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Tolerance to inhalants may be caused by changes in gene expression
Date:10/17/2007

a relaxed state, gene transcription occurs more frequently.

The researchers predict that increased expression of the slo channels, through epigenetic modifications to the histones, helped neurons recover from sedation and resist the effects of the drug, increasing tolerance.

"While the fruit fly seems very different from us, the cells of its nervous system are remarkably similar to ours and can be used to understand how drugs change our brains," Atkinson said.


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Contact: Nigel Atkinson
nigela@mail.utexas.edu
512-232-3404
University of Texas at Austin
Source:Eurekalert

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