Navigation Links
Toxoplasmosis: The strain explains severity of infection
Date:3/14/2011

Providing clues into why the severity of a common parasitic infection can vary greatly from person to person, a new Johns Hopkins study shows that each one of three strains of the cat-borne parasite Toxoplasma gondii sets off a unique reaction in the nerve cells it invades.

Past research suggests that the parasite, estimated to infect 25 percent of people worldwide, can trigger or exacerbate psychotic symptoms and schizophrenia in genetically predisposed people.

The findings of the new study, published in the March issue of the journal Infection and Immunity, help explain why the infection causes serious disease in some but not in others and clarify its role in psychiatric disorders, the researchers say.

"We already know that toxoplasmosis can play a role in some psychiatric disorders, but up until now we didn't know why. Working with human nerve cells, our study shows the exact alterations triggered by each strain that can eventually manifest themselves as symptoms," says senior investigator Robert Yolken, M.D., a neurovirologist at the Johns Hopkins Children's Center.

The researchers injected human nerve cells with the three most common toxoplasma strains, each of which caused a different pattern of gene expression. One of the most basic functions in all living organisms, gene expression occurs when a gene is switched on to release a substance that tells cells what to do or not do, determining the cells' biologic behavior. Gene expression can be turned on and off, stepped up or down by various factors, including viral and bacterial invasions.

Cells infected with toxoplasma type I -- the most virulent strain in mice -- had the greatest impact on gene expression, altering more than 1,000 genes, 28 of them linked to brain development and central nervous system function and 31 others to nerve impulse and signaling.

Cells injected with the less virulent types II and III had low and moderate levels
'/>"/>

Contact: Ekaterina Pesheva
epeshev1@jhmi.edu
410-516-4996
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related biology news :

1. Ben-Gurion U. and PTT Chemical sign R&D agreement to commercialize green algae strain
2. H1N1 pandemic points to vaccine strategy for multiple flu strains
3. Muscle filaments make mechanical strain visible
4. Cholera strain evolves new mechanism for causing disease
5. New way of predicting dominant seasonal flu strain
6. This faster-growing E. coli strains a good thing
7. New strain of high-runner rats uniquely resistant to disease -- all disease!
8. Mans closest relationship under strain? New research reveals why chimpanzees attack humans
9. Scripps research scientists determine structure of immune molecule that counteracts HIV strains
10. High-strain tendons repair less frequently
11. Unexpectedly high rate of multiple strains in fungal infection
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... easier when it is related to ability that we ... a new melody more easily than learning how to ... Center for the Neural Basis of Cognition (CNBC)a joint ... Universityhave discovered a fundamental constraint in the brain that ... story in the Aug. 28, 2014, issue of ...
(Date:8/27/2014)... DURHAM, N.C. -- When we want to listen carefully ... talking. The second thing we do is stop moving ... unwanted sounds generated by our own movements. , This ... deep in the brain. Indeed, indirect evidence has long ... somehow influences the auditory cortex, which gives rise to ...
(Date:8/27/2014)... giant, frightening beasts. But every creature is a baby ... containing fossils of 24 very young dinosaurs and one ... overseen by a caretaker, according to a new study ... Hedrick and Peter Dodson led the work, collaborating with ... the specimen is held. Hedrick is a doctoral student ...
Breaking Biology News(10 mins):Pitt and Carnegie Mellon engineers discover why learning can be difficult 2Pitt and Carnegie Mellon engineers discover why learning can be difficult 3Stop and listen: Study shows how movement affects hearing 2Stop and listen: Study shows how movement affects hearing 3Penn paleontologists describe a possible dinosaur nest and young 'babysitter' 2Penn paleontologists describe a possible dinosaur nest and young 'babysitter' 3
... 2012, the prices of corn and soybean meal for ... reduce their costs, pork producers are looking for alternative ... the University of Illinois have developed equations for calculating ... rendering industry. Professor of animal sciences Hans H. ...
... There, the pitch by company CEO John R. Lewandowski, who ... could save one million lives every year with just refrigerator ... on Fortune Magazine/CNN online. The team,s product, based ... a magnetic substance that malaria parasites release when digesting red ...
... USA Geosphere papers posted online 4 ... Swath Mapping), EarthScope, CHIRP (compressed high-intensity radar pulse), and ... understanding of the nature of Earth. New locations studied: ... nation monument, Mxico; and Andalshatten batholith, central Norway. ...
Cached Biology News:Calculating phosphorus and calcium concentrations in meat and bone meal for pig diets 2Hand-held device cheaply, quickly diagnosis malaria 2Hand-held device cheaply, quickly diagnosis malaria 3Geosphere features top geoscience technology, including LiDAR, EarthScope, CHIRP, ALSM, and IODP 2Geosphere features top geoscience technology, including LiDAR, EarthScope, CHIRP, ALSM, and IODP 3Geosphere features top geoscience technology, including LiDAR, EarthScope, CHIRP, ALSM, and IODP 4Geosphere features top geoscience technology, including LiDAR, EarthScope, CHIRP, ALSM, and IODP 5Geosphere features top geoscience technology, including LiDAR, EarthScope, CHIRP, ALSM, and IODP 6Geosphere features top geoscience technology, including LiDAR, EarthScope, CHIRP, ALSM, and IODP 7Geosphere features top geoscience technology, including LiDAR, EarthScope, CHIRP, ALSM, and IODP 8Geosphere features top geoscience technology, including LiDAR, EarthScope, CHIRP, ALSM, and IODP 9Geosphere features top geoscience technology, including LiDAR, EarthScope, CHIRP, ALSM, and IODP 10
(Date:8/27/2014)... , Aug. 27, 2014  A novel ... to help physicians better identify early-stage disease, when ... disability, according to a new study in The ... Diagnostics (NYSE: DGX ) and other ... 14-3-3eta protein outperformed conventional antibody-serum testing, including rheumatoid ...
(Date:8/27/2014)... 27, 2014 Guggenheim Securities, the investment banking ... the hiring of veteran equity analyst Charles "Tony" Butler ... Butler will focus on the biotech/biopharma sector. ... of experience and a broad network of relationships in ... Director and Head of Equities at Guggenheim Securities. "His ...
(Date:8/27/2014)... (PRWEB) August 27, 2014 Flagship Biosciences ... services to the pharmaceutical and medical device industries, ... The fast growing company has consolidated its histology ... and Boulder to Westminster, CO, just north of Denver. ... Lab, 7575 W. 103rd Ave., Suite 100, Westminster, CO ...
(Date:8/27/2014)... -- Research and Markets  has announced the addition ... Industry Report 2014" report to their offering. ... Industry Report 2014 is a professional and in-depth study ... mass spectrometer industry. The report provides a ... and industry chain structure. The isotope ratio mass spectrometer ...
Breaking Biology Technology:Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 2Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 3Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 4Guggenheim Securities Hires Analyst Charles "Tony" Butler to Expand Healthcare Coverage 2Flagship Biosciences Announces Relocation and Expansion 2Global Stable Isotope Ratio Mass Spectrometer Industry Report 2014 2
... Instrumental in Dickinson Mental Health Center,s Ability ... to Track ... Oct. 18 Netsmart Technologies, Inc.,a leading provider of ... today announced that Netsmart customer,Dickinson Mental Health Center ranked ...
... Elekta, a global leader in radiation,oncology and ... at the 49th Annual Meeting of The American ... reduce,treatment times and increase efficiency. The meeting will ... Los Angeles Convention Center (Los Angeles,California, USA). Elekta ...
... Mass., Oct. 18 Alseres,Pharmaceuticals, Inc. (Nasdaq: ... Frank Bobe,Executive Vice President and Chief Business ... at Windhover Information,s 2nd,Annual Therapeutic Area Partnerships ... will be presenting an overview on Alseres ...
Cached Biology Technology:Netsmart Technologies Customer in Pennsylvania Recognized for Achieving Data Benchmarking Milestones 2Elekta Announces New Cancer Care Solutions and Highlights Personalized Efficiency at ASTRO 2007 2Elekta Announces New Cancer Care Solutions and Highlights Personalized Efficiency at ASTRO 2007 3Elekta Announces New Cancer Care Solutions and Highlights Personalized Efficiency at ASTRO 2007 4Alseres Pharmaceuticals, Inc. to Present at Windhover's Therapeutic Area Partnerships Conference 2
...
...
22 x 50 mm; No. 1 thickness range: 0.13 to 0.17 mm, suitable for work in histology, cytology, urinalysis and microbiology, precleaned, store at room temperature ...
... 2.5%,Adenosine ... <0.1%,Cystathionine ... <0.1%,Glutathione ... 0.1 ug/ml to 1 mg/ml,(0.26 M to 2.6 mM) Sensitivity: around ...
Biology Products: