Navigation Links
Tips from the journals of the American Society for Microbiology
Date:11/16/2010

ce, 40-60 million years ago, was a time of rapid accumulation of exogenous and other elements into the genome, including multiple families of viruses, so-called "short interspersed elements" and pseudogenes. That's a curious phenomenon which merits investigating, says first author Vladimir A. Belyi.

(V.A. Belyi, A J. Levine, A. Skalka. 2010. Sequences from Ancestral Single-Stranded DNA Viruses in Vertebrate Genomes: the Parvoviridae and Circoviridae Are More than 40 to 50 Million Years Old. Journal of Virology; 84.23: 12458-12462.)


Cellular Protein Hobbles HIV-1

A cellular protein called BST-2 had already been known to interfere with the spread of human immunodeficiency virus type 1 (HIV-1), by inhibiting the release of its progeny particles from infected cells. Now a team from McGill University, Montreal, shows that in addition, each progeny virion's ability to cause infection is severely impaired.

"BST-2 may exert a more potent inhibition effect on HIV-1 transmission than previously thought," says coauthor Chen Liang. The research is published in the December Journal of Virology.

BST-2 appears to attenuate infectivity of progeny particles by interfering with their maturation. Normally, during synthesis of new virus particles, a protein called PR55Gag is cleaved into three major structural proteins of HIV. "This cleavage process transforms HIV-1 from an immature and non-infectious virion into a mature and infectious virion," says Chen. The protease inhibitors, drugs given to AIDS patients to contain the disease, block this step. Similarly, BST-2 seems to interfere with this step, because in the study, its presence was associated with accumulation of uncleaved Gag precursor and intermediate products. The mechanism of that interference has yet to be elucidated.

BST-2 (bone marrow stromal cell antigen-2), also known as tetherin, is a cellular protein which has been shown to rest
'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1 2 3 4 5 6

Related biology news :

1. Mycotoxin Research joins Springers life sciences journals program
2. Oxford Journals and the International Society for Computational Biology announce new partnership
3. Springer and Senckenberg society to collaborate on life sciences and geosciences journals
4. Highlights from the March editions of ESA journals
5. Three prominent Cell Press journals named among the 100 most influential journals in past 100 years
6. 3 prominent Cell Press journals named among the 100 most influential journals in past 100 years
7. Annals of the ESA selected as one of 100 most influential journals
8. Tips from the journals of the American Society for Microbiology
9. Tips from the Journals of the American Society for Microbiology
10. Tips from the Journals of the American Society for Microbiology
11. Tips from the Journals of the American Society for Microbiology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/8/2015)... , April 8, 2015  Infinisource, a ... and services, and Morpho, a leading supplier of ... to produce the market,s most advanced biometrically-enabled time ... iSolved NXG time clock is setting a bold, ... labor data for the small and mid-size employer. ...
(Date:4/2/2015)... 2015 At its 2015 ACMG Annual Clinical ... , the American College of Medical Genetics and Genomics ... its Board.  Members of the ACMG Board of Directors ... and advancing its policies and programs. ACMG is the ... "It,s an eventful time in medical genetics and genomics.  ...
(Date:4/1/2015)... Apr. 1, 2015  NXT-ID, Inc. (NASDAQ: NXTD ... focused on the growing mobile commerce market, announces the ... wallets is underway to early access pre-order customers. ... usage at retail outlets including Walmart, Target, AT&T, Dunkin, ... Wocket was accepted at all outlets and very easy ...
Breaking Biology News(10 mins):iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 5American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 6American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 7American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 8NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 4
... European Alps suggests that population declines to be observed ... effects of recent climate warming on mountain plants. A ... Department of Conservation Biology, Vegetation and Landscape Ecology of ... to predict migration of mountain plants which explicitly takes ...
... LSU,s Mark Batzer, along with research associate Jerilyn Walker ... modern-day orangutans are host to ancient jumping genes called Alu, ... was done in collaboration with the Zoological Society of San ... is featured in the new open access journal Mobile ...
... requirement for efficient mosquito mass-rearing technology has been one ... of the Sterile Insect Technique (SIT) against mosquitoes. ... next issue of the Journal of Medical Entomology ... Organization (FAO) and the International Atomic Energy Agency (IAEA) ...
Cached Biology News:European mountain plant population shows delayed response to climate change 2LSU research finds orangutans host ancient jumping genes 2
(Date:4/16/2015)... , April 16, 2015  Schulman Associates IRB, Inc., ... has signed a long-term lease on Laboratory Drive in ... Carolina . The location will house review board ... provide high quality reviews and customer service to clients. ... represented Schulman in the deal, while Capital Associates ...
(Date:4/16/2015)... Streetsboro, Ohio (PRWEB) April 16, 2015 ... Safety Index, overexertion involving an outside source was ... injuries. This includes injuries related to lifting, pushing, ... $15.1 billion in direct costs. The David Round ... Round is committed to working hard to develop ...
(Date:4/16/2015)... The Council for Agricultural Science and ... CAST Communication Award goes to Dr. Channapatna Prakash, ... Alabama. Award nominees must demonstrate an ability to ... use of television, radio, or other social media. ... specialist in the field of plant genetics and ...
(Date:4/16/2015)... , April 16, 2015 /PRNewswire/ - Portage Biotech Inc. ... Securities Exchange: PBT.U), is pleased to announce that the ... on April 25, 2015 to be held in ... Gregory Bailey and Mr. James Mellon , ... an update on the key programs at its subsidiaries, ...
Breaking Biology Technology:Schulman IRB to Open Office in Research Triangle Park, N.C. 2The David Round Company Helps Companies Meet OSHA Standards by Combining Safety, Ergonomics, and Productivity 2The 2015 Borlaug CAST Communication Award Goes to Channapatna Prakash 2Portage to Present at Master Investor 2015 in London, UK 2Portage to Present at Master Investor 2015 in London, UK 3Portage to Present at Master Investor 2015 in London, UK 4
... NeoStem, Inc. (NYSE Amex: NBS ), which is ... stem cells for future medical need, announced today it has ... Managing Partner of Bernstein & Pinchuk LLP, to serve as ... Mr. Bernstein co-founded Bernstein & Pinchuk LLP (B&P) in 1983, ...
... Experience Daily Pain From Rheumatoid Arthritis Despite Current ... Rheumatism Annual Congress of Rheumatology , , ... Rheumatoid Arthritis: Insights, Strategies & Expectations (RAISE) survey ... throughout Europe and Canada revealed a majority of ...
... LONDON, June 9 /PRNewswire/ -- The Healthcare ... despite difficult economic times, renewals of Web of ... have even added new content to their portfolio of ... largest citation database, providing researchers, administrators, faculty and students ...
Cached Biology Technology:NeoStem, Inc. Appoints Financial Expert with Broad International Experience to the Board of Directors and to Serve as Chairman of the Company's Audit Committee 2NeoStem, Inc. Appoints Financial Expert with Broad International Experience to the Board of Directors and to Serve as Chairman of the Company's Audit Committee 3New Survey Reveals That More Than Half of Rheumatoid Arthritis Patients in Europe and Canada Feel Their Disease Controls Their Lives 2New Survey Reveals That More Than Half of Rheumatoid Arthritis Patients in Europe and Canada Feel Their Disease Controls Their Lives 3New Survey Reveals That More Than Half of Rheumatoid Arthritis Patients in Europe and Canada Feel Their Disease Controls Their Lives 4New Survey Reveals That More Than Half of Rheumatoid Arthritis Patients in Europe and Canada Feel Their Disease Controls Their Lives 5New Survey Reveals That More Than Half of Rheumatoid Arthritis Patients in Europe and Canada Feel Their Disease Controls Their Lives 6Web of Science(R) Renewals Remain Strong Despite Tough Economic Climate 2
Chicken Anti-Human Stomatin-like 2 (STOML2 Polyclonal AntibodyNew Applications: ELISA, Western Blot...
Anti-Chicken IgY, (IgG) F(ab')2 Fragment Specific....
... Polyclonal Antibody to Asb-2 (Ankyrin repeat ... was raised against synthetic peptides containing amino ... protein. Human spleen lysate (Imgenex Catalog No. ... control. It should cross react with mouse ...
Monoclonal Anti-Gα o purified immunoglobulin buffered aqueous solution Solution in phosphate buffered saline pH 7.4, containing 0.08% sodium azide. partially purified bovine brain Gα O ...
Biology Products: