Navigation Links
To spread, nervous system viruses sabotage cell, hijack transportation
Date:5/30/2012

he neuron on the backs of motor proteins dynein and kinesin-1. During viral infection, mitochondria shed these proteins to stop moving when Miro detects an upsurge in cellular calcium.

Previous research has shown that HSV-1 and PRV also use kinesin-1 specifically for transport within an infected cell. Thus, Kramer said, his and Enquist's work suggests that it is very likely that the viruses disrupt mitochondrial motility so that they can hitch themselves to the now available kinesin-1 proteins and move through the nervous system more efficiently.

James Alwine, a University of Pennsylvania professor of cancer biology, said that the Princeton research is a significant contribution to a growing body of research that describes how viruses seize cellular motor proteins such as kinesin-1.

While the findings have therapeutic potential particularly in helping show how balancing cellular calcium might subdue viral infection the demonstration that viruses can move through an infected cell with the ease of something as essential as mitochondria is notable in itself, said Alwine, who is familiar with the research but had no role in it.

"Determining the specific mechanism by which Miro function is abrogated may provide additional therapeutic avenues, but this also is marvelous basic research that does not have to be justified by its therapeutic potential," he said.

"To disrupt the loading of mitochondria to motor proteins so that virions [complete virus particles] can load instead is a clever way for a virus to be transported and is a great new idea provoked by this data," Alwine said. "While other neurotropic viruses would have to be tested specifically, movement in nerve cells is required by all of them. Thus, this observation provides a starting place and a model mechanism for research with those other pathogens."


'/>"/>

Contact: Morgan Kelly
mgnkelly@princeton.edu
609-258-5729
Princeton University
Source:Eurekalert  

0

GOOD

Page: 1 2 3 4

Related biology news :

1. Social separation stops flu spread, but must be started soon
2. UC Davis researchers identify a protein that may help breast cancer spread, beat cancer drugs
3. Damage inflicted during cardiac attacks more widespread, MSU researchers find
4. Knee injuries in women linked to motion, nervous system differences
5. Ben-Gurion U. licenses drug delivery platform for central nervous system diseases to NY biotech firm
6. Breakthrough model reveals evolution of ancient nervous systems through seashell colors
7. The battle of the morphogens: How to get ahead in the nervous system
8. A mold on which to create new parts of the puzzle that is the nervous system
9. IRCM researchers uncover a new piece of the puzzle in the development of our nervous system
10. The sweet mysteries of the nervous system
11. Scientists link protein to the insulation of the nervous systems wiring
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
To spread, nervous system viruses sabotage cell, hijack transportation
(Date:6/19/2013)... specifically for human consumption qualifies as a gluten-free cereal ... (CD), scientists have confirmed in a study published in ... , Joyce Irene Boye and colleagues point out ... States alone have CD. They develop gastrointestinal and other ... that contain gluten-related proteins. Boye,s team sought to expand ...
(Date:6/19/2013)... ITHACA, N.Y. A Cornell University study offers further ... 4 million to 6 million years ago was profoundly ... in turning genes on and off. , The study, ... evidence for a 40-year-old hypothesis that regulation of genes ... is little difference between humans and chimps in the ...
(Date:6/19/2013)... 2013 Elsevier, a world-leading provider of scientific, technical ... announce the launch of a new open access journal, ... GeoResJ , Elsevier,s earth and planetary science journals ... journal aims to provide a forum for rapid publication ... The journal will be co-edited by six Executive Editors, ...
Breaking Biology News(10 mins):New research backs theory that genetic 'switches' play big role in human evolution 2New research backs theory that genetic 'switches' play big role in human evolution 3
... In a new study suggesting pesticides may be associated ... University of California, Berkeley,s School of Public Health have found ... food crops is related to lower intelligence scores at ... increase in measures of organophosphates detected during a mother,s pregnancy ...
... A pulse oximetry training video produced by Rafael Ortega, ... of anesthesiology at Boston Medical Center (BMC) and professor ... and his colleagues is featured in this week,s ... training video, which is the fifth BMC-produced video to ...
... to air pollution early in life and when a woman ... and may be associated with premenopausal breast cancer later in ... The findings indicated that higher air pollution exposure at birth ... a protein important to the adhesion of cells, a function ...
Cached Biology News:Prenatal pesticide exposure tied to lower IQ in children 2Prenatal pesticide exposure tied to lower IQ in children 3Prenatal pesticide exposure tied to lower IQ in children 4Pulse oximetry training video by BMC anesthesiologist published in NEJM 2Air pollution exposure affects chances of developing premenopausal breast cancer 2
(Date:6/18/2013)... The human skin is the largest organ, yet many ... part. Similar to the liver, or heart, the skin must ... grow. Recent reports from the mankatofreepress.com explained how caring for ... as other life supporting organs. The article suggests several types ... increase the appearance of skin, and fight off acne causing ...
(Date:6/18/2013)... The Pistoia Alliance is ... biomolecular representation standard software toolkit and editor under ... HELM (Hierarchical Editing Language for Macromolecules) enables the ... proteins, nucleotides, antibody drug conjugates) whose size and ... impractical or unusable. HELM solves this problem through ...
(Date:6/18/2013)... 2013 The "Bioinformatics Market By Sector (Molecular ... Tools & Data Analysis Services) & Application (Genomics, Proteomics & ... Market Drivers, Restraints, and Opportunities in North America ... and Rest of World. Browse ... 22 Figures 364 Pages and ...
(Date:6/18/2013)... DUBLIN , June 18, 2013 /PRNewswire/ ... http://www.researchandmarkets.com/research/5g3rx5/dna_sequencing ) has announced the addition of ... Markets and Companies " to their offering. ... This report briefly reviews basics of human ... their applications. Current large and small sequencers ...
Breaking Biology Technology:Natural Acne Remedies Through Diet, Probiotic Action Shares New Insight on What Foods May Help Lead to Clear Skin 2The Pistoia Alliance Releases HELM Biomolecular Representation Standard Open Source Tools 2Bioinformatics Market Worth $7.5 Billion by 2017 2Bioinformatics Market Worth $7.5 Billion by 2017 3DNA Sequencing: Technologies, Markets and Companies - 2013 Report 2
... (Nasdaq: DCTH ) today announced that Jonathan Lewis, M.D., ... the Company, effective December 2, 2008. Dr. Lewis advised the ... result of additional commitments to new leadership positions. , ... , Dr. Harold Koplewicz, Chairman of the ...
... Therapeutics S.A.,(Alternext: ALEHT), a drug and diagnostic discovery company, ... by the INPI (National Institute of,Industrial Property) during the ... "Since its inception, ... value of its intellectual property and in particular from ...
... 3 GlaxoSmithKline,(LSE/NYSE: GSK ) announced today that ... the previously announced tender offer to purchase all of,the outstanding ... GNLB ), for $1.30 per share in cash without interest ... It is a condition to the completion of ...
Cached Biology Technology:Jonathan Lewis, M.D., Ph.D. Steps Down From Delcath Systems Board of Directors 2ExonHit is Honoured by the "Innovation Trophy" From The National Institute of Industrial Property (INPI) 2ExonHit is Honoured by the "Innovation Trophy" From The National Institute of Industrial Property (INPI) 3GlaxoSmithKline Announces Waiver of a Condition to the Tender Offer for Genelabs Technologies, Inc. 2GlaxoSmithKline Announces Waiver of a Condition to the Tender Offer for Genelabs Technologies, Inc. 3
Rabbit anti-Junctophilin-4 (C-term)...
SpectroQuest single beam 4nm UV/Vis spectrophotometer; stand-alone unit; large angled LCD screen; large sample compartment...
... Crystal / Mount is the standard ... is designed especially for the permanent preservation ... sections. It is easy to use and ... is the first aqueous mounting medium that ...
... development to targets including proteins and to ... cancer-specific surface antigens. A&Gs service is ... in approximately 40 days (duration may vary ... Phase I: Immunization, test bleed and ...
Biology Products: