Navigation Links
Toxic bile damages the liver
Date:10/24/2008

Researchers at the Heidelberg University Hospital have discovered a new genetic disease that can lead to severe liver damage. Because a protective component of the bile is missing, the liver cells are exposed to the toxic components of the bile, resulting in cirrhosis of liver, a transformation of liver cells into connective tissue with a gradual loss of liver function. This could explain some of the cases of liver cirrhosis of unknown origin and open up a new approach for treatment. The research has now been published in the journal "Hepatology".

Some of the known frequent causes of cirrhosis of the liver are liver inflammation due to a virus, alcohol abuse, autoimmune disease, and metabolic defects. But in some 15 to 20 percent of patients, the cause is unknown and the appropriate treatment cannot be initiated.

Defective transporter protein makes the bile toxic

The Heidelberg University Hospital team, including Dr. Daniel Gotthardt and Dr. Peter Sauer of the Gastroenterology Department and Dr. Heiko Runz and Professor Dr. Johannes Zschocke of the Institute of Human Genetics, discovered that a mutation of the ABCB4 gene can cause inadequate secretion of bile in the liver, giving rise to cirrhosis. The illness can begin in childhood or at an adult age and lead to death. The gene ensures the production of a transporter protein that is responsible for the excretion of phosphatidylcholine into bile. Phosphatidylcholine protects the liver from toxic substances in the bile; a low concentration can thus lead to liver damage.

It was already known that another mutation in the ABCB4 gene can cause severe liver disease in babies. The disease occurs only if the gene is inherited from both father and mother. Women who carry the mutated ABCB4 gene but are not themselves affected have a clearly increased risk of suffering from pronounced jaundice during pregnancy. Genetic counseling and close supervision during pregnancy should be considered.


'/>"/>

Contact: Dr. Annette Tuffs
annette.tuffs@med.uni-heidelberg.de
49-622-156-4536
University Hospital Heidelberg
Source:Eurekalert

Related biology news :

1. How to build crops that can beat aluminums toxic effects
2. UC Riverside biochemists devise method for bypassing aluminum toxicity effects in plants
3. Are we trading energy conservation for toxic air emissions?
4. UI researchers find potentially toxic substance present in Chicago air
5. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
6. Scientists form alliance to develop nanotoxicology protocols
7. Biologists find diatom to reduce red tides toxicity
8. Landmark studies assess risk of exposure to elevated levels of EMS confirm clear toxicity threshold
9. Toxic chemicals found in common scented laundry products, air fresheners
10. New oral angiogenesis inhibitor offers potential nontoxic therapy for a wide range of cancers
11. Domoic acid from toxic algal blooms may cause seizures in California sea lions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/19/2017)... The global military biometrics market ... by the presence of several large global players. The ... major players - 3M Cogent, NEC Corporation, M2SYS Technology, ... 61% of the global military biometric market in 2016. ... military biometrics market boast global presence, which has catapulted ...
(Date:4/13/2017)... April 13, 2017 According to a new market ... Identity Analytics, Identity Administration, and Authorization), Service, Authentication Type, Deployment Mode, Vertical, ... Market is expected to grow from USD 14.30 Billion in 2017 to ... of 17.3%. ... MarketsandMarkets Logo ...
(Date:4/11/2017)... -- NXT-ID, Inc. (NASDAQ:   NXTD ) ("NXT-ID" ... of independent Directors Mr. Robin D. Richards and ... furthering the company,s corporate governance and expertise. ... Gino Pereira , Chief Executive Officer ... guidance and benefiting from their considerable expertise as we move ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... Proscia Inc ., a ... Webinar titled, “Pathology is going digital. Is your lab ready?” with Dr. Nicolas ... practices and how Proscia improves lab economics and realizes an increase in diagnostic ...
(Date:10/11/2017)... ... 11, 2017 , ... A new study published in Fertility ... fresh in vitro fertilization (IVF) transfer cycles. The multi-center matched cohort ... After comparing the results from the fresh and frozen transfer cohorts, the authors ...
(Date:10/10/2017)... PA (PRWEB) , ... October 10, 2017 , ... ... City Science Center’s FirstHand program has won a US2020 STEM Mentoring Award. Representatives ... the award for Excellence in Volunteer Experience from US2020. , US2020’s mission is ...
(Date:10/10/2017)... ... 10, 2017 , ... USDM Life Sciences , the ... sciences and healthcare industries, announces a presentation by Subbu Viswanathan and Jennifer Jaye ... GxP Validation for Agile Cloud Platforms,” will present a revolutionary approach to achieving ...
Breaking Biology Technology: