Navigation Links
Tissue regeneration using anti-inflammatory nanomolecules
Date:8/22/2014

Anyone who has suffered an injury can probably remember the after-effects, including pain, swelling or redness. These are signs that the body is fighting back against the injury. When tissue in the body is damaged, biological programs are activated to aid in tissue regeneration. An inflammatory response acts as a protective mechanism to enable repair and regeneration, helping the body to heal after injuries such as wounds and burns. However, the same mechanism may interfere with healing in situations in which foreign material is introduced, for example when synthetics are grafted to skin for dermal repair. In such cases, the inflammation may lead to tissue fibrosis, which creates an obstacle to proper physiological function.

The research group of Arun Sharma, PhD has been working on innovative approaches to tissue regeneration in order to improve the lives of patients with urinary bladder dysfunction. Among their breakthroughs was a medical model for regenerating bladders using stem cells harvested from a donor's own bone marrow, reported in the Proceedings of the National Academy of Sciences in 2013.

More recently, the team has developed a system that may protect against the inflammatory reaction that can negatively impact tissue growth, development and function. Self-assembling peptide amphiphiles (PAs) are biocompatible and biodegradable nanomaterials that have demonstrated utility in a wide range of settings and applications. Using an established urinary bladder augmentation model, the Sharma Group treated a highly pro-inflammatory biologic scaffold used in a wide array of settings with anti-inflammatory peptide amphiphiles (AIF-PAs). When compared with control PAs, the treated scaffold showed regenerative capacity while modulating the innate inflammatory response, resulting in superior bladder function.

This work is published in the journal Biomaterials. Says Sharma, "Our findings are very relevant not just for bladder regeneration but for other types of tissue regeneration where foreign materials are utilized for structural support. I also envision the potential utility of these nanomolecules for the treatment of a wide range of dysfunctional inflammatory based conditions."


'/>"/>

Contact: Peggy Murphy
pemurphy@luriechildrens.org
773-755-7485
Children's Memorial Hospital
Source:Eurekalert

Related biology news :

1. Dynamic culture of a thermosensitive collagen hydrogel improves tissue-engineered peripheral nerve
2. Biology made simpler with clear tissues
3. University of Houston researcher publishes textbook on tissue engineering
4. Enhanced NIST instrument enables high-speed chemical imaging of tissues
5. Novel methods may help stem cells survive transplantation into damaged tissues
6. Interleukin-10 aids survival of cells transplanted to repair cardiac tissues after MI
7. New professorship in tissue engineering links molecular engineering, marine biology
8. A step closer to bio-printing transplantable tissues and organs: Study
9. CWRU engineer to grow replacement tissue for torn rotator cuffs
10. Better tissue healing with disappearing hydrogels
11. Biomarkers accurately distinguish mesothelioma from non-cancerous tissue
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/9/2016)... , March 9, 2016 ... government identified that more than 23,000 public service employees ... had been receiving their salary unlawfully.    --> ... country,s government identified that more than 23,000 public service ... or had been receiving their salary unlawfully.    ...
(Date:3/3/2016)... 3, 2016  FlexTech, a SEMI Strategic Association Partner, ... Research & Development, Leadership in Education, and, in a ... 9 th year of the FLEXI Awards and ... individuals from past years . Judging was done ... set of criteria, by a panel of non-affiliated, independent, ...
(Date:3/2/2016)... 2, 2016 ... of the  "Global Biometrics Market in Hospitality ... (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , , Global biometrics market ... a CAGR of around 27%   ... announced the addition of the  "Global Biometrics ...
Breaking Biology News(10 mins):
(Date:5/4/2016)... New York, NY (PRWEB) , ... May 04, 2016 , ... ... neurofibromatosis (NF), a genetic disorder that causes tumors to grow on nerves throughout the ... treatment or cure. , Through numerous community events held during the month of May, ...
(Date:5/4/2016)... ... May 04, 2016 , ... Nutrafol®, ... to help treat hormonal and stress related hair loss. With patent-pending formulas for ... of key opinion leaders in the medical and salon channels nationwide. , ...
(Date:5/3/2016)... ... ... In a list published by the Boston Business Journal, iLab Solutions ... percentage of the state's 615,000+ small businesses. The list examined companies based in the ... to 2015. , As this award comes on the heels of iLab’s ...
(Date:5/3/2016)... ... May 03, 2016 , ... Kerafast Inc., ... materials from laboratories across the globe, today announced the availability of a Zika ... of research toward treatment and prevention measures for the Zika virus, the virus’s ...
Breaking Biology Technology: