"This study demonstrated for the first time that phloretin, a natural flavonoid, is a nontoxic inhibitor of enterohemorrhagic E. coli O157:H7 biofilms, but does not harm commensal E. coli K-12 biofilms," Lee writes. "Also, importantly, our results confirmed that phloretin shows anti-inflammatory properties in both the in vitro and in vivo inflammatory colitis models. The effect of phloretin was noticeably more pronounced than that of the conventional [inflammatory bowel disease] drug 5-aminosalicylic acid."
(J.-H. Lee, S.C. Regmi, J.-A. Kim, M.H. Cho, H. Yun, C.-S. Lee, and J. Lee, 2011. Apple flavonoid phloretin inhibits Escherichia coli O157:H7 biofilm formation and ameliorates colon inflammation in rats. Infect. Immun. 79:4819-4827.)
Cold Spots Contaminated in High Humidity Incubators
Microbes in human incubators, like those found in neonatal intensive care units, grow most robustly on cold spots when the relative humidity is at least 60 percent, according to a paper in the December 2011 issue of the journal Applied and Environmental Microbiology.
Two of the high humidity incubators tested in this study sustained contamination by Staphylococcus, "a reason for concern, since the vast majority of infections in preterm neonates are caused by [staphylococci]," according to the report. Additionally, the researchers observed "slightly increased numbers of Gram-negative bacteria at the cold sites of neonatal incubators with high humidity levels," noting that infections with such "are known to have the highest neonatal death rates."
In this study, Hermie J.M. Harmsen and colleagues of the University of Groningen, The Netherlands, sampled cold and warm spots from 12 incubators with a relative humidity of at least 60 percent, and a temperature of at least 34 degrees C., and 11 incubators with a relative humidity of le
|Contact: Jim Sliwa|
American Society for Microbiology