Navigation Links
Tortoise and the hare: New drug stops rushing cancer cells, slow and steady healthy cells unharmed
Date:3/2/2012

The American Cancer Society estimates that 44,000 new cases of pancreatic cancer will be diagnosed this year and that 37,000 people will die from the disease. These are not strong odds. A new drug, rigosertib, allows pancreatic cancer cells to rush through replication and then stops them cold, killing them in in the middle of a step called M phase. Healthy cells that don't rush are unharmed.

Data from a phase I clinical trial of patients with advanced pancreatic cancer and additional solid tumors recently published in the journal Clinical Cancer Research shows the strategy has promise. While the goal of any phase I trial is to establish the dosage that best balances effectiveness against side effects, 11 of the 19 patients treated achieved stable disease, which lasted for a median of 113 days.

"Really, the drug takes one of cancer's greatest strengths and turns it into a weakness," says Wells Messersmith, MD, co-leader of the Developmental Therapeutics Program at the University of Colorado Cancer Center and the clinical trial's national principal investigator.

Instead of going with the flow of the natural cell cycle, cancer cells amplify two signals PLK1 and PI3K which allows them to blast through the cell cycle and divide much more quickly. In the process, they break this step of the natural cell cycle, known as the G1 regulatory mechanism, and thus depend on the kick of PLK1 and P13K to push at a frenzied pace through replication.

It's specifically these two signals, PLK1 and PI3K, that rigosertib targets. With these signals turned off, cancer cells get stuck and die in the stage of the cell cycle called M phase while healthy cells that stuck to the slower, natural method of division chug past unharmed.

Wells Messersmith, MD, co-leader of the Developmental Therapeutics Program at the University of Colorado Cancer Center

"This one-two punch, targeting these two distinct signaling pathways, allows us to interfere twice with cancer cells' ability to replicate," Messersmith says. And it also allows doctors to target cancers that may have evolved resistance to one or the other target.


'/>"/>

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

Related biology news :

1. Extinct for 150 years, an iconic Galpagos giant tortoise species lives
2. Tortoise populations can withstand fires every 30 years
3. Giant tortoises show rewilding can work
4. In the race of life, better an adaptable tortoise than a fit hare
5. New study shows how giant tortoises, alligators thrived in High Arctic 50 million years ago
6. Madagascars radiated tortoise threatened with extinction
7. New theory shows that neither birth nor death stops a flock
8. Path to oxygen in Earths atmosphere: long series of starts and stops
9. Athletic girls more likely to have impaired bone structure if menstrual cycle stops
10. Policing stops cheaters from dominating groups of cooperative bacteria
11. Researchers find drug that stops progression of Parkinsons disease in mice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2017)... 2017 UBM,s Advanced Design and Manufacturing event ... emerging and evolving technology through its 3D Printing and ... alongside the expo portion of the event and feature ... focused on trending topics within 3D printing and smart ... event will take place June 13-15, 2017 at the Jacob ...
(Date:4/11/2017)... NXT-ID, Inc. (NASDAQ:   NXTD ) ("NXT-ID" or ... independent Directors Mr. Robin D. Richards and Mr. ... the company,s corporate governance and expertise. ... Gino Pereira , Chief Executive Officer said," ... and benefiting from their considerable expertise as we move forward ...
(Date:4/4/2017)... 4, 2017   EyeLock LLC , a leader ... United States Patent and Trademark Office (USPTO) has issued ... linking of an iris image with a face image ... the company,s 45 th issued patent. ... timely given the multi-modal biometric capabilities that have recently ...
Breaking Biology News(10 mins):
(Date:9/21/2017)... ... September 21, 2017 , ... Executives ... the world’s most progressive pharma and biotech organizations to do more clinical trials ... and biotech events in Q4. , DrugDev will demonstrate DrugDev Spark™, the world’s ...
(Date:9/21/2017)... SAN DIEGO, CALIF. (PRWEB) , ... September 21, 2017 , ... ... kitchen earlier this month. The organization, a worldwide society of professional women with ... a venue to hold its annual dinner. , Twelve members began with ...
(Date:9/20/2017)... ... September 20, 2017 , ... Cybrexa Therapeutics , a ... the role of chief scientific officer. In this role, Dr. Paralkar will lead ... and CEO, Per Hellsund. , “I was impressed with Cybrexa’s revolutionary technology and ...
(Date:9/20/2017)... ... September 20, 2017 , ... Proscia ... Pathology , a provider of whole slide imaging solutions, are hosting a pre-conference ... workshop, entitled “Successfully Deploying a Best-in-Class Strategy for Digital Pathology,” will feature Proscia ...
Breaking Biology Technology: