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To cap or not to cap: Scientists find new RNA phenomenon that challenges dogma
Date:8/27/2012

ngertip, where they are then activated to make new proteins.

"What would the condition be of the mRNA to keep it silent? The possibility is it doesn't have a cap on it, and if it doesn't, it can't be translated. Maybe cytoplasmic capping in neurons is a function that allows that message to be translated at just the right time," Schoenberg said.

Or, in the case of cancer: "What if one of the things that happens is you are making shortened proteins instead of full-length proteins and the regulatory part of the protein is missing in the shortened protein? If that's true, can you interfere with this process and interfere with malignancy as a result?"

For now, these scientists can only speculate about what this unexpected biological process really means. Schoenberg's lab plans to investigate the phenomenon more thoroughly in a line of breast cancer cells.


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Contact: Daniel Schoenberg
Schoenberg.3@osu.edu
614-688-3012
Ohio State University
Source:Eurekalert

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