Navigation Links
Tissue regeneration using anti-inflammatory nanomolecules
Date:8/22/2014

Anyone who has suffered an injury can probably remember the after-effects, including pain, swelling or redness. These are signs that the body is fighting back against the injury. When tissue in the body is damaged, biological programs are activated to aid in tissue regeneration. An inflammatory response acts as a protective mechanism to enable repair and regeneration, helping the body to heal after injuries such as wounds and burns. However, the same mechanism may interfere with healing in situations in which foreign material is introduced, for example when synthetics are grafted to skin for dermal repair. In such cases, the inflammation may lead to tissue fibrosis, which creates an obstacle to proper physiological function.

The research group of Arun Sharma, PhD has been working on innovative approaches to tissue regeneration in order to improve the lives of patients with urinary bladder dysfunction. Among their breakthroughs was a medical model for regenerating bladders using stem cells harvested from a donor's own bone marrow, reported in the Proceedings of the National Academy of Sciences in 2013.

More recently, the team has developed a system that may protect against the inflammatory reaction that can negatively impact tissue growth, development and function. Self-assembling peptide amphiphiles (PAs) are biocompatible and biodegradable nanomaterials that have demonstrated utility in a wide range of settings and applications. Using an established urinary bladder augmentation model, the Sharma Group treated a highly pro-inflammatory biologic scaffold used in a wide array of settings with anti-inflammatory peptide amphiphiles (AIF-PAs). When compared with control PAs, the treated scaffold showed regenerative capacity while modulating the innate inflammatory response, resulting in superior bladder function.

This work is published in the journal Biomaterials. Says Sharma, "Our findings are very relevant not just for bladder rege
'/>"/>

Contact: Peggy Murphy
pemurphy@luriechildrens.org
773-755-7485
Children's Memorial Hospital
Source:Eurekalert

Page: 1 2

Related biology news :

1. Dynamic culture of a thermosensitive collagen hydrogel improves tissue-engineered peripheral nerve
2. Biology made simpler with clear tissues
3. University of Houston researcher publishes textbook on tissue engineering
4. Enhanced NIST instrument enables high-speed chemical imaging of tissues
5. Novel methods may help stem cells survive transplantation into damaged tissues
6. Interleukin-10 aids survival of cells transplanted to repair cardiac tissues after MI
7. New professorship in tissue engineering links molecular engineering, marine biology
8. A step closer to bio-printing transplantable tissues and organs: Study
9. CWRU engineer to grow replacement tissue for torn rotator cuffs
10. Better tissue healing with disappearing hydrogels
11. Biomarkers accurately distinguish mesothelioma from non-cancerous tissue
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/11/2014)... Markets , http://photos.prnewswire.com/prnh/20130307/600769 ... addition of the "Biometrics Market in India 2015-2019" ... major trend emerging in this market is the adoption ... than one characteristic of an individual for verification and ...
(Date:12/10/2014)... 8, 2014 You,ve been here before: you desperately need to ... site key or the answer to your secret question. What,s your ... Today, Hoyos Labs , a digital infrastructure security company, launches ... the frustration that comes with usernames, passwords and PINs – ...
(Date:12/10/2014)... SAN DIEGO , Dec. 9, 2014 CIE San ... that provides the connective tissue that enhances care coordination among ... share client-level information; earned a second $1 million grant from ... aging in community and; will be recognized as a "Live ...
Breaking Biology News(10 mins):Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4
... New Rochelle, NY, June 7, 2011Increasingly sophisticated imaging ... to probe the organization and activity of the brain ... better understanding of the complex networks that link brain ... are contributing to new insights into brain function throughout ...
... COLUMBUS, Ohio From the paleolithic diet to the raw food ... believe our ancient ancestors ate. But some of these dietary ... book on the evolution of the use of food and eating ... learn from what our ancestors ate, many of our more modern ...
... Scientists worldwide have been working on the publicly ... O104 strain, which is causing the current health ... continue to speed the ongoing international efforts of researchers ... their collaborators at the University Medical Centre Hamburg-Eppendorf have ...
Cached Biology News:Emerging research in brain connectivity reveals new understanding of neurological disorders 2Emerging research in brain connectivity reveals new understanding of neurological disorders 3An 'all natural' diet? There's no such thing 2An 'all natural' diet? There's no such thing 3BGI releases a complete de novo E. coli O104 genome and details of their detection kit 2
(Date:1/22/2015)... Selexis SA, a serial innovation company ... (RCBs) used for drug discovery to commercial manufacturing, announced ... Next-Generation Sequencing (NGS) data packages. The NGS ... by ensuring the integrity of the gene, validation of ...
(Date:1/22/2015)... , Jan. 22. 2015  Varian Medical Systems (NYSE: ... been honored for its commitment to sustainability with inclusion on ... is the highest ranked healthcare equipment company among the Corporate ... the World Economic Forum at Davos, Switzerland ...
(Date:12/24/2014)... , Dec. 24, 2014  United Therapeutics Corporation (NASDAQ: ... MDT ) has submitted a pre-market approval ... for the use of Medtronic,s SynchroMed ® II ... for use with United Therapeutics, Remodulin ® (treprostinil) ...
(Date:12/24/2014)... “Preparative & Process Chromatography Market ... (Columns, Solvents, Buffers, Valves, Guages, Seals), Accessories, Services, ... Forecasts to 2019” provides a detailed overview of ... trends, and strategies impacting the preparative and process ...
Breaking Biology Technology:Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2Varian Honored Among World's 100 Most Sustainable Corporations 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4
... /PRNewswire-FirstCall/,-- Oridion Systems Ltd. (SIX Swiss Exchange: ... project findings will be presented at the,upcoming ... in,Anaheim, California. These studies confirm the clinical ... Microstream(R) capnography technology,and clearly show that capnography ...
... the Comprehensive Microbial Resource enable researchers to quickly and effectively use ... ... 10, 2008 -- OpenHelix today announced the availability of ... CMR is a public resource for the analysis of prokaryotes, ...
... Brent Sumerlin has earned a National Science Foundation ... faculty members who exemplify the role of teacher-scholars ... professor in the Dedman College Department of Chemisty, ... related nanotechnology research projects one with potential ...
Cached Biology Technology:Oridion Announces Significant Medical Research to be Presented at AARC Congress 2Oridion Announces Significant Medical Research to be Presented at AARC Congress 3New Online Tutorial for the Comprehensive Microbial Resource (CMR) 2SMU chemist wins NSF early career award 2
Our original highly-purified, robust Taq Polymerase which delivers consistently high yields and minimal background...
A formulation of our Biolase DNA Polymerase which contains a Red Loading Dye...
... (ELISA) test kits are qualitative one-step kits ... of drugs and/or their metabolites in forensic ... use only. It is recommended that all ... method such as GC/MS. The simple ...
... pending) is a protein based inhibitor of ... the most common and troublesome RNases including ... SUPERaseIn can be used in any application ... is ideal for in vitro transcription and ...
Biology Products: