Results published in the April issue of Catheterization and Cardiovascular Interventions, the peer-reviewed journal of the Society for Cardiovascular Angiography and Interventions (SCAI), show that while all-cause mortality was high within the first six months, TAVI significantly improved heart function and exercise capacity in surviving patients.

While low-flow, low-gradient aortic stenosis occurs in only 5% of patients with aortic stenosis, treatment of these patients remains challenging. Previous research shows a more discouraging prognosis for patients receiving conservative therapy and higher mortality following surgical aortic valve replacement. Over the past few years, TAVI has been used as an alternative treatment for patients with severe aortic stenosis or in those deemed a high surgical risk.

A team led by Dr. Michael Gotzmann, with the University-Hospital Bergmannsheil in Bochum, Germany performed TAVI in 167 consecutive patients with severe aortic stenosis and high operative risk between June 2008 and December 2010. Of those participating, 15 patients had low-flow, low-gradient aortic stenosis and the remaining 152 patients were part of the control group. Interventionists used the Medtronic CoreValve prosthesis 18-F generation for this study.

Within the first 6 months following TAVI, 25 patients died13% without and 33% with low-flow, low-gradient aortic stenosis. These patients had a higher all-cause mortality following TAVI compared to patients without this severe form of disease. However, the surviving 10 patients with low-flow, low-gradient aortic stenosis reached the 6-month mark, and after nearly a year post-procedure no additional death, myocardial infarction, or stroke occurred.

Furthermore, the surviving patients displayed a significant improvement in heart function and exercise capacity. "While there is a high mortality rate in this difficult-to-treat patient group, there is symptomatic benefit for patients undergoing TAVI therapy," said Dr. Gotzmann. The authors suggest the high mortality rate could be due to pre-existing conditions that place patients are greater risk post-procedure. "Further multi-center studies in larger patient populations are needed to understand the potential benefit of TAVI in patients with low-flow, low-gradient aortic stenosis," concludes Dr. Gotzmann.


'/>"/>

Contact: Dawn Peters
healthnews@wiley.com
781-388-8408
Wiley-Blackwell
Source:Eurekalert

Related biology news :

1. UofL physicians, Jewish Hospital first in Kentucky to offer new aortic valve replacement
2. UTHealth, BCM researchers find common gene variant associated with aortic dissection
3. UTHealth discoveries shed more light on deadly thoracic aortic disease
4. Freeze-dried heart valve scaffolds hold promise for heart valve replacement
5. New design for mechanical heart valves
6. Story of lymphatic system expands to include chapter on valve formation
7. Outcomes for cardiac valve procedure patients are affected by insurance status
8. Adjustable valves gave ancient plants the edge
9. Immune system release valve
10. The bivalve effect
11. Study details safe, effective, minimally invasive mitral valve repair
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/19/2016)... Securus Technologies, a leading provider of civil ... corrections and monitoring, announced today that it has offered ... an independent technology judge determine who has the largest ... telephone calling platform, and the best customer service. ... of what we do – which clearly is not ...
(Date:11/17/2016)... Calif. , Nov. 17, 2016  AIC announces that it has just released ... in organizations that require high-performance scale-out plus high speed data transfer storage solutions. ... ... ... Setting up a high ...
(Date:11/15/2016)... Nov. 15, 2016  Synthetic Biologics, Inc. (NYSE ... focused on the gut microbiome, today announced the ... shares of its common stock and warrants to ... a price to the public of $1.00 per ... Biologics from the offering, excluding the proceeds, if ...
Breaking Biology News(10 mins):
(Date:12/7/2016)... ... December 07, 2016 , ... Cambrian ... for industrial facilities, today announced that one of the nation’s fastest growing craft ... novel water-energy purchase agreement (WEPA). Under the WEPA, a first for the industrial ...
(Date:12/6/2016)... -- The American Botanical Council (ABC) recognizes wellness ... Arnica montana ) through ABC,s Adopt-an-Herb program. This ... database, a comprehensive, interactive online tool that provides ... on the uses and health effects of more ... wellness company with healing arts centers, skin and ...
(Date:12/6/2016)... ... December 06, 2016 , ... ... automation and IT solutions, today announced the company has successfully completed its 50th ... executed automation and control systems integration services to leading companies in life sciences, ...
(Date:12/6/2016)... Zimmer Biomet Holdings, Inc. (NYSE and ... terms of its previously-announced cash tender offers (the ... (excluding accrued and unpaid interest to, but not ... and expenses related to the Offers) (the "Maximum ... the table below (collectively, the "Notes"). The terms ...
Breaking Biology Technology: