Navigation Links
Trainor Lab characterizes gene essential for prenatal development of nervous system
Date:2/1/2008

The Stowers Institutes Trainor Lab has demonstrated the role of a gene important to the embryonic development of the nervous system, a process that requires coordination of differentiation of immature neural cells with the cycle of cell division that increases their numbers. Until now, the mechanisms regulating these distinct cellular activities have been poorly understood.

The findings will be published in the Feb. 15 issue of Development.

In this work, the team used gain- and loss-of-function mutations in mice to isolate novel roles for the mouse Cux2 gene in regulating neurogenesis. They established that Cux2 directs neuroblast development, neuronal differentiation, and cell-fate determination in the spinal cord by coupling progression through the cycle of cell division with differentiation of neural cells by direct activation of two key neurogenic determinants, Neurod and p27Kipl.

We were excited to uncover, for the first time, multiple functional roles for a Cux-like homeodomain transcription factor in regulating key aspects of spinal cord neurogenesis, said Angelo Iulianella, Ph.D., Senior Research Associate and first author on the publication. The demonstration that Cux2 integrates cell-cycle progression with neural progenitor differentiation and cell-fate determination provides a much clearer picture of the complex process of neurogenesis.

The impact of cell cycle length on the formation of interneurons versus motoneurons was a surprising finding, said Paul Trainor, Ph.D., Associate Investigator, and senior author on the publication. Ongoing work involves global proteomic analyses aimed at identifying the complete set of Cux2-interacting partners. We believe these efforts will be essential to understanding how Cux2 elicits its multiple functions during neurogenesis.

Further analysis of Cux2 will make it possible to extend these findings not only to spinal cord development, but also to the mammalian cortex, where Cux genes demarcate specific upper layers of cortical neurons and may have played a role in the expansion and increased complexity of the cortex during evolution.


'/>"/>

Contact: Marie Jennings
mfj@stowers-institute.org
816-926-4015
Stowers Institute for Medical Research
Source:Eurekalert

Related biology news :

1. Xie Lab characterizes niche control of stem cell function
2. Earth Observation essential for geohazard mitigation
3. ESA to provide essential launch control services to EUMETSAT
4. How did chemical constituents essential to life arise on primitive Earth?
5. Study shows vitamin C is essential for plant growth
6. MIT: Prenatal arsenic exposure detected in newborns
7. Study of successful drug targets could hasten development of new medications
8. Search for the on switches may reveal genetic role in development and disease
9. Gene Networks in Animal Development and Evolution Feb. 15 and 16
10. Research pioneer in the developmental origins of psychiatric illness is awarded the Sackler prize
11. St. Jude defines eye cancer genes role in retinal development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/22/2016)... Md. , June 22, 2016  The American College ... Trade Show Executive Magazine as one of the ... on May 25-27 at the Bellagio in Las ... on the highest percentage of growth in each of the ... of exhibiting companies and number of attendees. The 2015 ACMG ...
(Date:6/21/2016)... VANCOUVER, British Columbia , June 21, 2016 ... been appointed to the new role of principal ... has been named the director of customer development. ... , NuData,s chief technical officer. The moves reflect ... development teams in response to high customer demand ...
(Date:6/15/2016)... York , June 15, 2016 ... new market report titled "Gesture Recognition Market by Application ... Forecast, 2016 - 2024". According to the report, the  ... 11.60 billion in 2015 and is estimated to ... USD 48.56 billion by 2024.  Increasing ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , ... June 23, 2016 , ... ... release of its second eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering ... retention in this eBook by providing practical tips, tools, and strategies for clinical ...
(Date:6/23/2016)... , June 23, 2016 Houston Methodist ... the Cy-Fair Sports Association to serve as their ... agreement, Houston Methodist Willowbrook will provide sponsorship support, ... connectivity with association coaches, volunteers, athletes and families. ... the Cy-Fair Sports Association and to bring Houston ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... today announced the launch of the Supplyframe Design Lab . Located in ... to explore the future of how hardware projects are designed, built and brought ...
(Date:6/23/2016)... , June 23, 2016 ... Hematology Review, 2016;12(1):22-8 http://doi.org/10.17925/OHR.2016.12.01.22 ... , the peer-reviewed journal from touchONCOLOGY, Andrew ... escalating cost of cancer care is placing an ... result of expensive biologic therapies. With the patents ...
Breaking Biology Technology: