Navigation Links
Tracing biological pathways
Date:11/4/2011

und's synthesis, eliminating concerns about the extremely short, two-hour half-life of the fluorine isotope used as a tracer.

Ritter's process begins with fluoride, which is chemically altered to create an intermediate molecule, called an "electrophilic fluorination reagent." Armed with that reagent, and using the late-stage fluorination process developed in Ritter's lab, his team is then able to create fluorinated molecules for use in PET imaging.

The breakthrough opens the door to pharmaceutical companies using the relatively simple, non-invasive scans to track how "micro-doses" of drugs behave in living subjects, with the potential payoff coming in vastly more efficient and cheaper drug development.

"One of the most immediate applications of this is in using molecular imaging to give us an understanding of the bio-distribution of a drug," Ritter said. "If a pharmaceutical company is developing a drug to treat schizophrenia, they could use this test to see if it enters the brain. If early tests show it doesn't, they would be able to kill the project before spending a great deal of time and money on it."

The technique could even be used to unlock the physical traits of disorders that until now have been limited to phenomenological descriptions. Using biomarkers related to specific disorders, researchers could use fluorination to identify biological differences between schizophrenia and bipolar disorder, and use that information to develop treatments for both.

"I don't know if we're ever going to reach that point," Ritter said. "But that's what this project may be able to deliver in the long term. The way my group works we want to solve big problems, and we're willing to sacrifice to get there. This is one problem that is worth a little bit of sweat."


'/>"/>

Contact: Peter Reuell
preuell@fas.harvard.edu
617-496-8070

Source:Eurekalert

Page: 1 2

Related biology news :

1. BGI and Collaborators Announce New Clues Found in Tracing the Origin of the Deadly E. coli Strain and Appeal for the Sharing of Additional Data
2. Tracing microbes between individuals towards personalized oral health care
3. Tracing natural hazards by taking Earths pulse
4. 3-D long-term bone marrow culture to analyze stromal cell biological function
5. $10 million grant supports biological sciences team at University of Nevada, Reno
6. Potential new drugs plug brains biological vacuum cleaner and target HIV
7. Market transactions and economics in general affect biological invasions
8. Alarm clock gene explains wake-up function of biological clock
9. Possible biological control discovered for pathogen devastating amphibians
10. Biological communities studied at historical WWII shipwrecks along North Carolina
11. Regenerative powers in the animal kingdom explored in special issue of the Biological Bulletin
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... other chronic inflammatory disorders among people of lower socioeconomic ... exposure to the microbes that thrive in rural environments, ... published in the journal Clinical & Experimental Immunology ... have less access to green spaces may be more ... immune system dysfunction. , When our immune systems are ...
(Date:4/23/2014)... most in their mid-thirties and forties, face a ... within two decades. "Mutant" protein clusters, long blamed ... been the primary focus of therapies in development ... from Prof. Gerardo Lederkremer and Dr. Julia Leitman ... and Immunology, in collaboration with Prof. Ulrich Hartl ...
(Date:4/23/2014)... Valley, NY. (Apr. 23, 2014) People who have ... potential to restore neurological function. However, a study conducted ... issue of Cell Transplantation , but is currently ... http://www.ingentaconnect.com/content/cog/ct/pre-prints/content-ct1168Chen , has found that when one group ... cells (PBSCs) injected directly into the brain and a ...
Breaking Biology News(10 mins):Rural microbes could boost city dwellers' health 2Rural microbes could boost city dwellers' health 3On the defensive 2On the defensive 3Autologous stem cell therapy improves motor function in chronic stroke victims 2
... relocation of an Inuit village already underway, some 400 ... in Alaska for a UN-affiliated conference April 20-24 to ... to both mitigate and adapt to climate change. ... Global Summit on Climate Change is also designed to ...
... Biology 2009 meeting in New Orleans, Dr. Kristine ... Control Technologies Branch of the Health Effects Laboratory ... results from the first study to directly link ... with exposure to different vibration frequencies with biological ...
... grew warmer from 18,700 to 10,000 years ago, juniper trees ... of their favorite food. Now, University of Utah biologists have ... eat toxic creosote bushes that replaced juniper. "It was ... Dearing, senior author of the study, published online Tuesday, April ...
Cached Biology News:Indigenous peoples at world summit to share climate change observations, coping techniques 2Indigenous peoples at world summit to share climate change observations, coping techniques 3Indigenous peoples at world summit to share climate change observations, coping techniques 4Indigenous peoples at world summit to share climate change observations, coping techniques 5Indigenous peoples at world summit to share climate change observations, coping techniques 6Risk of vibration-induced vascular injuries linked to vibration frequency differences 2Poison: It's what's for dinner 2Poison: It's what's for dinner 3Poison: It's what's for dinner 4Poison: It's what's for dinner 5
(Date:1/15/2014)... (PRWEB) January 15, 2014 2013 was ... Scottsdale’s Brain State Technologies®. They saw continued independent research ... Center who were awarded a $1 million grant from ... in “Brain and Behavior” a peer reviewed journal, Amy ...
(Date:1/14/2014)... Doylestown, PA (PRWEB) January 14, 2014 Date: ... p.m. , Location: Warrington Country Club, 1360 Almshouse Road, Warrington, ... only national nonprofit organization solely dedicated to finding a cure ... those affected worldwide, will host its annual Crystal Ball on ...
(Date:1/14/2014)... As pet owners drew up their lists of New Year,s ... better care of my furry companion." Nowadays there are pet salons, ... cases to take the little canine or feline darlings along wherever ... buy some pricey toys at the pet store. But anyone who ...
(Date:1/14/2014)... iLab Solutions, the leader in core facility management ... Product Strategy. In this role, Michelle will work with current ... in the development of iLab products. Her main goal will ... to the scientific community by offering the most advanced, user-friendly, ...
Breaking Biology Technology:Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2
... - GeneNews Limited (TSX: GEN), a company focused on ... diseases and personalized health management, today announced that it ... being held at the Sheraton Centre in Toronto from ... booth # 400, will feature the Company,s lead product, ...
... and CAMBRIDGE, England, November 26 Sosei,Group Corporation ("Sosei"; ... it has out-licensed its IP and Know How,relating to ... a,Cambridge, UK based pharma company, for the treatment and ... Mefloquine is a highly efficacious anti-malarial drug that is ...
... CAS REGISTRY, the world,s most,authoritative collection of disclosed chemical ... CAS Registry Number(R),1073662-18-6 recently was assigned to an azulenobenzofuran ... http://www.newscom.com/cgi-bin/prnh/20081125/CLTU095 ) , ... The 40 millionth substance ...
Cached Biology Technology:GeneNews to exhibit ColonSentry(TM) at Family Medicine Forum 2008 2Sosei Announces the Out-licensing of RS(+) Mefloquine to Treague Ltd for the Treatment and Prophylaxis of Malaria 2CAS Registers 40 Millionth Substance in CAS REGISTRY(SM) 2
... HistoMark Biotin Streptavidin-HRP Systems provide ... and intracellular antigens in frozen or ... These systems also facilitate double ... can be performed simultaneously with primary ...
...
... Polystyrene covers can be used ... Ridged covers for stacking of ... covers for use with automated ... ridged and non-ridged, are available ...
... Versatile, modular, computer controlled pre-amplifier suitable for ... isolated electrode input for recording physiological signal ... and a transducer input for use with ... transducers. Additional options include a stimulus artefact ...
Biology Products: