Navigation Links
To spread, nervous system viruses sabotage cell, hijack transportation
Date:5/30/2012

Herpes and other viruses that attack the nervous system may thrive by disrupting cell function in order to hijack a neuron's internal transportation network and spread to other cells.

Princeton University researchers made the first observation in neurons that common strains of the herpes virus indirectly take control of a cell's mitochondria, the mobile organelles that regulate a cell's energy supply, communication with other cells, and self-destruction response to infection. The team reports in the journal Cell Host and Microbe that viral infection elevates neuron activity, as well as the cell's level of calcium a key chemical in cell communication and brings mitochondrial motion to a halt in the cell's axon, which connects to and allows communication with other neurons.

The authors propose that the viruses then commandeer the proteins that mitochondria typically use to move about the cell. The pathogens can then freely travel and reproduce within the infected neuron and more easily spread to uninfected cells. When the researchers made the mitochondria less sensitive to calcium the viruses could not spread as quickly or easily.

These findings reveal a previously unknown and highly efficient mechanism that some of the most common strains of herpes viruses in humans may use to proliferate in the nervous system, said lead author Tal Kramer, a doctoral student in the lab of the paper's co-author Lynn Enquist, the Henry L. Hillman Professor of Molecular Biology and chair of Princeton's molecular biology department.

Kramer and Enquist used rat neurons to study two herpes viruses in the alpha-herpes virus subfamily: pseudorabies virus (PRV), a model alpha-herpes virus that infects animals, and herpes simplex virus 1 (HSV-1), an extremely common human virus that causes cold sores and other lesions. Other human alpha-herpes viruses are responsible for causing diseases such as chicken pox and shingles.

"No one
'/>"/>

Contact: Morgan Kelly
mgnkelly@princeton.edu
609-258-5729
Princeton University
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Social separation stops flu spread, but must be started soon
2. UC Davis researchers identify a protein that may help breast cancer spread, beat cancer drugs
3. Damage inflicted during cardiac attacks more widespread, MSU researchers find
4. Knee injuries in women linked to motion, nervous system differences
5. Ben-Gurion U. licenses drug delivery platform for central nervous system diseases to NY biotech firm
6. Breakthrough model reveals evolution of ancient nervous systems through seashell colors
7. The battle of the morphogens: How to get ahead in the nervous system
8. A mold on which to create new parts of the puzzle that is the nervous system
9. IRCM researchers uncover a new piece of the puzzle in the development of our nervous system
10. The sweet mysteries of the nervous system
11. Scientists link protein to the insulation of the nervous systems wiring
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
To spread, nervous system viruses sabotage cell, hijack transportation
(Date:11/5/2014)... career to understanding the Earth,s climate and communicating ... deputy director and regional climatologist for the Western ... Redmond has more than three decades of experience ... data to the general public. , At its ... December 15-19, 2014 the American Geophysical Union (AGU) ...
(Date:11/4/2014)... School of Medicine announced today that it is ... by the Bill & Melinda Gates Foundation. ... and Reproductive Sciences; and Vice Chair of Research ... Medicine will pursue an innovative global health and ... Assess Fetal Neurodevelopment.", Grand Challenges Explorations (GCE) funds ...
(Date:11/4/2014)... 4, 2014) – A majority of Madagascar,s 101 species ... have serious consequences for the rainforests they call home. ... positive impacts lemurs can have on rainforest tree populations, ... could have on the region,s rich biodiversity. , A ... eaten by lemurs. Lemurs in turn disperse the ...
Breaking Biology News(10 mins):Nevada climatologist to be honored at AGU Fall Meeting for lifetime of public outreach 2Temple University School of Medicine receives Grand Challenges Explorations grant 2Gardeners of Madagascar rainforest at risk 2Gardeners of Madagascar rainforest at risk 3
... 250 million year-old species of large, meat-eating amphibians ... McGill University. Their findings published in today's issue ... carnivores from the Republic of Niger in West ... in this area," says McGill paleontologist, and co-author, ...
... relationship between a wasp species and a newly ... light on how bacteria can be successfully utilized ... microbes. In the new work, researchers show that ... Streptomyces bacteria in unique structures within its antennae ...
... found only in germ-line cells results in infertility in ... from researchers at the University of Pennsylvania School of ... Penn's Center for Research in Reproduction and Women's Health, ... to a new type of contraceptive for both men ...
Cached Biology News:Symbiotic bacteria protect hunting wasps from fungal infestation 2Of mice and men's (and women's) contraceptives 2
(Date:11/21/2014)... 2014 The California Healthcare ... organization representing leading California academic institutions, biotechnology, medical ... US today released a report revealing that ... growth. The trend shows a 4 percent increase ... Biomedical Industry Report indicates that, while biopharmaceutical ...
(Date:11/21/2014)... 2014 2014 Deep Research Report ... a professional and in-depth research report on the ... information, like its definition, classification, application, and industry ... report covers the international market analysis, including China’s ... the US, Europe, Asia, China, Japan etc. regions) ...
(Date:11/21/2014)... (TSXV: BRM) ("Biorem" or "the Company") today announced results for the ... complete 2014 third quarter financial statements and MD&A have been filed ... September 30, , Nine-months ended September 30, ( ... , 2013 , 2014 , 2013 ... 6,715 , 14,476 Gross profit , 521 ...
(Date:11/18/2014)... Athena Signature Series: Turning Cancer ‘Off’ – ... a professor in the Regulatory Biology Laboratory at the Salk ... points to an “off switch” for drug resistance in cancer. ... local research is making a global impact in the fight ... join host Cheryl K. Goodman, CEO of Social Global Mobile ...
Breaking Biology Technology:California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 2California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 3California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 4Sodium Ferrocyanide Market: Analysis for Global & China Regions Development Trends Available at DeepResearchReports.com 2Sodium Ferrocyanide Market: Analysis for Global & China Regions Development Trends Available at DeepResearchReports.com 3Biorem Reports Third Quarter Results 2Biorem Reports Third Quarter Results 3
... SAN FRANCISCO, March 27 Nile Therapeutics, Inc. ... development of novel therapeutics for heart failure patients, announced today ... (IND) application materials that Nile submitted to the U.S. Food ... Company,s Phase IIb clinical trial with CD-NP for the treatment ...
... (Nasdaq: WCRX ) announced today that its ... Drug Application for WC 3016, a low-dose oral contraceptive, ... Warner Chilcott , Warner Chilcott is a ... healthcare and dermatology segments of the U.S. pharmaceuticals market. ...
... Companies Will Offer a Personal Health Record ... Keep ,First Puppy, Healthy and Kissably Sweet ... MMR Information Systems, Inc. (OTC Bulletin ... subsidiary, MyMedicalRecords, Inc. (collectively, "MMR") provides consumer-controlled ...
Cached Biology Technology:Nile Therapeutics Provides Update on Phase II CD-NP Clinical Trial for Acute Heart Failure 2Warner Chilcott Announces NDA Submission for Low Dose Oral Contraceptive 2Warner Chilcott Announces NDA Submission for Low Dose Oral Contraceptive 3MMR and Dancing Paws to Participate in Joint Sales Effort to Provide Personal Health Records for Pets 2MMR and Dancing Paws to Participate in Joint Sales Effort to Provide Personal Health Records for Pets 3MMR and Dancing Paws to Participate in Joint Sales Effort to Provide Personal Health Records for Pets 4
... used to quantitate double-stranded DNA (dsDNA) in solution, ... With this kit, DNA is stained with Hoechst ... VersaFluor or other fluorometer. The kit quantitates dsDNA ... to 5 micrograms per ml and contains Hoechst ...
... stimulating factors for assays of mouse hematopoietic ... fetal liver. Suitable for the growth ... when added to methylcellulose at a final ... Will also support growth of mouse ...
ImmunoPure Plus Immobilized Protein G, , , , Support: Cross-linked 6%, beaded agarose , Capacity: > 20 mg human IgG/ml of gel ...
...
Biology Products: