Navigation Links
To have or not to have ribs (a vertebrate story)
Date:4/27/2010

Like all vertebrates, snakes, mice and humans have in common a skeleton made of segments, the vertebrae. But a snake has between 200-400 ribs extending from all vertebrae, from the neck to the tail-end, whereas mice have only 13 pairs of ribs, and humans have 12 pairs, in both cases making up the ribcage. In the latest issue of Developmental Cell(*), researchers from the Instituto Gulbenkian de Cincia, in Portugal, reveal that, contrary to what was thought, making ribs is not the default state for vertebrates, but is actually an active process of balancing the activities of a remarkable class of genes - the Hox genes.

It was thought that the rib less region of the mouse embryo was the result of a rib-inhibiting programme, driven by Hox10 genes. Indeed, previous studies, in which Hox10 genes were inactivated in the embryo, generated mice with extra ribs. However, by forcing another class of Hox genes (Hox6) to be activated in future rib-less regions of the mouse embryo, Moises Mallo and his team bred mice that also have extra ribs, both in the neck area, and from just after the rib cage, all the way down to the tail, resembling a snake-like skeleton.

'It was an extraordinary, and clear-cut result', says Mallo, 'suggesting that these two groups of Hox genes balance each other out: one actively promotes rib formation to produce the thoracic region, while the other blocks this activity in the lumbar region. Our results have unveiled this balance.'

The researchers went on to unpick the genes involved in this process, and came up with yet another surprising finding: that the whole process relies on first hitting so-called muscle genes in the embryo, which then provide signals to switch on the 'rib' genes to make both ribs and muscle, in a coordinated process.

According to Mallo, 'Our findings reveal a more complicated process than we would have imagined, but one that makes perfect sense, from a functional and evolutionary point of view: it is no good to make ribs without muscle, so, in the embryo, the production of both ribs and their associated muscles is under the control of a single and coordinated mechanism.


'/>"/>

Contact: Ana Godinho
agodinho@igc.gulbenkian.pt
351-214-407-959
Instituto Gulbenkian de Ciencia
Source:Eurekalert  

Related biology news :

1. Dartmouth researchers find the root of the evolutionary emergence of vertebrates
2. Scientists find 245 million-year-old burrows of land vertebrates in Antarctica
3. Genome sequence of small marine creature sheds light on vertebrate origins
4. Unheard of life history for a vertebrate
5. Ancient marine invertebrate diversity less explosive than thought
6. Digital zebrafish embryo provides the first complete developmental blueprint of a vertebrate
7. New molecular insight into vertebrate brain development
8. The evolutionary foundation of genomic imprinting in lower vertebrates
9. Singapore scientists join international study of 10,000 vertebrates genomes
10. Tool use in an invertebrate: The coconut-carrying octopus
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
To have or not to have ribs (a vertebrate story)
(Date:2/2/2016)... Feb. 2, 2016  Based on its recent ... Sullivan recognizes US-based Intelligent Retinal Imaging Systems (IRIS) ... Award for New Product Innovation. IRIS, a prominent ... North America , is poised to set ... diabetic retinopathy market. The IRIS technology presents superior ...
(Date:1/28/2016)... JOSE, Calif., Jan. 28, 2016 Synaptics (NASDAQ: SYNA ... results for its second quarter ended December 31, 2015. ... second quarter of fiscal 2016 increased 2 percent compared to the ... second quarter of fiscal 2016 was $35.0 million, or $0.93 per ... Non-GAAP net income for the first quarter of fiscal 2016 grew ...
(Date:1/22/2016)... 22, 2016 ... of the  "Global Behavioral Biometric Market ... --> http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ) has announced ... Biometric Market 2016-2020"  report to their ... Markets ( http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ) has announced the ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... , Germany and ... QGEN ; Frankfurt Prime Standard: QIA) today ... Targeted RNA Panels for gene expression profiling, expanding QIAGEN,s ... (NGS). The panels enable researchers to select from over ... changes and discover interactions between genes, cellular phenotypes and ...
(Date:2/11/2016)... 11, 2016  Dovetail Genomics™ LLC today announced that ... for a planned metagenomic genome assembly service. Richard ... genome assembly method in a talk on Friday, February ... Technology conference in Orlando, Fla. ... datasets is difficult. Using its proprietary Chicago ...
(Date:2/11/2016)... (PRWEB) , ... February 11, 2016 , ... ... of its new stem cell treatment clinic in Quito, Ecuador. The new facility ... and trauma applications to patients from around the world. , The new ...
(Date:2/10/2016)... , Feb.10, 2016 ASAE is introducing ... Association Management Companies (AMC) the option of joining or ... annual fee determined by staff size, every employee in ... join ASAE and reap all available member benefits.   ... "Our new organizational membership options will allow organizations of ...
Breaking Biology Technology: