Navigation Links
To spread, nervous system viruses sabotage cell, hijack transportation
Date:5/30/2012

he neuron on the backs of motor proteins dynein and kinesin-1. During viral infection, mitochondria shed these proteins to stop moving when Miro detects an upsurge in cellular calcium.

Previous research has shown that HSV-1 and PRV also use kinesin-1 specifically for transport within an infected cell. Thus, Kramer said, his and Enquist's work suggests that it is very likely that the viruses disrupt mitochondrial motility so that they can hitch themselves to the now available kinesin-1 proteins and move through the nervous system more efficiently.

James Alwine, a University of Pennsylvania professor of cancer biology, said that the Princeton research is a significant contribution to a growing body of research that describes how viruses seize cellular motor proteins such as kinesin-1.

While the findings have therapeutic potential particularly in helping show how balancing cellular calcium might subdue viral infection the demonstration that viruses can move through an infected cell with the ease of something as essential as mitochondria is notable in itself, said Alwine, who is familiar with the research but had no role in it.

"Determining the specific mechanism by which Miro function is abrogated may provide additional therapeutic avenues, but this also is marvelous basic research that does not have to be justified by its therapeutic potential," he said.

"To disrupt the loading of mitochondria to motor proteins so that virions [complete virus particles] can load instead is a clever way for a virus to be transported and is a great new idea provoked by this data," Alwine said. "While other neurotropic viruses would have to be tested specifically, movement in nerve cells is required by all of them. Thus, this observation provides a starting place and a model mechanism for research with those other pathogens."


'/>"/>

Contact: Morgan Kelly
mgnkelly@princeton.edu
609-258-5729
Princeton University
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Social separation stops flu spread, but must be started soon
2. UC Davis researchers identify a protein that may help breast cancer spread, beat cancer drugs
3. Damage inflicted during cardiac attacks more widespread, MSU researchers find
4. Knee injuries in women linked to motion, nervous system differences
5. Ben-Gurion U. licenses drug delivery platform for central nervous system diseases to NY biotech firm
6. Breakthrough model reveals evolution of ancient nervous systems through seashell colors
7. The battle of the morphogens: How to get ahead in the nervous system
8. A mold on which to create new parts of the puzzle that is the nervous system
9. IRCM researchers uncover a new piece of the puzzle in the development of our nervous system
10. The sweet mysteries of the nervous system
11. Scientists link protein to the insulation of the nervous systems wiring
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
To spread, nervous system viruses sabotage cell, hijack transportation
(Date:7/10/2014)... 2014 Research and Markets ( http://www.researchandmarkets.com/research/h7h8lq/gesture ... "Global Gesture Recognition & Touch-Less Sensing (2D, 3D, ... report to their offering ... & Touch-Less Sensing Market to Grow Exponentially. Touch-less ... but the companies were unable to leverage this ...
(Date:7/10/2014)... July 8, 2014 Fingerprint ... new design win (DW). An Asian OEM has selected FPC1021 ... production start in August 2014.   FPC is ... which has a planned date for start of mass production ... order of SEK 5M, for delivery in the first half ...
(Date:7/10/2014)... large, mainly tropical flowering plant family Melastomataceae (Meadow Beauty Family). ... on bees for their pollination. Only about 100 are known ... of Axinaea appear in clusters of few to ... species are pink, yellow, orange or red. The stamens (male ... their bulbous appendages. The pollination mechanism of Axinaea ...
Breaking Biology News(10 mins):Global Gesture Recognition & Touch-Less Sensing (2D, 3D, Ultrasonic, IR, Capacitive) Market - Forecasts to 2020 2FPC Wins DW and Initial Ramp Order for FPC1021 Touch Sensor for Flagship Smartphone from Asian OEM 2Novel type of bird pollination mechanism discovered in South America 2
... at Texas A&M University College of Veterinary Medicine & Biomedical ... of a foal using oocytes from a live mare, the ... foal highlights Texas A&M,s long tradition of leading science in ... owner of the new foal., "I,ve always liked having three ...
... This release is available in German ... of young researchers in Germany, the Deutsche Forschungsgemeinschaft (DFG, ... Groups. This decision was made by the DFG,s relevant ... will enable doctoral researchers to complete their training at ...
... The mechanism by which ,polycomb, proteins critical for embyronic stem ... identified by UCL scientists. The discovery, which has ... is detailed in research published today in the journal ... stem cells is the suppression of genes that when later ...
Cached Biology News:Texas A&M veterinary researchers achieve cloning first 2Texas A&M veterinary researchers achieve cloning first 3DFG establishes 12 new research training groups 2DFG establishes 12 new research training groups 3DFG establishes 12 new research training groups 4DFG establishes 12 new research training groups 5DFG establishes 12 new research training groups 6How the wrong genes are repressed: New finding from UCL 2
(Date:7/10/2014)... RICHLAND, Wash. The lithium-ion batteries that power our ... run longer on a single charge with the help ... the porous material to replace the graphite traditionally used ... more than 10 times the energy storage capacity of ... lithium-ion battery electrode was published today in Nature ...
(Date:7/10/2014)... Since the 1960s, theatergoers have shelled out for ... to enhance their viewing experience. These basic devices, ... artificial three-dimensional reality, may soon be rendered obsolete ... by Tel Aviv University researchers. , TAU doctoral ... have developed highly efficient holography based on nanoantennas ...
(Date:7/10/2014)... universities and NPL collaborate to bring together their track ... complementary academic strengths., Working with BIS and NPL the ... of the UK. The establishment of a Graduate Institute, ... will provide a pipeline of skilled researchers. Working with ... will be grown through the creation of a series ...
(Date:1/15/2014)... Nobel laureate Herbert Kroemer famously observed, referring to ... junctures where layers of different materials meet. In ... layers of metal oxides are becoming increasingly prominent, ... high-temperature superconductors, ferroelectrics and multiferroics. Realizing the vast ...
Breaking Biology Technology:Silicon sponge improves lithium-ion battery performance 2Silicon sponge improves lithium-ion battery performance 3Projecting a 3-dimensional future 2Projecting a 3-dimensional future 3Universities of Surrey and Strathclyde selected as strategic partners in the future operation of the National Physical Laboratory 2Universities of Surrey and Strathclyde selected as strategic partners in the future operation of the National Physical Laboratory 3A deeper look at interfaces 2
... , , , , Vincent ... Westbury, New York , , , ... Perhaps the most critical parameter for successful , PCR is ... primer can result in a PCR reaction that will not work. The primer sequence , ...
... , , , , Karen Sermon, M.D., PhD ... Hospital and Medical School of the Dutch-speaking Brussels Free , University, , ... , , , , ... Preimplantation diagnosis (PGD) is a very early form of prenatal diagnosis: , ...
... Ends , Using the Eppendorf Mastercycler gradient , ... Ulrich Genschel , Institute of General Botany, University ... , , , , ... In many research projects, cDNA isolation forms the basis for detailed , ...
Cached Biology Technology:General Notes on Primer Design in PCR* 2General Notes on Primer Design in PCR* 3General Notes on Primer Design in PCR* 4General Notes on Primer Design in PCR* 5General Notes on Primer Design in PCR* 6The use of the Mastercycler gradient for single-cell PCR and preimplantation , diagnosis 2The use of the Mastercycler gradient for single-cell PCR and preimplantation , diagnosis 3The use of the Mastercycler gradient for single-cell PCR and preimplantation , diagnosis 4The use of the Mastercycler gradient for single-cell PCR and preimplantation , diagnosis 5Optimizing the Direct Amplification of Missing cDNA 5' Ends, Using the Eppendorf Mastercycler gradient 2Optimizing the Direct Amplification of Missing cDNA 5' Ends, Using the Eppendorf Mastercycler gradient 3Optimizing the Direct Amplification of Missing cDNA 5' Ends, Using the Eppendorf Mastercycler gradient 4Optimizing the Direct Amplification of Missing cDNA 5' Ends, Using the Eppendorf Mastercycler gradient 5
jub, ajuba homolog (Xenopus laevis)...
Prepared in distilled water....
in vitro Translation, Accessory Products...
... The Zero Blunt TOPO ... Sequencing is designed for ... of blunt-end PCR products. ... 5-minute TOPO Cloning and ...
Biology Products: