Navigation Links
To improve lung cancer diagnosis, good medicine is a polymer pill
Date:4/28/2010

Doctors may soon be able to diagnose lung cancer more effectively thanks to research performed at the National Institute of Standards and Technology (NIST), where scientists have found ways both to increase the accuracy of computed tomography (CT) scans and to lessen the amount of time necessary to perceive telltale changes in lung tissue.*

For years, radiologists have determined the size of potentially cancerous lung nodules by measuring the largest distance across them as displayed on a computer screen in two dimensions. A method called RECIST is widely used for this purpose, but some members of the research community have suggested that three-dimensional analysis, or volumetrics, may provide a better way to determine the size of the nodules. Recently, a NIST team quantified this improvement: Volumetrics could allow physicians to notice volume changes that are up to 10 times smaller than RECIST can, potentially cutting diagnosis time from six months to four weeksa critical difference in terms of a patient's chance of survival.

CT scans combine a series of X-ray views taken from many different angles to produce cross-sectional images of the body, but there are several approaches to interpreting scan data, so NIST's Zachary Levine set out to determine which was best by creating a set of reference objects that could mimic potential lung tumors. His team measured 283 polymer-silicate ellipsoids of precise volume that resemble pills ranging from four to 11 mm in diameter.

"For diagnosis in the earliest stage of cancer, other studies have shown this is the size of nodule you want to be looking at," says Levine.

The team encased the mimics in foam rubber and put them into layered racks of a box akin to one that holds fishing tackle. Because foam appears transparent to the CT reconstruction, in a scan the denser mimics look very much like tumors. The team was then able to compare their ellipsoids' known volumes with what the volumetrics and RECIST methods indicated from the scan data.

"We found that volumetrics allows you to notice volume changes that are a factor of 10 smaller than RECIST can with a similar level of confidence," Levine says. "This implies that you could notice life-threatening changes from a follow-up scan performed only weeks after the first, instead of months."

Levine cautions that cancers often grow in strange shapes not resembling elliptical pills which can make a diagnosis more difficult, but that the study was a good start toward improving data interpretation.

"Our work only applies to the simplest of cases, but it's still a large class of lung cancers," he says.


'/>"/>

Contact: Chad Boutin
boutin@nist.gov
301-975-4261
National Institute of Standards and Technology (NIST)
Source:Eurekalert  

Related biology news :

1. Primary Energy Reports Improved First Quarter Results
2. Drinking 100 percent fruit juice is associated with improved diet quality in children
3. New adult malnutrition strategies could improve diagnosis and treatment
4. New survey techniques improve narwhal population estimates
5. Genetic key discovered to dramatically increase yields and improve taste of hybrid tomato plants
6. VARI study could improve treatments for prostate cancer
7. Second plant pathway could improve nutrition, biofuel production
8. Study uses Chinese wolfberries to improve vision imperfections caused by type-2 diabetes
9. Researchers introducing sustainable agriculture practices to improve food security
10. Research points to way to improve heart treatment
11. TU Delft improves production of chemicals from wood waste
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
To improve lung cancer diagnosis, good medicine is a polymer pill
(Date:3/22/2017)... Calif. , March 21, 2017 ... analytics company serving law enforcement agencies, announced today the ... as director of public safety business development. ... diversified law enforcement experience, including a focus on the ... In his most recent position, Mr. Sheridan served as ...
(Date:3/13/2017)... HAMBURG, Germany , March 13, 2017 Future of ... ... DERMALOGs Face Matching enables to match ... characteristics forms the basis to identify individuals. (PRNewsFoto/Dermalog Identification Systems) ... DERMALOG,s "Face Matching" is the fastest software for ...
(Date:3/7/2017)... CITY , March 7, 2017   HireVue ... help top global companies identify the best talent, faster, ... as Chief Sales Officer (CSO) and Diana Kucer ... appointments round out a seasoned executive team poised to drive ... beyond, building on a year of record bookings in ...
Breaking Biology News(10 mins):
(Date:4/27/2017)... ... 27, 2017 , ... Volunteers supported by SPIE, the ... industry professionals in visiting U.S. Congressional offices in Washington, D.C., yesterday to urge ... industry. , This year, National Photonics Initiative (NPI) Congressional Visits Day ...
(Date:4/26/2017)... ... April 26, 2017 , ... ... with NASA to showcase the future of deep space exploration and inspire space ... and Orion spacecraft and includes a guest appearance by former Shuttle Astronaut Don ...
(Date:4/26/2017)... ... April 26, 2017 , ... As the ... among healthcare industry stakeholders, the discussion surrounding the topic will continue at WEDI ... 2017 in Los Angeles, Calif. Hosted by the Workgroup for Electronic Data Interchange ...
(Date:4/25/2017)... 25, 2017 Providence ... its novel immune-modulating technology to an undisclosed global pharmaceutical ... Tregitopes, pronounced T·rej·itopes, are a set ... EpiVax CEO Annie De Groot and ... G, an autoimmune disease therapy, Tregitopes are capable ...
Breaking Biology Technology: