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Tracking prions
Date:6/17/2008

d -sheet structure, but up close the structures diverge widely. Particularly striking is the fact that the infectious pH 7 form has highly flexible loops in addition to the rigid domains. These are absent from the non-infectious pH 3 prions.

"The lack of infectiousness of the pH 3 fibrils is thus related to the fact that their molecular structure is significantly different from that of the fibrils formed at physiological pH," the researchers conclude.


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Contact: Beat Meier
beat.meier@nmr.phys.chem.ethz.ch
41-446-324-401
Wiley-Blackwell
Source:Eurekalert  

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Tracking prions
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