Navigation Links
Tracking prions
Date:6/17/2008

This release is available in German.

Infectious proteins known as prions have been identified as the cause of "mad cow" disease (BSE). The culprits are "incorrectly folded" proteins that can "infect" healthy proteins. The molecular bases for such prion diseases are not yet fully understood. Why are some proteins infectious while others are not? A team headed by Beat Meier (ETH Zurich, Switzerland) and Raimon Sabat (University of Bordeaux, France) has examined two different forms of a prion-forming protein domain by means of NMR spectroscopy. In the journal Angewandte Chemie, the researchers report that the infectious and non-infectious forms differ markedly in their molecular structure.

The word prion is derived from the term Proteinaceous Infectious Particle. These are proteins that can fold in different ways. Pathogenic prions are dangerous because they can convert physiological, non-pathogenic molecules into the diseased form. Often, prions largely consist of -sheet structures. These are accordion-like folded protein ribbons that can easily aggregate into thread-like structures (amyloid fibrils).

The research team took on the prion-forming domain of the fungal protein HET-s. At a pH value of 7under physiological conditionsthis domain forms infectious fibrils. In acidic solution, at pH 3, it also forms fibrils, but these are not infectious.

By using nuclear magnetic resonance spectroscopy (NMR), the team was able to get a closer look at this protein. NMR allows for the evaluation of interactions of the nuclear spins of specific atomic nuclei with each other and their chemical surroundings, which gives information about the structure and dynamics of molecules and molecular fragments.

Here's what the researchers found: The spectra of the pH 7 and pH 3 versions of the prion differ significantly. Both are mainly arranged in the rigi
'/>"/>

Contact: Beat Meier
beat.meier@nmr.phys.chem.ethz.ch
41-446-324-401
Wiley-Blackwell
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Tracking feline memories on the move
2. Louisiana Tech researchers investigate tracking, sensors to assist Air Force
3. NIH recognizes Clemson nanotechnology for molecule tracking
4. GestureTek/Imagination Launch AirPoint, Worlds First Hand-Tracking Unit, for Shell Group.
5. Tracking stroke
6. Tracking influenzas every movement
7. Prions and retroviruses -- an unholy alliance?
8. Prions show their good side
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Tracking prions
(Date:8/10/2015)... August 10, 2015 The latest 364 ... comprehensive analysis of the global border security market . ... of $16.4bn in 2015. Now: Border security is ... example of the business critical issue you need to know ... visiongain ,s objective analysis of how this will impact your ...
(Date:8/6/2015)... Aug. 6, 2015 Synaptics Inc. (NASDAQ: ... interface solutions, today announced collaboration with Microsoft on ... 10. Microsoft leveraged Synaptics, deep expertise in human ... Through stringent testing, Synaptics, advanced ... with Microsoft,s Precision TouchPad (PTP) specification empowering OEMs ...
(Date:8/5/2015)... The biosensors market is proving highly attractive ... newer sectors, and development of devices resulting in higher ... seen the entry of multiple participants each year with ... (Photo - http://photos.prnewswire.com/prnh/20150805/255570 ) Recent ... Global Biosensors Market ( http://www.frost.com/nee9 ), finds that ...
Breaking Biology News(10 mins):Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 2Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 3Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 4Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 5Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 6Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 7Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 8Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 9Synaptics Chosen for Human Interface Co-Development on Windows 10 2Innovative Biosensors Incite Use in Non-Traditional Applications 2Innovative Biosensors Incite Use in Non-Traditional Applications 3Innovative Biosensors Incite Use in Non-Traditional Applications 4
... run electrical current through tiny molecular wires have discovered ... are key to understanding how the bacteria do chemistry ... in microbial fuel cells, batteries, or for turning waste ... groups called hemes communicate with each other to allow ...
... in two distinct communities in Colombia illustrates how coevolution between ... Working with colleagues in Columbia and the U.S., Scott ... of Medicine at Dartmouth, and his graduate student Nuri Kodaman ... on both the ancestry of the person and the ancestry ...
... oyster native to the West Coast could face a double ... research from the University of California, Davis, Bodega Marine Laboratory. ... Proceedings of the Royal Society B . Invasive snails ... snails were raised under ocean conditions forecast for the end ...
Cached Biology News:Hugging hemes help electrons hop 2Hugging hemes help electrons hop 3Hugging hemes help electrons hop 4Researchers discover that coevolution between humans and bacteria reduces gastric cancer risk 2Researchers discover that coevolution between humans and bacteria reduces gastric cancer risk 3Acidification, predators pose double threat to oysters 2
(Date:8/31/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/cbgl72/middle_east_and ) ... & Africa Biomedical Sensors Market - Growth, Trends & ... The Middle East & ... by 2018 at a CAGR of 3.26% over the ... Biomedical sensors that are adaptable to the genetic formulation ...
(Date:8/31/2015)... 2015  RXi Pharmaceuticals Corporation (NASDAQ: RXII ... developing innovative therapies primarily in the areas of ... review period following the filing of the Company,s ... the U.S. Food and Drug Administration (FDA) has ... Logo -  http://photos.prnewswire.com/prnh/20130917/NE80755LOGO ...
(Date:8/31/2015)... FRANCISCO, Calif. , Aug. 31, 2015 ... discovery and development of novel cancer immunotherapies, announced today ... Ph.D., as Chief Executive Officer and William Ho ... and Ho join an experienced management team led by ... Jordan Fridman , Ph.D., Chief Scientific Officer; Jay ...
(Date:8/31/2015)... ... August 31, 2015 , ... Regulatory agencies ... the drug development approval process. Thus, innovator companies must understand what will be ... a Chicago-based CMO, has been hosting multiple educational panels and seminars for experts ...
Breaking Biology Technology:Middle East & Africa Biomedical Sensors Market Report 2015 - Growth, Trends & Forecasts to 2020 2RXi Pharmaceuticals Announces Advancements in its Ophthalmology Clinical Program with RXI-109 2RXi Pharmaceuticals Announces Advancements in its Ophthalmology Clinical Program with RXI-109 3RXi Pharmaceuticals Announces Advancements in its Ophthalmology Clinical Program with RXI-109 4FLX Bio Announces Senior Management Hires and Initiation of Phase 1 Trial of FLX925 2FLX Bio Announces Senior Management Hires and Initiation of Phase 1 Trial of FLX925 3FLX Bio Announces Senior Management Hires and Initiation of Phase 1 Trial of FLX925 4Regis Shares Expert Advice on Impurities in Drug Development 2Regis Shares Expert Advice on Impurities in Drug Development 3
... N.J., June 24 International Products Corporation,s ( ... of performing filter membrane compatibility and ... have the ability to evaluate any type of membrane media, ... says President, Kathy Wyrofsky. "Our goal is to be ...
... - Melogliptin continues to demonstrate potential to be the, ... hypoglycemia and neutral effect on body weight, - ... - IND approved by USFDA, - Glenmark takes a step ... have a truly global innovative drug for the world, , ...
... , AMSTERDAM, The Netherlands, June ... Laboratory has signed an agreement,with Avantium to enable the ... reactor system. The Flowrence(TM) will allow PNNL to,accelerate its ... PNNL is operated by Battelle for ...
Cached Biology Technology:International Products Corp.'s Lab Offers Filter Membrane Compatibility and Studies 2Glenmark's Novel Molecule for Diabetes, Melogliptin to Enter Phase III Trials 2Avantium to Deliver Flowrence System to Pacific Northwest National Laboratory (PNNL), USA 2