Navigation Links
Too much of a good thing? Too many 'healing' cells delays wound healing
Date:7/1/2013

Bethesda, MD -- Like most other things, you can have too much of a good thing when it comes to wound healing, and new research proves it. According to an article published in the July 2013 issue of the Journal of Leukocyte Biology, wound healing can be delayed because the body produces too many mast cells, which normally promote healing. An overabundance of these cells, however, also causes harm by leading to the overproduction of IL-10, which prevents certain white blood cells from reaching the wounded area. The work was conducted in mice with lymphedematous skin, and may one day provide better treatments for elderly individuals with skin ulcers in the lower extremities, for women with upper-extremity wounds following breast cancer surgery, and skin wounds of any type that are not healing as they should.

"Improvement of lymphedema is important for treatment of skin ulcers," said Makoto Sugaya, M.D., Ph.D., a researcher involved in the work from the Department of Dermatology at the University of Tokyo in Tokyo, Japan. "It is not just fluid retention, but inflammatory cells and cytokines that cause delayed wound healing."

To make this discovery, scientists used two groups of mice. The first group showed severe lymphatic dysfunction. The second group was normal. Researchers administered skin wounds and found that the mice with lymphatic dysfunction showed delayed would healing as compared to the normal mice. Analysis showed that the delayed would healing in the lymphedematous skin is the result of too many mast cells and elevated IL-10 expression, both of which can now be therapeutic targets for future drug development.

"Wound healing is something most people take for granted until there's a problem," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. "However, wound healing is a complex process involving immune as well as non-immune cells a
'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Cant smell anything? This discovery may give you hope
2. UCLA scientists develop new therapeutics that could accelerate wound healing
3. The secrets of a tadpoles tail and the implications for human healing
4. Arginine and proline enriched diet may speed wound healing in diabetes
5. New research association started: Magnesium implants shall facilitate bone fracture healing
6. Healing Method from Australia Addresses the Human Genome
7. Mimicking living cells: Synthesizing ribosomes
8. Type 2 diabetes patients transplanted with own bone marrow stem cells reduces insulin use
9. Organic electronics: Imaging defects in solar cells
10. Research team discovers new kind of signalling mechanism in plant cells
11. Unexpected discovery of the ways cells move could boost understanding of complex diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/29/2014)... Food and Brand Lab pilot study, published in ... National School Lunch Program (NSLP) by 9% and overall ... Move to Schools (CMTS), an initiative of Michelle Obama,s ... to provide nutrition instruction to students and culinary advice ... event was held in an Upstate New York high ...
(Date:9/29/2014)... Texas at Arlington research team says recently identified radiation ... lab could open doors for homeland security and medical ... the Oct. 1 issue of Optics Letters , ... describe a new method to fabricate transparent nanoscintillators by ... a transparent ceramic is formed. A scintillator refers ...
(Date:9/29/2014)... bad rap, and understandably so. The grain-of-rice-sized insects are ... of acres in the Western U.S. and Canada over ... belief, these pests may not be to blame for ... through the region. Instead, weather and topography play a ... these bark-boring beetles. , New research led by the ...
Breaking Biology News(10 mins):Chefs move to schools can increase school meal participation and vegetable intake among students 2UT Arlington researchers develop new transparent nanoscintillators for radiation detection 2UT Arlington researchers develop new transparent nanoscintillators for radiation detection 3Tree killers, yes, fire starters, no: Mountain pine beetles get a bad rap, study says 2Tree killers, yes, fire starters, no: Mountain pine beetles get a bad rap, study says 3Tree killers, yes, fire starters, no: Mountain pine beetles get a bad rap, study says 4
... from Kent State University and the University of ... species Cycloprosopon dobrogea in eastern Romania. Previously unexamined, ... more than 150 million years ago during the ... crabs helps determine various aspects of biodiversity and ...
... St. Paul, Minn. (October 17, 2007) Deadlines ... reservations are quickly approaching for the 2007 National ... Symposium will be held December 12-14, 2007 at ... The 2007 symposium, organized by The American ...
... imagist and researcher at Harvard University,s Initiative in ... the 2007 Lennart Nilsson Award. Frankel was sited ... art and crystal-clear scientific illustrations both fascinating ... community alike. The Lennart Nilsson Award is ...
Cached Biology News:Deadlines for 2007 National Soybean Rust Symposium fast approaching 2Lennart Nilsson Award 2007 2
(Date:10/1/2014)... 2014 Weighing applications in pharmaceutical ... final product. However, while the pharmaceutical industry is ... as Good Manufacturing Practices (GMP) usually provide only ... manufacturer to interpret these guidelines and assess process ... METTLER TOLEDO experts have created a new white ...
(Date:10/1/2014)... -- Pfanstiehl has announced the launch of cGMP-produced, ... USA under ICH Q7 ... playing a key role in protein glycosylation.  Now, ... media supplementation with mannose can improve overall culture ... Dr. Christopher Wilcox , VP, Business Development ...
(Date:10/1/2014)... The participants committed to not only ... their own time adjusting, tweaking and testing virtual models ... ready for judging. , “I enjoyed being involved as ... “The entries showed a commendable range exploring the ... the print medium and the creativity of the contestants.” ...
(Date:10/1/2014)... September 30, 2014 In response ... tools to address sales, training and consumer engagement ... developed innovative mobile applications to turn their clients’ ... agency’s latest customized mobile app creations, are now ... , In partnership with Toyota, StudioPMG created a ...
Breaking Biology Technology:Comply with Weighing-Related Regulations in Pharma Manufacturing 2Pfanstiehl Launches cGMP-produced Mannose for Cell Culture Media Optimization & Glycoprotein Biosynthesis 2Array Architects Challenges Staff to Create with 3D Printer 2Digital Agency Studio PMG Launches New Case Studies on Website 2
... (NASDAQ: LMNX ) today announced that management ... to be held June 4-7 in New York. ... presentation by Patrick J. Balthrop, president and chief executive ... June 6, 2012.  The presentation will be webcast live and ...
... Inc. (Nasdaq: AUXL ) today announced that executive ... to be held June 4-7, 2012 at the Grand Hyatt ... and President, is scheduled to present an overview of the ... Monday, June 4, 2012. A breakout session will be held ...
... Research into conditions such as multiple sclerosis and ... stem cell research and life sciences facilities opened yesterday ... Royal is to unveil plaques this afternoon at the ... $38 million bio-incubator facility, Nine, in Edinburgh. ...
Cached Biology Technology:Luminex Corporation to Present at Jefferies 2012 Global Healthcare Conference 2Auxilium Pharmaceuticals, Inc. to Present at the Jefferies 2012 Global Healthcare Conference 2Auxilium Pharmaceuticals, Inc. to Present at the Jefferies 2012 Global Healthcare Conference 3Auxilium Pharmaceuticals, Inc. to Present at the Jefferies 2012 Global Healthcare Conference 4Scotland opens stem cell research center and bio-medical incubator 2
... plus software to note when an animal is ... and trigger a penaltyThe Spatial Behavior line is ... video camera, frame grabber, and feature extraction software ... and up to 6 moving animals. Software ...
... Magnetofection technology, SilenceMag is the most ... rapid and easy to use, SilenceMag ... Specifically designed for siRNA delivery, SilenceMag ... low doses of siRNA.,SilenceMag formulation gives ...
Denhardt's Solution is a mixture of blocking agents used in membrane-based hybridization protocols. The solution contains 1% Ficoll (type 400) 1% polyvinylpyrrolidone and 1% bovine serum albumin. Ste...
... system from Molecular Devices provides precise dispensing ... The system handles a variety of plate ... and 1536-welland is the first to handle ... optimized to dispense from four different channels ...
Biology Products: