Navigation Links
Toward new medications for chronic brain diseases
Date:4/20/2011

A needle-in-the-haystack search through nearly 390,000 chemical compounds had led scientists to a substance that can sneak through the protective barrier surrounding the brain with effects promising for new drugs for Parkinson's and Huntington's disease. They report on the substance, which blocks formation of cholesterol in the brain, in the journal, ACS Chemical Biology.

Aleksey G. Kazantsev and colleagues previously discovered that blocking cholesterol formation in the brain could protect against some of the damage caused by chronic brain disorders like Parkinson's disease. Several other studies have suggested that too much cholesterol may kill brain cells in similar neurodegenerative diseases. So they launched a search for a so-called "small molecules" substances ideal for developing into medicines capable of blocking formation of cholesterol.

They describe discovery of a small molecule that blocks the activity of a key protein involved in cholesterol production. It successfully lowered cholesterol levels in isolated nerve cells and brain slices from mice. If the molecule proves to be a good target for developing new drugs, the scientists note, "it could have a broader application in other neurological conditions, such as Alzheimer's disease, for which modulation of cholesterol and other associated metabolic pathways might be of therapeutic benefit."


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

Page: 1

Related biology news :

1. Toward a more efficient use of solar energy
2. Toward a green grid for delivering solar and wind-based electricity
3. Progress toward the clinical application of autologous induced pluripotent stem cells and gene repair therapy for treatment of familial hypercholesterolemia
4. An advance toward blood transfusions that require no typing
5. Its time to take a unified approach toward measuring sustainability
6. Green chemistry offers route towards zero-waste production
7. Researchers working toward automating sedation in intensive care units
8. A nanoscale rope, and another step toward complex nanomaterials that assemble themselves
9. Toward controlling fungus that caused Irish potato famine
10. Big city life may make residents lean toward green, study says
11. Tracing microbes between individuals towards personalized oral health care
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... 22, 2014 Research and Markets ... addition of the "The Global Watermarking ... offering. http://photos.prnewswire.com/prnh/20130307/600769 ... overview of the global digital media watermarking ... and monitor piracy by securely and invisibly ...
(Date:12/19/2014)... 18, 2014   LaunchKey , the first decentralized ... and Internet of Things era, today announced the close ... round was led by Metamorphic Ventures with participation from ... VegasTechFund, and others.  LaunchKey has raised $4 million to ... its team and bring LaunchKey to market in 2015. ...
(Date:12/17/2014)... Dec. 16, 2014 Research and Markets ... of the "Global Chemical Sensor Market 2015-2019" ... http://photos.prnewswire.com/prnh/20130307/600769 One major ... demand for medical sensors in biomedical applications. Chemical ... quick and correct diagnosis during surgical procedures. The ...
Breaking Biology News(10 mins):The Global Watermarking and Fingerprinting Markets 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2
... will publish research that demonstrates how a biosensor can detect ... step in identifying and fighting superbugs, a major public health ... the United States in recent years. The technology is ... University and the Keesler Air Force Base with funding from ...
... Scientists have discovered that fat cells in the knee ... the way for new gene therapies that could offer relief ... in the knee joints secretes a protein called pro-factor D ... that is linked to arthritis," said Nirmal Banda, Ph.D., associate ...
... May 7, 2013 From New York City,s Central Park ... store an estimated 708 million tons of carbon, an environmental ... a recent U.S. Forest Service study. Annual net ... tons and $1.5 billion in economic benefit. In the ...
Cached Biology News:Biosensor that detects antibiotic resistance brings us one step closer to fighting superbugs 2Discovery shows fat triggers rheumatoid arthritis 2US urban trees store carbon, provide billions in economic value 2US urban trees store carbon, provide billions in economic value 3US urban trees store carbon, provide billions in economic value 4US urban trees store carbon, provide billions in economic value 5US urban trees store carbon, provide billions in economic value 6
(Date:12/24/2014)... Missouri (PRWEB) December 23, 2014 GMO ... Swiss biotechnology company, Syngenta, are in the process of ... proceedings. The consolidated case is In Re: Syngenta AG ... U.S. District Court for the District of Kansas. , ... has been handed over to U.S. District Judge John ...
(Date:12/24/2014)... December 23, 2014 ... is designed to introduce cutting edge communication ... and partners of platform upgrades. This webinar ... empowering users in their quest to leverage ... , According to SoundConnect’s Marketing Manager, Seanna ...
(Date:12/24/2014)... York (PRWEB) December 23, 2014 According to ... Long Island Affiliate of ITRA Global, the national office market ... steady recovery. This is evidenced by the third quarter’s ... stock market. Low energy costs have held inflation down ... only negative is the housing market remaining soft. , This ...
(Date:12/24/2014)... Nashville Fertility Center announced that ... the American Society for Reproductive Medicine (ASRM), a leading ... reproductive medicine. In his new role as treasurer, ... board and will have a voice in furthering the ... supported ASRM since 1984 when he joined while conducting ...
Breaking Biology Technology:Carey Danis & Lowe Reports on Syngenta GMO Corn Transfer Order 2SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3ITRA Global Reports Long Island Is Out of Sync With The National Office Market 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 3Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 3
... 2011 Tengion, Inc. (Nasdaq: TNGN ), a ... President and Chief Executive Officer of Tengion, will present at ... Monday, February 14, 2011, at 2:00 p.m. EST.  Dr. Nichtberger ... Open or Wide Open?" the following day on Tuesday, February ...
... MIAMI, Feb. 7, 2011 Based on U.S. Patent 7,824,612 ... Programming Same"), Fuisz Pharma today announced the use of their ... smart tablets that communicate with personal body fluid analyzers. ... acceptable analyte values for body fluids, set by the drug ...
... JEFFERSON CITY, Mo., Feb. 4, 2011 The ... the most prestigious biofuels scientists in the world.  This year, ... to bring about 10 college students to the event, Feb. ... http://photos.prnewswire.com/prnh/20100830/DC56543LOGO-b ) Evan Le, a senior studying mechanical ...
Cached Biology Technology:Tengion to Present at the 13th Annual BIO CEO & Investor Conference and the Leerink Swann 'Hot Topics in Therapeutics' Roundtable Conference 2National Biodiesel Conference Invests in 'Next Generation' Scientists 2
... of a series of media originally developed at ... al. for the large scale propagation of cells ... primarily used for the growth and maintenance of ... of viruses in these cell lines. One of ...
... Trx•Tag™ Ek Adaptor encodes a T7 promoter, ... (rbs), ATG translation initation codon, and an ... a 109 aa sequence that encodes thioredoxin. ... to enhance solubility of many proteins that ...
... This CLS number is ... to easily match Cornings product ... yet, please order under the ... contact customer service for assistance. ...
A cost-effective serum for general cell growth requirements. All serum is collected from calves aged 10 days old or less....
Biology Products: