Navigation Links
Training cells to perform Boolean functions? It's logical
Date:5/31/2012

Johns Hopkins scientists have engineered cells that behave like AND and OR Boolean logic gates, producing an output based on one or more unique inputs. This feat, published in the May issue of Nature Chemical Biology, could eventually help researchers create computers that use cells as tiny circuits.

Study leader Takanari Inoue, Ph.D., an assistant professor in the Department of Cell Biology and member of the Institute of Basic Biomedical Sciences' Center for Cell Dynamics at the Johns Hopkins University School of Medicine, explains that many researchers are striving to mimic devices in everyday use by engineering new qualities into biological materials, including biomolecules and cells. Several of those engaged in this relatively new field, known as synthetic biology, have tried to create biological computers.

At the heart of both the biological and the more everyday silicon-based variety of computers are Boolean logic gates, which produce responses that vary depending on what type and how many inputs they receive. For example, AND gates need two unique inputs to generate an output. In contrast, OR gates generate an output based on whether they receive one input, or another, or both.

Inoue says that previous research has shown some success in generating logic gates based on biomolecules in test tubes or petri dishes. However, he adds, developing logic gates using whole cells has proven significantly trickier. Most previous efforts have taken advantage of cells' transcriptional machinery the cellular processes that read genes to create proteins to generate an output signal. But transcription can be a slow process, taking from minutes to days to produce the desired response.

"People like to have speedy computation," Inoue says. "We were hoping to achieve computation in cells on the order of seconds, which is significantly faster than what people have achieved thus far."

To accomplish their goal, the resear
'/>"/>

Contact: Audrey Huang
audrey@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Researchers develop new self-training gene prediction program for fungi
2. NC State takes lead in crime scene investigation training
3. National and international doctoral training
4. Virtual reality: Keyhole surgeons training could help meet European working time directives
5. Biophysical sciences program receives $2 million training grant
6. Building strong bones: Running may provide more benefits than resistance training, MU study finds
7. Stimulus-funded university research addressing issues from climate change to cancer, creating jobs and training a new generation of scientists
8. Concordia University to build innovative centre for health research and training
9. Kent State receives $2.7 million NSF training grant for environmental aquatic resource sensing
10. Rockefeller Foundation supports expansion, training of e-health work force in developing world
11. Less is more when restraining calories boosts immunity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2015)... Calif. , July 13, 2015 ... developer of human interface solutions, today announced sampling ... touch and display driver integration (TDDI) product targeting ... the first to combine Synaptics , best-in-class ... proven display driver technology developed in the company,s ...
(Date:7/9/2015)... , July 9, 2015  Synaptics ... developer of human interface solutions, today announced ... industry,s first fully hardware encapsulated fingerprint sensor ... authentication technology is literally off the grid, ... biometric matching within the fingerprint sensor to ...
(Date:7/7/2015)... , June 30, 2015 ... has announced the addition of the "Capacitive ... offering. To this date, fingerprint sensing ... technology and fingerprint sensors are well developed. This ... sensing technology. The domain of capacitive ...
Breaking Biology News(10 mins):Synaptics Announces Sampling of Second Generation TDDI Solutions 2Synaptics Announces Sampling of Second Generation TDDI Solutions 3Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 2Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 3Worldwide Capacitive Fingerprint Sensors Patent Landscape Market Report 2015-2020 - Main IP Holders include Seiko Epson, AuthenTec, Sony and STMicroelectronics 2
... battle between the bacterial pathogen Salmonella and the ... at the Biozentrum of the University of Basel has now ... host,s immune system. Their findings are published in the scientific ... is a bacterial infection caused by the pathogen Salmonella ...
... atom located in the vicinity of a molecule can change ... international team of researchers was able to change persistently positions ... by approaching a single copper atom to the molecule. ... simple organic molecule can be switched by approaching a single ...
... or the pipes of an organ, the proteins in the ... Now, a new study provides what researchers say is ... a technique they developed based on terahertz near-field microscopy, scientists ... (HWI) have for the first time observed in detail the ...
Cached Biology News:Typhoid fever -- A race against time 22-proton bit controlled by a single copper atom 22-proton bit controlled by a single copper atom 3The symphony of life, revealed 2The symphony of life, revealed 3
(Date:8/3/2015)... 2015  Aethlon Medical, Inc. (Nasdaq: AEMD ), ... life-threatening diseases, today announced that it will host its ... on Thursday, August 13, 2015 at 4:30 p.m. Eastern ... the release of fiscal 2016 first quarter results.  A ... two hours after the call at the Investor Relations ...
(Date:8/3/2015)... , Aug. 3, 2015 /PRNewswire/ - RepliCel Life Sciences ... company focused on the development of autologous cell therapies, announced ... presenting at the InvestMNT conference held in Minneapolis, ... AM local time. Hall,s presentation will highlight RepliCel,s 18-month milestones ... in Europe , clinical data from both ...
(Date:7/31/2015)... HONG KONG , July 31, 2015 ... "Company"), China,s leading provider of ... and stem cell storage services, today announced that the ... with the U.S. Securities and Exchange Commission. The filed ... year ended March 31, 2015. The Form 20-F can ...
(Date:7/30/2015)... Mass. , July 30, 2015   ... solutions for the interpretation and analysis of genomic ... Matthew Fischer has joined the company as ... Photo - http://photos.prnewswire.com/prnh/20150730/250931 ... capabilities to integrate, interpret, analyze and explore complex ...
Breaking Biology Technology:Aethlon Medical To Host First Quarter Fiscal 2016 Investor Call on August 13, 2015 2RepliCel Presenting at InvestMNT Investor Conference in Minneapolis 2China Cord Blood Corporation Files Its Annual Report on Form 20-F 2GenoSpace Introduces Matthew Fischer as Vice President of Sales and Marketing 2
... Inc., (NYSE: CRY ),a biomaterials, medical device ... first CryoValve(R) SG pulmonary human heart,valve since the ... Administration,(FDA) in February. The procedure was performed on ... Louis, Mo. The CryoValve SG is processed with,the ...
... RepHresh,Vaginal Gel(R) is now available to women in Canada., ... to educate women about their,feminine health, RepHresh Vaginal Gel ... comes to discussing a highly volatile and often,embarrassing subject, ... a successful dialogue between women,doctors, and the media that ...
... for clean water stretches even the resources of the world,s ... technology and novel ideas to find solutions. , Mark Shannon ... of world leaders in water resource research to address this ... issue of Nature. , "As dire as the growing problems ...
Cached Biology Technology:CryoLife Announces Implant of First FDA-Cleared SynerGraft(R) Processed Human Pulmonary Heart Valve 2CryoLife Announces Implant of First FDA-Cleared SynerGraft(R) Processed Human Pulmonary Heart Valve 3pH Balanced RepHresh Vaginal Gel(R) now Available to Women in Canada Attacking Tough, Embarrassing Feminine Issues 2pH Balanced RepHresh Vaginal Gel(R) now Available to Women in Canada Attacking Tough, Embarrassing Feminine Issues 3Countering an approaching water crisis 2
Ideally suited for resolving DNA and RNA 10-1000 bases especially PCR products ranging from 100-1000 bp. Gelling temp. (4%) 27C Melting temperature 65C. EEO: 0.10 Rnase/Dnase: none detected...
XEDAR Antibody...
Xanthine Oxidase (Bovine Buttermilk). Monospecific by IEP. Some cross reactivity with Xanthine Oxidase of other species and tissues may occur....
Rabbit Anti-JNK1/SAPK pan, Polyclonal Antibody...
Biology Products: