Navigation Links
Tolerance to inhalants may be caused by changes in gene expression
Date:10/17/2007

AUSTIN, Texas--Changes in the expression of genes may be the reason why people who abuse inhalants, such as spray paint or glue, quickly develop a tolerance, biologists at The University of Texas at Austin have discovered.

The team, led by graduate student Yan Wang, used the fruit fly Drosophila melanogaster as a model system to determine how the nervous system becomes tolerant to sedation with organic solvent inhalants.

The team's work appears in the October 16 issue of Public Library of Science-Biology.

"Drug tolerance causes the user to consume more of the drug, speeding them down the path of addiction," said Nigel Atkinson, an associate professor of neurobiology who supervised the research.

This is the first study to show that a single drug experience alters the response of an animal to future doses by epigenetically modifying a single gene.

The research lays the groundwork for understanding mechanisms of inhalant addiction in humans, and it is hoped, developing methods of treatment and recovery. Because the effects of organic solvent inhalants and alcohol on animals are similar, this work may also be relevant to understanding the response of the brain to alcohol.

When fruit flies are sedated with an organic solvent, the expression of the slo K+ channel gene increases. Increased expression of the gene enables the fruit flies to recover faster from sedation. This gene is very similar to the human slo gene.

Wang and colleagues sedated fruit flies with the organic solvent benzyl alcohol, then documented changes in chromosomal structures called histones. Histones are positively charged protein structures that bind to negatively charged DNA. They organize and control access to the DNA.

Benzyl alcohol sedation made the charge of the histone more negative, "relaxing the grip" of the DNA to the histones in a part of the slo gene that controls its expression.

When the chromatin is in
'/>"/>

Contact: Nigel Atkinson
nigela@mail.utexas.edu
512-232-3404
University of Texas at Austin
Source:Eurekalert

Page: 1 2

Related biology news :

1. Mouse with designer liver has enhanced glucose tolerance, insulin response
2. Lactose intolerance linked to ancestral environment
3. UNC launches study of liver injury caused by drugs
4. Oxygen increase caused mammals to triumph, researchers say
5. Blocking the nerve receptor EP1 in mouse models reduces brain damage caused by stroke
6. Stem cell mobilization therapy appears to be ineffective in repairing damage caused by heart attack
7. Whiplash injuries ?are they caused by startle reflexes?
8. Man may have caused pre-historic extinctions
9. Cocaine high caused by interference in neuronal receiving stations
10. Scientists discover new virus caused deaths of transplant recipients from single donor
11. New study may show how to forestall a fatal, virus-caused immune-system meltdown
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/29/2014)... of kidney cancer patients in Europe sheds light on ... an apparent link between exposure to aristolochic acid and ... research, by an international team led by scientists from ... Montreal, underscores the importance of investigating possible sources of ... of the Aristolochia genus, also has been suspected of ...
(Date:10/28/2014)... North America, Europe and China have published a paper ... Sciences that reveals important details about key transitions ... From strange and exotic algae, mosses, ferns, trees and ... and vegetables we eat and the ornamental plants adorning ... a billion years of history., "Our study generated DNA ...
(Date:10/28/2014)... a novel environment are linked to individual differences ... study completed at the University of Eastern Finland ... The study used novel, long-term observations of individual ... analyse if behaviours predict the vulnerability to fishing ... hatchery rearing environments. Based on the results, ...
Breaking Biology News(10 mins):Study sheds light on genetic architecture of kidney cancer 2Study sheds light on genetic architecture of kidney cancer 3New study uses DNA sequences to look back in time at key events in plant evolution 2New study uses DNA sequences to look back in time at key events in plant evolution 3Fish 'personality' linked to vulnerability to angling 2
... have elucidated a key mechanism by which cancer cells ... and raw materials required to sustain runaway growth. ... Ludwig Cancer Research study also reveals how the aggressive ... therapies that should disrupt this capabilityknown as the Warburg ...
... animals will choose to steer clear of dirt but their ... risk of disease as a result. A study of ... near to used nesting material and droppings left by other mice. ... opportunity to eat outweighs an increased risk of disease from other ...
... to learn that individual "molecular muscles" within cells respond to ... cells "feel" the environment and appropriately adapt their shapes and ... 20 in the journal Nature Materials , specifically sheds ... internal signals. A computer model the researchers developed, ...
Cached Biology News:Targeting cancer's sweet tooth 2Targeting cancer's sweet tooth 3Clean living is a luxury wild animals can't afford, study suggests 2Cells' 'molecular muscles' help them sense and respond to their environments 2Cells' 'molecular muscles' help them sense and respond to their environments 3
(Date:10/30/2014)... Oct. 30, 2014 Isis Pharmaceuticals, Inc. (NASDAQ: ... that management will present a company overview at the Nomura ... ET in Boston, MA. ... the "Investors & Media" section of the Company,s website, ... website within 48 hours and will be archived for a ...
(Date:10/30/2014)... flooding that devastated a wide swath of Colorado last ... roads and other infrastructure had been upgraded or modernized, ... Colorado Denver. , "People need to understand the importance ... professor of structural engineering at the CU Denver College ... study. "There is an assumption that a bridge will ...
(Date:10/27/2014)... and TORONTO , Oct. ... www.generex.com ) (OTCQB: GNBT) today announced two presentations ... triggered by its novel proprietary cancer immunotherapeutic AE37 ... breast cancer patients. The AE37 cancer vaccine is ... Express, Inc. ( www.antigenexpress.com ). The presentations are ...
(Date:10/27/2014)... (PRWEB) October 27, 2014 Called ... reducing and eliminating several types of pediatric brain ... been achieved in over 30 years of research ... Light Foundation, proves that one mom's determination can ... just before Halloween trick-or-treating, and it’s only fitting ...
Breaking Biology Technology:Isis Pharmaceuticals to Present at the Nomura Biotechnology Conference 2CU Denver study says upgrading infrastructure could reduce flood damage 2Generex Announces Presentations Correlating Immunological Response with Reduced Recurrence in Phase II Study of AE37 Breast Cancer Vaccine in Patients at the American College of Surgeons 2Generex Announces Presentations Correlating Immunological Response with Reduced Recurrence in Phase II Study of AE37 Breast Cancer Vaccine in Patients at the American College of Surgeons 3Generex Announces Presentations Correlating Immunological Response with Reduced Recurrence in Phase II Study of AE37 Breast Cancer Vaccine in Patients at the American College of Surgeons 4FDA Approves Breakthrough in Pediatric Brain Cancer - First in 30 Years 2FDA Approves Breakthrough in Pediatric Brain Cancer - First in 30 Years 3
... BioMarin,Pharmaceutical Inc. (Nasdaq: BMRN ) today announced ... a company,update at the Credit Suisse 2008 Annual Healthcare ... 10:30 a.m. MST., Interested parties may access a ... section of the BioMarin website, http://www.BMRN.com .,A replay ...
... Stock Exchange Symbol: MS, EDMONTON, Nov. 5 /PRNewswire-FirstCall/ - ... of multiple sclerosis (MS), today,announced that Mr. Kevin Giese, President ... Healthcare Conference in New York., WHEN: ... WHERE: New York Palace Hotel, New York., ...
... that management will present at the following,investor conferences in November., ... New York Palace Hotel Wednesday, November 12, 2008 ... Conference The St. Regis Hotel, New York Tuesday, ... will be audio webcast live and available for replay,from Dendreon,s ...
Cached Biology Technology:BioMarin to Present at the Credit Suisse Healthcare Conference 2BioMS Medical to present at Rodman and Renshaw Annual Healthcare Conference 2
... station, 100-120 V, is used to coat the ... to create the source of the DNA that ... Helios gene gun. The station includes a tubing ... 12 foot Nalgene nitrogen regulator hose, two 0.1875 ...
... 220-240 V, is used for biolistic particle delivery ... an adjustable helium pulse to sweep DNA-, RNA-, ... wall of a small plastic cartridge directly into ... in situ, in vitro, in vivo, and ex ...
... system, 220-240 V, is used for biolistic ... handheld device employs an adjustable helium pulse ... gold microcarriers from the inner wall of ... cells. This system has a 2 square-centimeter ...
The Discovery Series PDQuest 2-D analysis software is used for imaging, analyzing, and databasing two-dimensional electrophoretic gels. The 10-user network license entitles ten users to access data f...
Biology Products: