Navigation Links
Tortoise and the hare: New drug stops rushing cancer cells, slow and steady healthy cells unharmed
Date:3/2/2012

The American Cancer Society estimates that 44,000 new cases of pancreatic cancer will be diagnosed this year and that 37,000 people will die from the disease. These are not strong odds. A new drug, rigosertib, allows pancreatic cancer cells to rush through replication and then stops them cold, killing them in in the middle of a step called M phase. Healthy cells that don't rush are unharmed.

Data from a phase I clinical trial of patients with advanced pancreatic cancer and additional solid tumors recently published in the journal Clinical Cancer Research shows the strategy has promise. While the goal of any phase I trial is to establish the dosage that best balances effectiveness against side effects, 11 of the 19 patients treated achieved stable disease, which lasted for a median of 113 days.

"Really, the drug takes one of cancer's greatest strengths and turns it into a weakness," says Wells Messersmith, MD, co-leader of the Developmental Therapeutics Program at the University of Colorado Cancer Center and the clinical trial's national principal investigator.

Instead of going with the flow of the natural cell cycle, cancer cells amplify two signals PLK1 and PI3K which allows them to blast through the cell cycle and divide much more quickly. In the process, they break this step of the natural cell cycle, known as the G1 regulatory mechanism, and thus depend on the kick of PLK1 and P13K to push at a frenzied pace through replication.

It's specifically these two signals, PLK1 and PI3K, that rigosertib targets. With these signals turned off, cancer cells get stuck and die in the stage of the cell cycle called M phase while healthy cells that stuck to the slower, natural method of division chug past unharmed.

Wells Messersmith, MD, co-leader of the Developmental Therapeutics Program at the University of Colorado Cancer Center

"This one-two punch, targeting these two distinct signaling pathways, allows
'/>"/>

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

Page: 1 2

Related biology news :

1. Extinct for 150 years, an iconic Galpagos giant tortoise species lives
2. Tortoise populations can withstand fires every 30 years
3. Giant tortoises show rewilding can work
4. In the race of life, better an adaptable tortoise than a fit hare
5. New study shows how giant tortoises, alligators thrived in High Arctic 50 million years ago
6. Madagascars radiated tortoise threatened with extinction
7. New theory shows that neither birth nor death stops a flock
8. Path to oxygen in Earths atmosphere: long series of starts and stops
9. Athletic girls more likely to have impaired bone structure if menstrual cycle stops
10. Policing stops cheaters from dominating groups of cooperative bacteria
11. Researchers find drug that stops progression of Parkinsons disease in mice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/16/2015)... , March 16, 2015 ... Systems GmbH will present groundbreaking innovations in biometric ... Hanover, Germany .      (Photo: ... latest biometric innovation is well at the forefront: ... generation e-gate made in Germany ...
(Date:3/11/2015)... 11, 2015 Research and Markets ( ... "Access Control Market by Product, Application & By Geography ... to their offering. , This report predicts ... $10.4 billion by 2020, with an estimated CAGR of ... the products types such as contact cards & readers, ...
(Date:3/10/2015)... March 10, 2015  NXT-ID, Inc. (NASDAQ: ... "Company"), a biometric authentication company focused on the ... smart wallet has been named the "Number One ... Rethink Modern ( http://www.rethinkmodern.com/ ) is ... your home and lifestyle that have a unique function ...
Breaking Biology News(10 mins):DERMALOG Presents its Latest Biometric Innovations at the Hannover CeBIT Exhibition, 16 - 20 March 2015 2DERMALOG Presents its Latest Biometric Innovations at the Hannover CeBIT Exhibition, 16 - 20 March 2015 3Global Access Control (Cards & Readers, Biometrics, Controllers, Management Software) Market 2015-2020 - Analysis of the $10 Billion Market 2NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 2NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 3NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 4
... in hot and dry climates could make passengers more comfortable ... according to a study published in the International Journal ... Department of Mechanical Engineering, at the Indian Institute of Technology ... passenger trips are taken in open window buses. Worldwide, ...
... continues to puzzle scientists, long after the 200 years ... consistent patterns of biodiversity have been identified over space, ... of the process of "speciation" -- the evolutionary process ... theory. The first requires a physical barrier such as ...
... ice formation occurred in the Arctic earlier than previously ... week in Nature . "The results are also ... in the Arctic before it did in Antarctica, which ... Richard Pearce of the University of Southampton,s School of ...
Cached Biology News:Slotted buses keep passengers cool 2A global model for the origin of species independent of geographical isolation 2Early initiation of Arctic sea-ice formation 2Early initiation of Arctic sea-ice formation 3
(Date:3/30/2015)... 29, 2015 A two-day workshop on ... and plenary talks by four leading photonics researchers are ... Optoelectronics next month in Prague, Czech Republic. The ... conferences alongside a two-day exhibition. Sponsored by SPIE, ... event will run 13-16 April in the Clarion Congress ...
(Date:3/29/2015)... 2015  Caris Life Sciences® today announced the ... Intelligence®, the company,s panomic, comprehensive tumor profiling service, ... rare and difficult to treat gynecological cancers may ... to improve patient outcomes. These studies were presented ... of Gynecologic Oncology (SGO) 2015 Annual Meeting on ...
(Date:3/27/2015)... The consumption of compound fertilizers (NPK) fertilizers declined ... prices in 2008. However, the situation has stabilised afterwards, ... momentum now. , To date, the world annual production ... tonnes. No considerable growth was registered in the market ... 2012-2013, registering 11% growth as against the period of ...
(Date:3/27/2015)... , March 27, 2015 Working ... Free Hospital in London , Richmond Pharmacology ... a global Phase 3 study for an investigational RNAi therapeutic ... orphan disease affecting the nerves and heart. ... Detail Based at St Georges University of ...
Breaking Biology Technology:Laser Energy Advances Among Reports Set for SPIE Optics + Optoelectronics 2Laser Energy Advances Among Reports Set for SPIE Optics + Optoelectronics 3Caris Molecular Intelligence Facilitates Comparison of Biomarker Profiles to Inform Targeted Treatment Strategies in Distinct Gynecological Cancers 2Caris Molecular Intelligence Facilitates Comparison of Biomarker Profiles to Inform Targeted Treatment Strategies in Distinct Gynecological Cancers 3Caris Molecular Intelligence Facilitates Comparison of Biomarker Profiles to Inform Targeted Treatment Strategies in Distinct Gynecological Cancers 4World NPK Fertilizers Market Keeps On Gaining Momentum, According to BAC Reports Study Available at MarketPublishers.com 2World NPK Fertilizers Market Keeps On Gaining Momentum, According to BAC Reports Study Available at MarketPublishers.com 3
... , , , , ... a billionfold. Thus, even minuscule amounts of a contaminant ... false positive result. Such contaminants are often products , ... researchers have developed methods to avoid such contamination. , ...
... , , , , , For isolating genomic nucleic , ... , , , ... , 1796828, 1 kit ... , , , Special Interest Sites, , ...
... , , , , , ... 1691104, Set, , ... Instructions , , English , version - 24 ... , US Material Safety , Data Sheets , , ...
Cached Biology Technology:Preventing Carry-over Contamination with Uracil-DNA Glycosylase 2
Liquid. 50 μg/ml in PBS, pH 7.4. PROTECT FROM LIGHT. A convenient form of propidium iodide useful for flow cytometry studies. RTECS SF7949600, CAS 25535-16-4, M.W. 668.4. ...
... The MyCycler thermal cycler system is used ... This system includes the MyCycler personal thermal ... for use with 0.2 ml tubes or ... and both algorithm and block modes of ...
... been developed for affinity capture of ... of ProteinChip chemical surfaces allow differential ... unique biochemical properties. Each chip has ... comparison, and the chips are color-coded ...
The Freeze 'N Squeeze DNA gel extraction kit uses a quick freeze-and-thaw cycle and centrifugation to draw 50-23,000 bp DNA out of agarose gel slices. The kit includes materials for 100 preps....
Biology Products: