Navigation Links
Toward a safer form of acetaminophen
Date:7/10/2013

Efforts to develop a safer form of acetaminophen the pain and fever-reducer that is one of the most widely used drugs have led to discovery of substances that may have less potentially toxic effects on the liver. A report on the research appears in ACS Medicinal Chemistry Letters.

Roman Shchepin and colleagues explain that a link exists between acetaminophen and liver damage. The damage may be severe and can occur with intentional and accidental overdoses, as well as when susceptible individuals take the drug. Indeed, acetaminophen has been implicated in almost 50 percent of all acute liver failure cases in the United States alone. Scientists have known the biochemical basis of acetaminophen's liver toxicity, and Shchepin and colleagues set out to develop safer versions of acetaminophen.

They describe the design and testing of two compounds that have a similar architecture to acetaminophen, but aren't toxic to liver cells grown in the laboratory. The researchers say that, although further testing is needed, these compounds are promising candidates for acetaminophen replacements.


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

Page: 1

Related biology news :

1. New materials, progress toward an HIV vaccine, and more at meeting of crystallographers
2. UCLA stem cell gene therapy for sickle cell disease advances toward clinical trials
3. Toward broad-spectrum antiviral drugs for common cold and other infections
4. NREL drives toward the future with fuel cell EVs
5. Engineered stem cell advance points toward treatment for ALS
6. A giant step toward miniaturization
7. The large-scale EU project EU BON: Towards integration with its global counterpart GEO BON
8. Towards more sustainable construction
9. Report: Water and Agriculture in Canada: Towards Sustainable Management of Water Resources
10. Fat worms inch scientists toward better biofuel production
11. BESAFE Conference in Manchester: Working towards a brighter future for biodiversity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... division of the striatum is also involved in ... of substance P in the striatal marginal division ... his team, College of Biophotonics, South China Normal ... P receptor, neurokinin 1 was highly expressed in ... rats. Unilateral or bilateral injection of an antisense ...
(Date:7/11/2014)... 2014 Research and Markets has ... Market - Industry Analysis Size Share Growth Trends and ... http://photos.prnewswire.com/prnh/20130307/600769 The ... a need for high level security in both private ... such as username and passwords, tokens etc. are vulnerable ...
(Date:7/10/2014)... other major cities in New Mexico, nearly every public ... rather than precious potable water supplies. Across the U.S. ... golf courses receive treated effluent. Reusing the effluent increases ... courses and homeowners alike fertilize their lawns during the ... A New Mexico State University turfgrass expert has a ...
Breaking Biology News(10 mins):International Biometrics Technology Market - Industry Analysis Size Share Growth Trends and Forecast to 2019 2'Tailored' water -- the latest in lawn care 2
... Researchers at the Burnham Institute for Medical Research (Burnham) ... a disorder called Sporadic Inclusion Body Myositis (sIBM). sIBM ... causing muscles to gradually weaken and waste away. The ... it is the most common muscle disease among those ...
... in a forthcoming issue of the International Journal of ... with a synthetic bone material prior to implantation allows ... the jaw, leading to smiles all round. Titanium ... medical implants. However pure titanium has a biologically inert ...
... Margaret Munro and Dr. Richard Smith have won the American ... will receive the David Perlman Award for Excellence in Science ... Canada in 30 years of an ice shelf suspected ... appeared in The Gazette, the largest English-language daily newspaper in ...
Cached Biology News:RING finger protein 5 may guide treatment for muscle disease in older adults 2RING finger protein 5 may guide treatment for muscle disease in older adults 3Crowning glory 2AGU Journalism Awards won by Margaret Munro and Dr. Richard Smith 2
(Date:7/10/2014)... upside down forever. Nanophysics makes sure of that. Mechanics researchers ... published in Physical Review E . Knowledge that can ... seem to be able to sit still forever, and walk ... We will soon be able to buy smart new fasteners ... the fact is, sooner or later the grip is lost, ...
(Date:7/10/2014)... researchers at the University of Illinois at Urbana-Champaign ... the interplay of spin and heat at the ... spintronic devices for data storage and information processing. ... as spin-angular momentum. In a typical charge current, ... spin current," explained David Cahill, a professor of ...
(Date:1/15/2014)... akin to assembling a club sandwich at the ... researchers have succeeded in crafting a uniform, multi-walled ... foam commonly used in upholstered furniture and other ... polyurethane foam was reduced 35 percent compared with ...
(Date:1/15/2014)... Automotive, a group of car dealerships headquartered in ... Center and offering free oil change coupons for participation in ... 18 at the Bill Jacobs Cadillac and Chevrolet location from ... )  The Bill Jacobs Auto annual blood ...
Breaking Biology Technology:Even geckos can lose their grip 2University of Illinois study advances limits for ultrafast nano-devices 2Layered security: Carbon nanotubes promise improved flame-resistant coating 2Join the Bill Jacobs Auto blood drive and receive a free oil change 2
... , Editors say the ... to changing nature of biological research , BETHESDA, Md. , ... are unveiling this week a number of changes to the journal,s ... increasingly interdisciplinary nature of biological research and will help the journal ...
... , DENVER, CO , Jan. 14 ... MIT is pleased to announce that it has received ... , MIT,s shares will be posted for trading on ... 14, 2010 , under the ticker symbol MDLH.OB. , This is ...
... , , STOCKHOLM , ... today the formation of BioChromix Pharma AB, a,new company working to ... Karolinska Development will initially take,28 percent ownership in the new company. ... Pharma as they have a novel,approach that targets the cause of ...
Cached Biology Technology:Journal of Biological Chemistry Changes Approach to Manuscript Reviews and Eliminates Submission Fees 2Journal of Biological Chemistry Changes Approach to Manuscript Reviews and Eliminates Submission Fees 3MIT is pleased to announce that it has received clearance by FINRA to be listed on the OTC Bulletin Board "MDLH.OB" 2Karolinska Development Expands its Life Science Portfolio With BioChromix Pharma 2Karolinska Development Expands its Life Science Portfolio With BioChromix Pharma 3
Because it is manufactured at our ISO 9001–certified facilities in Eugene, Oregon, we can guarantee that FluoroPure grade propidium iodide is greater than or equal to 98% pure by HPLC....
MOUSE ANTI RAT RT1Bu Immunogen: Rat thymocyte membrane glycoproteins...
... (100+kb), fosmid (40kb), and large plasmid insert ... othe BAC vector. On command 20-50 fold ... recombinant DNA purification. Available with blue-white screening ... for the highest insert stability. Kits include ...
SHEEP ANTI HUMAN ESTRONE...
Biology Products: