Navigation Links
Tracking the evolution of antibiotic resistance
Date:2/1/2013

Philadelphia, Pa. With the discovery of antibiotics, medicine acquired power on a scale never before possible to protect health, save lives, and reduce suffering caused by certain bacteria. But the power of antibiotics is now under siege because some virulent infections no longer respond to antibiotic drugs.

This antibiotic resistance is an urgent public health threat that a team of researchers from Sabanci University in Istanbul, Turkey, and Harvard Medical School and Harvard University in Cambridge, Mass., aim to stop. Their approach is based on an automated device they created that yields a new understanding of how antibiotic resistance evolves at the genetic level. The team will present its work at the 57th Annual Meeting of the Biophysical Society (BPS), held Feb. 2-6, 2013, in Philadelphia, Pa.

Called the "morbidostat," the device grows bacteria in various concentrations of antibiotic. This enabled researchers to identify the concentrations at which the antibiotics stopped working and the bacteria became resistant to therapy. Next, they targeted key genes involved in creating the drug-resistant states. Their approach documented real-time changes in genes that gave bacteria an advantage in evolving to "outwit" antibiotics.

Knowledge at the gene level can be applied to the molecular design of the next generation of bacteria-killing antibiotics.

"Morbidostat is designed to evolve bacteria in conditions comparable with clinical settings," explains Erdal Toprak of Sabanci University. "Combined with next generation genome sequencing technologies, it is possible to follow the evolution of resistance in real time and identify resistance-conferring genetic changes that accumulate in the bacterial genome."

Data show an unusual survival profile of the common bacteria they used, Escherichia coli. "We identified striking features in the evolution of resistance to the antibiotic trimethoprim," Toprak says. It was these unusual features that helped them isolate the gene involved in conferring antibiotic resistance through multiple mutations.

The team's next steps will involve determining how this genetic information might one day be applied to drug design to develop new antibiotic therapies.


'/>"/>

Contact: Ellen R. Weiss
eweiss@biophysics.org
240-290-5606
American Institute of Physics
Source:Eurekalert

Related biology news :

1. UC research: Tracking Lake Erie water snake in fight against invasive fish
2. Genetic markers for tracking species
3. Elephant seal tracking reveals hidden lives of deep-diving animals
4. uAttend Time Tracking Solutions Available at TimeClockDeals.com
5. Probing the roots of depression by tracking serotonin regulation at a new level
6. Tracking the effects of prenatal alcohol exposure through to 9 years of age
7. Vitamin B12 deficiency: Tracking the genetic causes
8. Tracking shuttle exhaust reveals more information about atmospheric winds
9. Tracking fish through a coral reef seascape
10. TB outbreaks could be solved by DNA tracking
11. Precision motion tracking -- thousands of cells at a time
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/2/2016)... VIEW, Calif. , Feb. 2, 2016 /PRNewswire/ ... retinopathy market, Frost & Sullivan recognizes US-based Intelligent ... America Frost & Sullivan Award for New Product ... provider in North America , ... in the rapidly growing diabetic retinopathy market. The ...
(Date:1/27/2016)... 2016  Rite Track, Inc. a leading semiconductor equipment ... Chester, Ohio announced today the acquisition of PLUS ... in Austin, Texas , will significantly ... modifications, installations and technical support offerings for TEL Track ... commented, "PLUS has provided world class service including refurbishment, ...
(Date:1/21/2016)... 21, 2016 --> ... market research report "Emotion Detection and Recognition Market by Technology ... (Facial Expression, Voice Recognition and Others), Services, Application ... to 2020", published by MarketsandMarkets, the global Emotion ... USD 22.65 Billion by 2020, at a CAGR ...
Breaking Biology News(10 mins):
(Date:2/5/2016)... , February 5, 2016 Amarantus ... biotechnology company focused on developing products for Regenerative Medicine, ... Rare Pediatric Disease Designation (RPDD) from the US Food ... with MANF. MANF was previously granted orphan drug designation ... --> Amarantus BioScience Holdings, Inc. (OTCQB: ...
(Date:2/4/2016)... Francisco, CA (PRWEB) , ... February 04, 2016 ... ... of enterprise talent development and compliance training, today announced an interactive FDA ... Morf Playbook™. The RAPS (Regulatory Affairs Professional Society) accredited interactive course on ...
(Date:2/4/2016)... 2016  Sangamo BioSciences, Inc. (NASDAQ: SGMO ), ... Edward Lanphier , Sangamo,s president and chief executive ... Sangamo,s ZFP Therapeutic ® development programs and an ... ET on Thursday, February 11, 2016, at the Leerink ... conference is being held in New York ...
(Date:2/4/2016)... ... February 04, 2016 , ... ... Forensics Club, takes place February 5-6 at the University’s student center, Kehr ... activities such as workshops and competitions for ample networking, learning and collaborating ...
Breaking Biology Technology: