Navigation Links
Tracking prions
Date:6/17/2008

This release is available in German.

Infectious proteins known as prions have been identified as the cause of "mad cow" disease (BSE). The culprits are "incorrectly folded" proteins that can "infect" healthy proteins. The molecular bases for such prion diseases are not yet fully understood. Why are some proteins infectious while others are not? A team headed by Beat Meier (ETH Zurich, Switzerland) and Raimon Sabat (University of Bordeaux, France) has examined two different forms of a prion-forming protein domain by means of NMR spectroscopy. In the journal Angewandte Chemie, the researchers report that the infectious and non-infectious forms differ markedly in their molecular structure.

The word prion is derived from the term Proteinaceous Infectious Particle. These are proteins that can fold in different ways. Pathogenic prions are dangerous because they can convert physiological, non-pathogenic molecules into the diseased form. Often, prions largely consist of -sheet structures. These are accordion-like folded protein ribbons that can easily aggregate into thread-like structures (amyloid fibrils).

The research team took on the prion-forming domain of the fungal protein HET-s. At a pH value of 7under physiological conditionsthis domain forms infectious fibrils. In acidic solution, at pH 3, it also forms fibrils, but these are not infectious.

By using nuclear magnetic resonance spectroscopy (NMR), the team was able to get a closer look at this protein. NMR allows for the evaluation of interactions of the nuclear spins of specific atomic nuclei with each other and their chemical surroundings, which gives information about the structure and dynamics of molecules and molecular fragments.

Here's what the researchers found: The spectra of the pH 7 and pH 3 versions of the prion differ significantly. Both are mainly arranged in the rigi
'/>"/>

Contact: Beat Meier
beat.meier@nmr.phys.chem.ethz.ch
41-446-324-401
Wiley-Blackwell
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Tracking feline memories on the move
2. Louisiana Tech researchers investigate tracking, sensors to assist Air Force
3. NIH recognizes Clemson nanotechnology for molecule tracking
4. GestureTek/Imagination Launch AirPoint, Worlds First Hand-Tracking Unit, for Shell Group.
5. Tracking stroke
6. Tracking influenzas every movement
7. Prions and retroviruses -- an unholy alliance?
8. Prions show their good side
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Tracking prions
(Date:1/22/2015)... WINSTON-SALEM, N.C. , Jan. 16, 2015  A man-made ... working memory and other mental capabilities in adults with ... a pilot study led by researchers at Wake Forest ... 60 adults diagnosed with amnesic mild cognitive impairment (MCI) ...
(Date:1/22/2015)... , Jan. 22, 2015 Research and Markets ... of the "Global Wearable Technologies Market and ... Overview, Trends and Forecast 2014-2020" report to ... are smart devices that can be worn on ...
(Date:12/22/2014)... Dec. 22, 2014 Research and Markets ... the "The Global Watermarking and Fingerprinting Markets" ... http://photos.prnewswire.com/prnh/20130307/600769 This insight ... watermarking and fingerprinting markets. Watermarking aims to control ...
Breaking Biology News(10 mins):Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 2Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 3Global Wearable Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, Size, Growth, Share, Overview, Trends and Forecast 2014-2020 2The Global Watermarking and Fingerprinting Markets 2
... at UC Santa Barbara have discovered a caste of ... fluke species that invades the California horn snail. The ... the Proceedings of the Royal Society B . ... killer morphs defending the colony," said Armand M. Kuris, ...
... Menachem Shoham, PhD, associate professor and researcher in ... University School of Medicine, has identified new anti-pathogenic drugs ... Aureus (MRSA) harmless by preventing the production of toxins ... a growing public health problem causing 20,000 deaths per ...
... the support of an $11.8 million, five-year federal grant, ... are developing a quick-dissolving vaginal film containing a powerful ... they plan to begin testing it locally within a ... deliver breath fresheners, could have several advantages over vaginal ...
Cached Biology News:'Warrior worms' discovered in snails; UCSB scientists see possible biomedical applications 2Case Western Reserve researcher discovers new 'anti-pathogenic' drugs to treat MRSA 2Pitt gets $11.8 million to develop microbicide films for HIV prevention 2
(Date:1/22/2015)... Protocol Networks brings independent technology consulting to ... independent consultants, Protocol Networks has recently announced its expansion ... years, his company has attracted several clients in The ... well as others. With the success of these engagements, ...
(Date:1/22/2015)... 2015 zFlo Motion , a US ... an exciting product from a new partner. STT-Systems ... the past 15 years, with offerings in the optical-motion capture, ... IMU system (inertial measurement unit), iSen, is opening eyes around ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Selexis SA, ... mammalian Research Cell Banks (RCBs) used for drug discovery ... Cell Banks will include Next-Generation Sequencing (NGS) ... architecture de-risks biologic manufacturing by ensuring the integrity of ...
(Date:1/22/2015)... , Jan. 22, 2015   Cypher Genomics, ... Sequenom, Inc. (NASDAQ: SQNM ), the ... agreement for next generation noninvasive prenatal tests (NIPT). ... interpretation technology, called Mantis™, to advance analysis of ...
Breaking Biology Technology:Protocol Networks Brings Independent Technology Consulting to the Constitution State 23D Motion Capture Just Got Easy 2Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4
... 21, 2010 The Pharmaceuticals practice,at MarketsandMarkets is pleased to announce a ... , , ... Calorie/Diet Beverages Market (2010,-2015)Market Report. Early buyers will receive 10% customization of reports, ... ...
... ... today announced an agreement under which Therapure will provide manufacturing ... Israel with an executive management team based in Woburn, MA. Under ... clinical manufacturing for one of ProChon’s products, which may be used ...
... Minnesota-led researchers has cleared a major hurdle in the drive ... as high as current levels, which rarely exceed 30 percent. ... from semiconductors in solar cells can be captured and transferred ... for solar cell researchers seeking to build cheaper, more efficient ...
Cached Biology Technology:World Low Calorie/Diet Beverages Market (2010 -2015): MarketsandMarkets 2World Low Calorie/Diet Beverages Market (2010 -2015): MarketsandMarkets 3Therapure Biopharma Inc. Signs Biomanufacturing Contract with ProChon Biotech Ltd. 2University of Minnesota researchers clear major hurdle in road to high-efficiency solar cells 2
Recombinant Mouse MMP-9, CF...
Viral CMV UL146/vCXC1 Biotinylated Affinity Purified PAb...
Cyan Standard is 7-hydroxy-4-trifluoromethylcoumarin...
... High Sensitivity Freezing Point Osmometer for 10 L sample. Ideal for small volume applications, including pediatric, ... Ready to run in less than 3 minutes after turn-on. ... ... ...
Biology Products: