Navigation Links
Toward new medications for chronic brain diseases
Date:4/20/2011

A needle-in-the-haystack search through nearly 390,000 chemical compounds had led scientists to a substance that can sneak through the protective barrier surrounding the brain with effects promising for new drugs for Parkinson's and Huntington's disease. They report on the substance, which blocks formation of cholesterol in the brain, in the journal, ACS Chemical Biology.

Aleksey G. Kazantsev and colleagues previously discovered that blocking cholesterol formation in the brain could protect against some of the damage caused by chronic brain disorders like Parkinson's disease. Several other studies have suggested that too much cholesterol may kill brain cells in similar neurodegenerative diseases. So they launched a search for a so-called "small molecules" substances ideal for developing into medicines capable of blocking formation of cholesterol.

They describe discovery of a small molecule that blocks the activity of a key protein involved in cholesterol production. It successfully lowered cholesterol levels in isolated nerve cells and brain slices from mice. If the molecule proves to be a good target for developing new drugs, the scientists note, "it could have a broader application in other neurological conditions, such as Alzheimer's disease, for which modulation of cholesterol and other associated metabolic pathways might be of therapeutic benefit."


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

Page: 1

Related biology news :

1. Toward a more efficient use of solar energy
2. Toward a green grid for delivering solar and wind-based electricity
3. Progress toward the clinical application of autologous induced pluripotent stem cells and gene repair therapy for treatment of familial hypercholesterolemia
4. An advance toward blood transfusions that require no typing
5. Its time to take a unified approach toward measuring sustainability
6. Green chemistry offers route towards zero-waste production
7. Researchers working toward automating sedation in intensive care units
8. A nanoscale rope, and another step toward complex nanomaterials that assemble themselves
9. Toward controlling fungus that caused Irish potato famine
10. Big city life may make residents lean toward green, study says
11. Tracing microbes between individuals towards personalized oral health care
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/16/2016)... MIAMI , Dec. 16, 2016   ... intuitive Identity management products and solutions and a ... announced today that it is offering seamless, integrated ... Edam security entrance products. The solutions provide IdentyTech,s ... to secure their facilities from crime and theft. ...
(Date:12/15/2016)... VANCOUVER, Canada and BADEN-BADEN, Germany ... Solutions, a leading global financial services provider, today announced an ... in passive behavioural biometrics, to join forces. The partnership will ... fraud mitigation strategies in compliance with local data protection regulation. ... In ...
(Date:12/15/2016)... , Dec. 15, 2016 ... driving experience, health wellness and wellbeing (HWW), ... one in three new passenger vehicles begin ... recognition, gesture recognition, heart beat monitoring, brain ... monitoring, facial monitoring, and pulse detection. These ...
Breaking Biology News(10 mins):
(Date:1/24/2017)... ... January 24, 2017 , ... ZeptoMetrix ... falciparum culture panels with standard concentrations of histidine rich protein 2 (HRP2). ... range of concentrations from six different malaria strains, are intended for use by ...
(Date:1/24/2017)... ... January 23, 2017 , ... Oklahoma City based Sigma ... client for the firm’s PERFEQTA software and legacy product QC Manager 2.0. , ... dynamic team at CJBC and thrilled that they have decided to implement PERFEQTA and ...
(Date:1/24/2017)... Jan. 23, 2017 /PRNewswire/ - BioAmber Inc. (NYSE: ... an underwriting agreement with Rodman & Renshaw, a unit ... sole book running manager and representative of several underwriters, under ... firm commitment basis a minimum of 2,105,264 shares of ... purchase a minimum of 1,052,632 shares of common stock ...
(Date:1/23/2017)... Atlas Genetics Ltd., the ultra-rapid Point-Of-Care (POC) molecular ... raising $35 million from a syndicate including all Series C ... ... Genetics io® system has been completed with the successful CE ... 2016.  This new Series D equity issue will finance the ...
Breaking Biology Technology: