Navigation Links
Tolerance to inhalants may be caused by changes in gene expression
Date:10/17/2007

AUSTIN, Texas--Changes in the expression of genes may be the reason why people who abuse inhalants, such as spray paint or glue, quickly develop a tolerance, biologists at The University of Texas at Austin have discovered.

The team, led by graduate student Yan Wang, used the fruit fly Drosophila melanogaster as a model system to determine how the nervous system becomes tolerant to sedation with organic solvent inhalants.

The team's work appears in the October 16 issue of Public Library of Science-Biology.

"Drug tolerance causes the user to consume more of the drug, speeding them down the path of addiction," said Nigel Atkinson, an associate professor of neurobiology who supervised the research.

This is the first study to show that a single drug experience alters the response of an animal to future doses by epigenetically modifying a single gene.

The research lays the groundwork for understanding mechanisms of inhalant addiction in humans, and it is hoped, developing methods of treatment and recovery. Because the effects of organic solvent inhalants and alcohol on animals are similar, this work may also be relevant to understanding the response of the brain to alcohol.

When fruit flies are sedated with an organic solvent, the expression of the slo K+ channel gene increases. Increased expression of the gene enables the fruit flies to recover faster from sedation. This gene is very similar to the human slo gene.

Wang and colleagues sedated fruit flies with the organic solvent benzyl alcohol, then documented changes in chromosomal structures called histones. Histones are positively charged protein structures that bind to negatively charged DNA. They organize and control access to the DNA.

Benzyl alcohol sedation made the charge of the histone more negative, "relaxing the grip" of the DNA to the histones in a part of the slo gene that controls its expression.

When the chromatin is in
'/>"/>

Contact: Nigel Atkinson
nigela@mail.utexas.edu
512-232-3404
University of Texas at Austin
Source:Eurekalert

Page: 1 2

Related biology news :

1. Mouse with designer liver has enhanced glucose tolerance, insulin response
2. Lactose intolerance linked to ancestral environment
3. UNC launches study of liver injury caused by drugs
4. Oxygen increase caused mammals to triumph, researchers say
5. Blocking the nerve receptor EP1 in mouse models reduces brain damage caused by stroke
6. Stem cell mobilization therapy appears to be ineffective in repairing damage caused by heart attack
7. Whiplash injuries ?are they caused by startle reflexes?
8. Man may have caused pre-historic extinctions
9. Cocaine high caused by interference in neuronal receiving stations
10. Scientists discover new virus caused deaths of transplant recipients from single donor
11. New study may show how to forestall a fatal, virus-caused immune-system meltdown
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/12/2015)... 2015 IriTech, a leading iris based identity ... Texas Instruments Design Network, announced today that the Chief ... IriShield USB MK2120U device during a launching event of ... The iris scanner is manufactured by ... India through its Indian partner, ...
(Date:3/11/2015)... , March 11, 2015   The ... its platform to scientifically measure and harness music ... to real-time biometrics and objective measurements of physiology, ... music at scale in large populations. It is ... technologists and clinicians perform rigorous studies and accelerate ...
(Date:3/5/2015)... 2015 In Brazil , cloud ... using these solutions and 42 percent planning to invest in ... 25 percent of the companies will be investing in these ... of companies in the region are currently opting for the ... will command significant attention in the coming years. This trend ...
Breaking Biology News(10 mins):Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 2Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 3Introducing The Sync Project, a Global Collaboration Harnessing the Scientific Potential of Music for Health 2Introducing The Sync Project, a Global Collaboration Harnessing the Scientific Potential of Music for Health 3Two of Every Three Brazilian Companies will have Invested in Cloud by 2015, Finds Frost & Sullivan 2Two of Every Three Brazilian Companies will have Invested in Cloud by 2015, Finds Frost & Sullivan 3Two of Every Three Brazilian Companies will have Invested in Cloud by 2015, Finds Frost & Sullivan 4
... ROCKVILLE, Maryland July 9, 2009 Human ... the New England Journal of Medicine of ... showed the life-saving potential of the Company,s human monoclonal ... of human safety studies, which supported the use of ...
... appearing in Environmental Health Perspectives (EHP) ... for the Project on Emerging Nanotechnologies (PEN), focuses ... It provides an overview of current practices; ... safety implications; and possible future directions for nanoremediation. ...
... Van Andel Research Institute (VARI) investigators have ... target in the treatment of the most aggressive forms ... few treatment options. "Breast cancer mortality rates are ... traditional treatments tend to be more aggressive and have ...
Cached Biology News:Data published in the New England Journal of Medicine support use of raxibacumab (ABthrax) for the treatment of inhalation anthrax 2Contaminated site remediation: Are nanomaterials the answer? 2Possible drug target found for one of the most aggressive breast cancers 2
(Date:3/26/2015)... 2015 Neogen Corporation (NASDAQ: NEOG ) ... quarter of fiscal 2015, which ended Feb. 28, increased ... $6,575,000. Earnings per share in the current quarter were ... net income increased 17% over prior year to $24,142,000, ... per share, for the same period a year ago. ...
(Date:3/26/2015)... (PRWEB) March 26, 2015 Ale Gicqueau, ... Chen, Director of Clinical Affairs at Align Technology, on ... at the upcoming ACRP 2015 Global Conference and Exhibition ... City, Utah. , During the poster presentation, Ale ... creating and running a Postmarket Registry, the requirements and ...
(Date:3/25/2015)... , March 25, 2015 /PRNewswire/ - SQI Diagnostics Inc. ("SQI" ... as a result of recent discussions with certain shareholders ... of the Company, after dealing with certain matters including ... meeting of shareholders on March 26, 2015 (the "Meeting") ... election of directors will take place when the Meeting ...
(Date:3/25/2015)... 25, 2015 Laboratory workers can ... and Analytical Balances to get best-performing features while ... weighing balances from the trusted brand include: , ... increase your efficiency by providing a large weighing ... Weighing modes include parts counting, percent weighing, checkweighing, ...
Breaking Biology Technology:Neogen reports 13% increase in net income 2Neogen reports 13% increase in net income 3Neogen reports 13% increase in net income 4Neogen reports 13% increase in net income 5Neogen reports 13% increase in net income 6Neogen reports 13% increase in net income 7Neogen reports 13% increase in net income 8Clinovo Presents at ACRP 2015 in Salt Lake City, Utah on April 25th-28th 2Clinovo Presents at ACRP 2015 in Salt Lake City, Utah on April 25th-28th 3SQI Diagnostics Inc. Announces New Nominees to SQI Diagnostics Board and Adjournment of Meeting 2SQI Diagnostics Inc. Announces New Nominees to SQI Diagnostics Board and Adjournment of Meeting 3SQI Diagnostics Inc. Announces New Nominees to SQI Diagnostics Board and Adjournment of Meeting 4SQI Diagnostics Inc. Announces New Nominees to SQI Diagnostics Board and Adjournment of Meeting 5New Economical Top-Loading and Analytical Symmetry Balances from Cole-Parmer 2
... Dec. 5 Representatives from over 40,Shanghai ... attendance, took,part in the first annual Cinpathogen ... hosted by Cinpathogen Inc. and chaired by,Professor ... Epidemiology,Institute, covered current developments in clinical laboratory ...
... ( http://www.CMELLC.com ),a leading provider of fully accredited ... new structure and management team,put in place to ... address the educational needs of healthcare professionals moving,forward., ... role of senior vice,president and general manager, and ...
... $8.1 Million Financing in Connection ... Reverse Stock Split Planned for January 2008, ... today announced that the Company has:, - Signed an agreement ... based in Israel. The acquisition,is expected to close tomorrow. The initial ...
Cached Biology Technology:Cinpathogen Brings Together Over 40 Shanghai Area Hospitals at the First Annual Cinpathogen Hematology Conference 2CME LLC Restructures, Announces Its New Executive Management Team 2Amarin Signs Agreement to Acquire Ester Neurosciences 2Amarin Signs Agreement to Acquire Ester Neurosciences 3Amarin Signs Agreement to Acquire Ester Neurosciences 4Amarin Signs Agreement to Acquire Ester Neurosciences 5Amarin Signs Agreement to Acquire Ester Neurosciences 6Amarin Signs Agreement to Acquire Ester Neurosciences 7Amarin Signs Agreement to Acquire Ester Neurosciences 8Amarin Signs Agreement to Acquire Ester Neurosciences 9Amarin Signs Agreement to Acquire Ester Neurosciences 10Amarin Signs Agreement to Acquire Ester Neurosciences 11
...
PURA Immunogen: PURA (NP_005850, 183 a.a. ~ 293 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
Mouse monoclonal [3F8 ] to smooth muscle Myosin heavy chain I ( Abpromise for all tested applications). entrezGeneID: 4629 SwissProtID: P35749...
Phospho-CD18 (Ser756/Thr758/759) Antibody Shipping Temperature: HOT Storage Temperature: -20C...
Biology Products: