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Tips from the Journals of the American Society for Microbiology
Date:9/9/2009

the study brain tissue samples were collected from cattle orally infected with BSE at varying time points following postinfection and monitored for changes in gene expression. Researchers found that 114 genes were differentially regulated over the course of infection, many of which encode proteins involved in functions such as immune response, stress response and cell adhesion. The largest number of differentially regulated genes was detected at 21 months postinfection indicating many pathogenic processes in the animal brain prior to detection of BSE in the central nervous system.

"Gene expression profiling in the BSE time course study revealed a broad correlation between the expression of genes and the progression of BSE," say the researchers. "Evidence is presented to suggest that it is possible to predict the infectious status of animals using the expression profiles from this study."

(Y. Tang, W. Xiang, S.A.C. Hawkins, H.A. Kretzschmar, O. Windl. 2009. Transcriptional changes in the brains of cattle orally infected with the bovine spongiform encephalopathy agent precede detection of infectivity. Journal of Virology, 83. 18: 9464-9473.)


Common Viral Infection in Infants May Persist Long-term in the Central Nervous System

A new study suggests that coxsackievirus, a significant human pathogen that commonly infects the central nervous system of newborns, may persist in the body as a low-level, long-term infection causing ongoing inflammatory lesions. This discovery disputes previous beliefs that while acute, coxsackievirus is also self-limiting. The researchers report their findings in the September 2009 issue of the Journal of Virology.

Coxsackievirus is a commonly occurring childhood infection that afflicts the central nervous system. It is often diagnosed in newborns and can lead to complications such as meningitis, encephalitis, and death. Prior research indicates that infecti
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Contact: Carrie Slijepcevic
cslijepcevic@asmusa.org
American Society for Microbiology
Source:Eurekalert

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