Navigation Links
Tissue regeneration using anti-inflammatory nanomolecules

Anyone who has suffered an injury can probably remember the after-effects, including pain, swelling or redness. These are signs that the body is fighting back against the injury. When tissue in the body is damaged, biological programs are activated to aid in tissue regeneration. An inflammatory response acts as a protective mechanism to enable repair and regeneration, helping the body to heal after injuries such as wounds and burns. However, the same mechanism may interfere with healing in situations in which foreign material is introduced, for example when synthetics are grafted to skin for dermal repair. In such cases, the inflammation may lead to tissue fibrosis, which creates an obstacle to proper physiological function.

The research group of Arun Sharma, PhD has been working on innovative approaches to tissue regeneration in order to improve the lives of patients with urinary bladder dysfunction. Among their breakthroughs was a medical model for regenerating bladders using stem cells harvested from a donor's own bone marrow, reported in the Proceedings of the National Academy of Sciences in 2013.

More recently, the team has developed a system that may protect against the inflammatory reaction that can negatively impact tissue growth, development and function. Self-assembling peptide amphiphiles (PAs) are biocompatible and biodegradable nanomaterials that have demonstrated utility in a wide range of settings and applications. Using an established urinary bladder augmentation model, the Sharma Group treated a highly pro-inflammatory biologic scaffold used in a wide array of settings with anti-inflammatory peptide amphiphiles (AIF-PAs). When compared with control PAs, the treated scaffold showed regenerative capacity while modulating the innate inflammatory response, resulting in superior bladder function.

This work is published in the journal Biomaterials. Says Sharma, "Our findings are very relevant not just for bladder regeneration but for other types of tissue regeneration where foreign materials are utilized for structural support. I also envision the potential utility of these nanomolecules for the treatment of a wide range of dysfunctional inflammatory based conditions."


Contact: Peggy Murphy
Children's Memorial Hospital

Related biology news :

1. Dynamic culture of a thermosensitive collagen hydrogel improves tissue-engineered peripheral nerve
2. Biology made simpler with clear tissues
3. University of Houston researcher publishes textbook on tissue engineering
4. Enhanced NIST instrument enables high-speed chemical imaging of tissues
5. Novel methods may help stem cells survive transplantation into damaged tissues
6. Interleukin-10 aids survival of cells transplanted to repair cardiac tissues after MI
7. New professorship in tissue engineering links molecular engineering, marine biology
8. A step closer to bio-printing transplantable tissues and organs: Study
9. CWRU engineer to grow replacement tissue for torn rotator cuffs
10. Better tissue healing with disappearing hydrogels
11. Biomarkers accurately distinguish mesothelioma from non-cancerous tissue
Post Your Comments:
(Date:6/30/2017)... Today, American Trucking Associations announced Seeing ... and eye tracking software, became the newest member ... "Artificial intelligence and advanced sensing algorithms ... driver,s attentiveness levels while on the road.  Drivers ... fatigue and prevent potential accidents, which could lead ...
(Date:5/16/2017)... , May 16, 2017  Veratad Technologies, LLC ... of online age and identity verification solutions, announced today ... Identity Conference 2017, May 15 thru May 17, 2017, ... Building and International Trade Center. Identity ... globe and in today,s quickly evolving digital world, defining ...
(Date:4/19/2017)... , April 19, 2017 The ... vendor landscape is marked by the presence of several ... however held by five major players - 3M Cogent, ... companies accounted for nearly 61% of the global military ... companies in the global military biometrics market boast global ...
Breaking Biology News(10 mins):
(Date:10/9/2017)... ... October 09, 2017 , ... The award-winning American Farmer ... first quarter 2018. American Farmer airs Tuesdays at 8:30aET on RFD-TV. , With ... with the challenge of how to continue to feed a growing nation. At the ...
(Date:10/9/2017)... Antonio, Texas (PRWEB) , ... ... ... new study published on October 5, 2017, in the medical journal, Epilepsia, ... equivalence with the gold standard, video EEG, in detecting generalized tonic-clonic seizures ...
(Date:10/7/2017)... Oct. 6, 2017  The 2017 Nobel Prize ... scientists, Jacques Dubochet, Joachim Frank and ... cryo-electron microscopy (cryo-EM) have helped to ... structural biology community. The winners worked with systems ... routinely produce highly resolved, three-dimensional images of protein ...
(Date:10/5/2017)... (PRWEB) , ... October 05, 2017 , ... LabRoots ... and scientists from around the world, is giving back to cancer research with a ... October. , Now through October 31, shoppers can use promo code PinkRibbon to ...
Breaking Biology Technology: