Navigation Links
Toronto team ID proteins key in stem cell production
Date:7/5/2013

TORONTO - A team of Toronto-based researchers may be one step closer to a 'recipe' for large-scale production of stem cells for use in research and therapy.

Induced pluripotent stem cells (iPSCs) can be of great value for medical research because they can flexibly develop into many different types of cells. However, producing these cells is challenging because the proteins that control their generation are largely unknown.

But researchers from the University of Toronto, the Hospital for Sick Children and Mount Sinai Hospital (with colleagues from the United States and Portugal) say they have identified certain proteins that play a key role in controlling pluripotency, which may mean a potential breakthrough in producing these cells.

The findings were recently published in Nature. One of the authors is University of Toronto Engineering professor Brendan Frey. He said the researchers discovered the proteins using the splicing code developed a few years ago by a team led by he and U of T Donnelly Centre researcher Benjamin Blencowe. "The mechanisms that control embryonic stem cell pluripotency have remained a mystery for some time. However, what Dr. Blencowe and the research team found is that the proteins identified by our splicing code can activate or deactivate stem cell pluripotency," Frey said.

When asked why the identification of these proteins is important, Frey gave the following analogy: "Suppose you've tasted many wonderful gourmet dishes, but you have absolutely no idea what's needed to make them. Then, one day, you discover that there's something called a 'measuring cup' that is used by all of the gourmet chefs. Now you understand something important about how dishes are prepared, and you also know about a 'control knob' that can be turned in order to make different dishes, just as adjusting the amount of butter and flour will give a different kind of pastry."

And while a complete recipe for producing iPSCs may not be available yet, Frey said, it's beginning to look more likely.


'/>"/>

Contact: Terry Lavender
terry.lavender@utoronto.ca
416-978-4498
University of Toronto Faculty of Applied Science & Engineering
Source:Eurekalert

Related biology news :

1. University of Toronto breakthrough allows fast, reliable pathogen identification
2. 7th Annual Canadian Neuroscience Meeting, Toronto, May 20-24, 2013
3. Saint Louis University, University of Toronto biologists help decode turtle genome
4. Predicting a low carbon future for Toronto
5. University of Toronto study demonstrates impact of adversity on early life development
6. University of Toronto wins third place at the Gates Foundations Reinvent the Toilet Challenge
7. University of Toronto biologists predict extinction for organisms with poor quality genes
8. Low levels of toxic proteins linked to brain diseases, study suggests
9. National Institutes of Health to fund research probing proteins linked to cancer, diabetes
10. Saliva proteins may protect older people from influenza
11. KISS ME DEADLY proteins may help improve crop yields
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/2/2016)... MOUNTAIN VIEW, Calif. , Feb. 2, 2016 ... diabetic retinopathy market, Frost & Sullivan recognizes US-based ... North America Frost & Sullivan Award for New ... technology provider in North America ... standard in the rapidly growing diabetic retinopathy market. ...
(Date:1/27/2016)... 2016  Rite Track, Inc. a leading semiconductor equipment ... Chester, Ohio announced today the acquisition of PLUS ... in Austin, Texas , will significantly ... modifications, installations and technical support offerings for TEL Track ... commented, "PLUS has provided world class service including refurbishment, ...
(Date:1/21/2016)... India , January 21, 2016 ... According to a new market research report "Emotion Detection ... and Others), Software Tools (Facial Expression, Voice Recognition ... Regions - Global forecast to 2020", published by ... is expected to reach USD 22.65 Billion by ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... SANTA CRUZ, Calif. , Feb. 11, 2016 /PRNewswire/ ... accepting applications to its beta program for a planned ... co-founder, will present the company,s metagenomic genome assembly method ... 2016 Advances in Genome Biology & Technology conference in ... novo  assembly of these highly complex datasets is difficult. ...
(Date:2/11/2016)... , Feb. 11, 2016   BioInformant ... report, "Stem Cell Research Products, Opportunities, Tools, and Technologies ... ... in the stem cell industry, BioInformant has more than ... the stem cell market, by stem cell type. This ...
(Date:2/11/2016)... , ... February 11, 2016 , ... ... medicine, has announced a new agreement with Bankok,Thailand-based Global Stem Cells Network (GSCN) ... phsyicians in 15 Latin American countries, including Mexico, Costa Rica, Dominican Republic, Colombia, ...
(Date:2/10/2016)... MONTREAL , Febr. 10, 2016 /PRNewswire/ - BioAmber Inc. ... is pleased to announce that Mitsui & Co. Ltd., ... bio-based succinic acid plant, is investing an additional CDN$25 ... equity, increasing its stake from 30% to 40%.  Mitsui ... of bio-succinic acid produced in Sarnia ...
Breaking Biology Technology: