Navigation Links
Toronto researchers first to discover new genetic clue in the development of rheumatoid arthritis
Date:8/14/2011

(August 14, 2011Toronto, ON) Scientists at Mount Sinai Hospital, in collaboration with researchers at the University of Toronto, University Health Network and McGill University have obtained significant new insights into the causes of rheumatoid arthritis (RA) and other autoimmune disorders including type 1 diabetes, lupus and Graves disease.

The findings represent a key initial step in realizing the full potential of genomics and personalized medicine.

In a study published online today in Nature Genetics, Dr. Katherine Siminovitch and her team identified the exact means by which an alteration in the gene PTPN22 increases risk for RA and other autoimmune disorders. The study used advanced genomics technologies that enable testing of millions of genetic markers in a single experiment to identify genes, such as PTPN22, that confer risk for disease.

The team then generated a mouse genetic model to show how the PTPN22 gene mutation impairs immune cell function and then validating their findings in humans, taking their discovery from the laboratory bench to the clinic.

The result: a more accurate understanding of how autoimmune conditions develop, and how new diagnostic tests and targeted therapies can be designed for better symptom control and potential cure.

"Our findings are particularly exciting because this study sets a new precedent for studying arthritis and other autoimmune disorders," said lead author Dr. Siminovitch, Senior Investigator and the Sherman Family Research Chair in Genomic Medicine at the Samuel Lunenfeld Research Institute of Mount Sinai Hospital, a professor at the University of Toronto, and Director of the Fred A. Litwin & Family Centre in Genetic Medicine.

"This is one of the first studies in which we have traced the steps that connect a specific genetic lesion to the development of a common, complex autoimmune condition."

Led by Dr. Siminovitch, the group used genet
'/>"/>

Contact: Karin Fleming
fleming@lunenfeld.ca
Samuel Lunenfeld Research Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. York U researcher finds new bee in downtown Toronto
2. Research network based at University of Toronto gets $5 million boost to speed up cancer detection
3. University of Toronto study shows disparity of effect of climate change on UV radiation
4. University of Toronto helps to barcode the worlds plants
5. Researchers decode workings of mysterious, but critical TB drug
6. Researchers fight cholera with computer forecasting
7. Vanderbilt researchers, international team, uncover genes linked to multiple sclerosis
8. Narcissism may benefit the young, researchers report; but older adults? Not so much
9. York U researchers zero in on protein that may help treat obesity, diabetes
10. Researchers use human cells to engineer functional anal sphincters in lab
11. Researchers use neutrons to spy on the elusive hydronium ion
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... 2 million Food Standards Agency (FSA) project to map ... workers. , Norovirus outbreaks can rapidly affect large ... frozen strawberries infected 11,000 people in Germany, but there ... strains cause infection and which foods are the most ... will produce data that will help the FSA to ...
(Date:4/22/2014)... Yale researchers will lead a five-year, $3 million study ... is affecting the transport of dissolved organic matter (DOM) ... could alter the chemical composition and water quality of ... from the National Science Foundation,s MacroSystems Biology program, researchers ... watershed, which begins in Canada and runs through five ...
(Date:4/22/2014)... RIVERSIDE, Calif. Inspired by the fist-like club ... by University of California, Riverside, in collaboration with University ... design structure for composite materials that is more impact ... , "The more we study the club of this ... improve so many things we use every day," said ...
Breaking Biology News(10 mins):Connecticut River watershed study will assess impacts of extreme rain events 2Connecticut River watershed study will assess impacts of extreme rain events 3Mantis shrimp stronger than airplanes 2Mantis shrimp stronger than airplanes 3
... University scientists have defined a hidden second option plants ... be the first step in boosting plants, nutritional value ... phenylalanine is required to build proteins and is a ... plants, including lignin, which allows plants to stand upright ...
... negative emotions they often use spatial metaphors. A happy person is ... in the dumps. Some researchers believe these metaphors are a clue ... spatial words to talk about emotional states, we also use spatial ... To test this link between vertical space and emotion, in ...
... Human Frontier Science Program Organization (HFSPO) is pleased to ... postdoctoral fellowships, career development awards and research grants. HFSP ... selection in a global competition. The names are available ... HFSP postdoctoral fellowships are given to young scientists ...
Cached Biology News:Second plant pathway could improve nutrition, biofuel production 2To remember the good times, reach for the sky 22010 Human Frontier Science Program awards announced 2
(Date:1/15/2014)... Rochester, NY (PRWEB) January 15, 2014 The ... cause a major disease. One of these latent viruses is ... is rheumatoid arthritis (RA). Rheumatoid arthritis (RA) is a chronic ... the theory, a study found that RA patients have high ...
(Date:1/15/2014)... 2014 2013 was a banner year ... Technologies®. They saw continued independent research led by the ... awarded a $1 million grant from the Susanne Marcus ... Behavior” a peer reviewed journal, Amy Grant highlighted Brainwave ...
(Date:1/15/2014)... AudioNotch is the internet's leading provider ... treatment of tinnitus. Patients listen to sound therapy that ... period of weeks to months, their tinnitus volume decreases. , ... Notched Music and Notched White Noise. Now, AudioNotch is pleased ...
(Date:1/14/2014)... Date: Friday, April 11, 2014 , Time: ... 1360 Almshouse Road, Warrington, Pa. , Details: The ... to finding a cure for hepatitis B and improving the ... annual Crystal Ball on Friday, April 11 at Warrington Country ...
Breaking Biology Technology:Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2
... Feb. 15, 2012 The Alfred P. Sloan Foundation ... U.S. and Canadian researchers as recipients of Sloan Research ... are given to early-career scientists and scholars whose achievements ... generation of scientific leaders. "Today,s Sloan Research ...
... German . , Back in 1920 at ... macromolecules consisting of many identical modules strung together like a ... from his fellow chemists. But Staudinger was to be proved ... in 1953): today the macromolecules described as polymers are known ...
... N.J., Feb. 14, 2012 Laureate Biopharmaceutical ... and manufacturing organization, today announced the appointment ... He will be responsible for continuing Laureate,s ... This will include preparing for upcoming pre-approval ...
Cached Biology Technology:Sloan Research Fellowships Awarded to 126 Young Scholars 2Startling results in synthetic chemistry presented in Nature Chemistry 2Startling results in synthetic chemistry presented in Nature Chemistry 3Laureate Biopharma Appoints Les Mintzmyer, Vice President, Operations 2Laureate Biopharma Appoints Les Mintzmyer, Vice President, Operations 3
Rabbit polyclonal to NMDAR1 e/f/g/h ( Abpromise for all tested applications)....
Purified anti-PI3K p110 delta...
Peptide-affinity Purified Polyclonal Antibody to Histamine H2 Receptor...
Mouse Wnt-9b Biotinylated Affinity Purified PAb ENTREZ GeneID: 22412...
Biology Products: