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Too much sugar turns off gene that controls the effects of sex steroids
Date:11/9/2007

at the University of British Columbia.

With this new understanding, we can now use SHBG as a biomarker for monitoring liver function well before symptoms arise, says Dr Hammond, who is a Tier 1 Canada Research Chair in Reproductive Health. We can also use it for determining the effectiveness of dietary interventions and drugs aimed at improving the livers metabolic state.

Physicians have traditionally measured SHBG in the blood to determine a patients amount of free testosterone, which is key information for diagnosing hormonal disorders. In addition, SHBG levels are used to indicate an individuals risk for developing type 2 diabetes and cardiovascular disease.

The discovery dispels the earlier assumption that too much insulin reduces SHBG, a view which arose from the observation that overweight, pre-diabetic individuals have high levels of insulin and low levels of SHBG. This new study proves that insulin is not to blame and that its actually the livers metabolism of sugar that counts.


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Contact: Jennifer Kohm
jkohm@cw.bc.ca
604-875-2401
Child & Family Research Institute
Source:Eurekalert

Page: 1 2

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