Navigation Links
To have or not to have ribs (a vertebrate story)
Date:4/27/2010

Like all vertebrates, snakes, mice and humans have in common a skeleton made of segments, the vertebrae. But a snake has between 200-400 ribs extending from all vertebrae, from the neck to the tail-end, whereas mice have only 13 pairs of ribs, and humans have 12 pairs, in both cases making up the ribcage. In the latest issue of Developmental Cell(*), researchers from the Instituto Gulbenkian de Cincia, in Portugal, reveal that, contrary to what was thought, making ribs is not the default state for vertebrates, but is actually an active process of balancing the activities of a remarkable class of genes - the Hox genes.

It was thought that the rib less region of the mouse embryo was the result of a rib-inhibiting programme, driven by Hox10 genes. Indeed, previous studies, in which Hox10 genes were inactivated in the embryo, generated mice with extra ribs. However, by forcing another class of Hox genes (Hox6) to be activated in future rib-less regions of the mouse embryo, Moises Mallo and his team bred mice that also have extra ribs, both in the neck area, and from just after the rib cage, all the way down to the tail, resembling a snake-like skeleton.

'It was an extraordinary, and clear-cut result', says Mallo, 'suggesting that these two groups of Hox genes balance each other out: one actively promotes rib formation to produce the thoracic region, while the other blocks this activity in the lumbar region. Our results have unveiled this balance.'

The researchers went on to unpick the genes involved in this process, and came up with yet another surprising finding: that the whole process relies on first hitting so-called muscle genes in the embryo, which then provide signals to switch on the 'rib' genes to make both ribs and muscle, in a coordinated process.

According to Mallo, 'Our findings reveal a more complicated process than we would have imagined, but one that makes perfect sense, from a functional and evolutionary
'/>"/>

Contact: Ana Godinho
agodinho@igc.gulbenkian.pt
351-214-407-959
Instituto Gulbenkian de Ciencia
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Dartmouth researchers find the root of the evolutionary emergence of vertebrates
2. Scientists find 245 million-year-old burrows of land vertebrates in Antarctica
3. Genome sequence of small marine creature sheds light on vertebrate origins
4. Unheard of life history for a vertebrate
5. Ancient marine invertebrate diversity less explosive than thought
6. Digital zebrafish embryo provides the first complete developmental blueprint of a vertebrate
7. New molecular insight into vertebrate brain development
8. The evolutionary foundation of genomic imprinting in lower vertebrates
9. Singapore scientists join international study of 10,000 vertebrates genomes
10. Tool use in an invertebrate: The coconut-carrying octopus
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
To have or not to have ribs (a vertebrate story)
(Date:5/28/2015)... , May 28, 2015 Industry ... of a new report titled "Markets for Self-Healing ... polymers, inorganic capsule and vascular systems, biomaterials, relevant ... grow to around $2.7 billion by 2020. ... n-tech,s extensive coverage of smart materials. Other recent n-tech ...
(Date:5/22/2015)... , May 22, 2015 According ... by Solution (2D, 3D, Thermal, Emotion, Forensic), by Software (Middleware, ... (Government and Utilities, Consumer and Home) - Global Forecast ... grow from $2.77 Billion in 2015 to $6.19 Billion ... Browse 79 market data Tables and   43 ...
(Date:5/19/2015)... 18, 2015 Fingerprint Cards (FPC) has ... FPC1145, FPC1155 and FPC1035 from one if its module partners. ... including Q3 2015 and the sensors will be used by ... values for 2015 hereby amount to 740 MSEK to date. ... 140 MSEK and a number of smaller orders not separately ...
Breaking Biology News(10 mins):The Market for Self-Healing Materials to Reach $2.7 Billion by 2020 Says New n-tech Research Study 2The Market for Self-Healing Materials to Reach $2.7 Billion by 2020 Says New n-tech Research Study 3Facial Recognition Market Worth $6.19 Billion by 2020 2Facial Recognition Market Worth $6.19 Billion by 2020 3Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2
... resistance in bacteria may also be involved in exporting ... quorum sensing, said researchers from Baylor College of Medicine ... Proceedings of the National Academy of Sciences. , "We ... actually be similar in structure to molecules involved in ...
... bugs targeted by vaccines recently announced by the Department ... scientists from the Wellcome Trust Sanger Institute. They have ... the vaccine that will help monitor the disease and ... name Streptococcus pneumoniae) are widespread, causing non-invasive disease, such ...
... a key component of the mechanism spermatozoa use to ... undulation to the whip-cracking snap that thrusts them into ... that the researchers said could help scientists both recognize ... to thwart sperm entry into the egg. , What's ...
Cached Biology News:Drug resistance may travel same path as quorum sensing 2Outsmarting the smartie bug 2Outsmarting the smartie bug 3How sperm crack the whip 2How sperm crack the whip 3
(Date:6/3/2015)... Marktech Optoelectronics is pleased to introduce a new ... internal gain mechanism, fast time response, low dark current ... APD’s are recommended for applications that require high bandwidth, ... pre-amp noise. In addition, Marktech APD's provide higher sensitivity ... low-level light detection and short pulse detection. , ...
(Date:6/3/2015)... June 03, 2015 From smart street ... important part in enabling success in dealing with important ... technology leaders helped bring focus to the role and ... Photonics21 annual meeting last week in Brussels. ... event, held 28 and 29 May at the Hotel ...
(Date:6/2/2015)... MIAMI (PRWEB) June 02, 2015 Global ... Latin America distributor for Bioquark, Inc.’s biologic products for the ... is the latest in Global Stem Cells Group’s ambitious expansion ... region’s growing demand for access to regenerative medicine and stem ... on the development of biologics that have the ability to ...
(Date:6/2/2015)... June 02, 2015 Research and Markets( ... PharmaBiotech,s new report "Biomarkers - Technologies, Markets ... This report follows the broad definition of a ... measured and evaluated as an indicator of normal ... responses to a therapeutic intervention. Tests based on ...
Breaking Biology Technology:Marktech Introduces New Line of APDs 2Photonics21 Annual Meeting Focuses on Solutions for ‘Societal Challenges’ 2Photonics21 Annual Meeting Focuses on Solutions for ‘Societal Challenges’ 3Adimarket Named Latin American Distributor for Bioquark Biologic Products for the Regeneration and Repair of Human Organs and Tissue with Stem Cells 2Adimarket Named Latin American Distributor for Bioquark Biologic Products for the Regeneration and Repair of Human Organs and Tissue with Stem Cells 3Global Biomarkers Market Report 2015 - Technologies, Markets and Companies Analysis and Forecasts 2014-2024 2Global Biomarkers Market Report 2015 - Technologies, Markets and Companies Analysis and Forecasts 2014-2024 3
... Novo Nordisk, a,healthcare company with an 84-year history ... the appointment of Alan C. Moses, M.D. as,vice ... the,chief medical officer of Novo Nordisk Inc., the ... talent to integrate the science of discovery with,new ...
... Dx Breast Cancer Profile Represents First Molecular ... Stages of Operable Breast Cancer, ALISO VIEJO, Calif., ... premier technology and services resource for,pathologists, oncologists and the ... breast cancer test, the first molecular,test available that is ...
... Banking acted as,exclusive financial advisor to NPS Pharmaceuticals ... the terms of the agreement, NPS has licensed ... the treatment of gastrointestinal disorders., Gattex is ... of,short-bowel syndrome (SBS). SBS can result from one ...
Cached Biology Technology:Novo Nordisk Appoints Alan C. Moses as Chief Medical Officer Worldwide 2Clarient to Commercialize Novel Breast Cancer Profile 2Clarient to Commercialize Novel Breast Cancer Profile 3Clarient to Commercialize Novel Breast Cancer Profile 4Clarient to Commercialize Novel Breast Cancer Profile 5Burrill Merchant Banking Advises NPS on Phase III Licensing Agreement 2
... analysis of gene expression) technology ... Expression profiles generated by SAGE ... low-abundance transcripts making it possible ... I-SAGE Kit is designed to ...
...
Human PDGF, CF...
... The mycobacteria in Complete Freund's adjuvant attract ... site which enhances the immuneresponse. For this ... for the initial injections; Incomplete Freund's adjuvant ... (preferably in saline) are typically mixed with ...
Biology Products: