Navigation Links
Tips from the Journals of the American Society for Microbiology
Date:9/9/2009

New Antibiotic Shows Promise in Fighting Malaria

A new study suggests that tigecycline, the first member of a new class of antibiotics, shows significant antimalarial activity on its own and may also be effective against multi drug-resistant malaria when administered in combination with traditional antimalarial drugs. The researchers from the Medical University of Vienna, Austria; Malaria Research Initiative Bandarban, Bangladesh; and the International Center for Diarrheal Disease Research, Dhaka, Bangladesh report their findings in the September 2009 issue of the journal Antimicrobial Agents and Chemotherapy.

Increasing resistance of Plasmodium falciparum to existing drugs has resulted in the search for new antimalarial therapies. Tigecycline belongs to a novel class of antibiotics called glycylcyclines which exhibit unique and novel methods of action against bacteria and are specifically designed to overcome two mechanisms of tetracycline resistance. Clinical studies of tigecycline have shown it is easy to administer and is generally well tolerated with a twice-daily dosing regimen.

In the study blood samples were collected from male and nonpregnant female patients in Bangladesh infected by P. falciparum. Specifically excluded from the study were pregnant or breastfeeding women and patients who had received malaria drug therapy up to 30 days prior. When tested with 66 isolates tigecycline showed one the highest activities of all antibiotics against P. falciparum. Additionally, tigecycline was up to 6 times more active against P. falciparum than doxycycline, however, when tested in conjunction with doxycycline, a significant activity correlation was noted. Finally, further testing of tigecycline confirmed earlier studies indicating that tigecycline may induce a delayed-death response and also that it has a relatively long half-life making it simpler to administer than tetracycline and doxycycline.

"
'/>"/>

Contact: Carrie Slijepcevic
cslijepcevic@asmusa.org
American Society for Microbiology
Source:Eurekalert

Page: 1 2 3 4 5

Related biology news :

1. Tips from the Journals of the American Society for Microbiology
2. ESA celebrates 100 years of insect science journals
3. Springer and the New York Botanical Garden Press join forces to publish botanical journals
4. 200 journals join in theme issues on poverty and human development
5. Tips from the Journals of the American Society for Microbiology
6. Humana Press journals now available on SpringerLink
7. Tips from the Journals of the American Society for Microbiology
8. Tips from the Journals of the American Society for Microbiology
9. Mycotoxin Research joins Springers life sciences journals program
10. Oxford Journals and the International Society for Computational Biology announce new partnership
11. Springer and Senckenberg society to collaborate on life sciences and geosciences journals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... , Saturday to Wednesday, Oct. 18-22, 2014 , ... W. Harbor Drive, San Diego, CA 92101 , ... and other presentations of the latest research in ... plenary session featuring high-scoring abstracts on rare genetic ... various cancers, and treatment for sun sensitivity (Saturday, ...
(Date:8/21/2014)... A team of researchers at Louisiana Tech ... using affordable, consumer-grade 3D printers and materials ... contain antibacterial and chemotherapeutic compounds for targeted ... doctoral students and research faculty from Louisiana ... collaborated to create filament extruders that can ...
(Date:8/21/2014)... pancreatitis involves the pancreas digesting itself resulting in severe ... the UK around 20,000 patients are diagnosed with the ... cure and treatment is restricted to intravenous fluid and ... Faculty of Life Sciences, who led the research, said ... from gall stones and excessive alcohol intake combined with ...
Breaking Biology News(10 mins):American Society of Human Genetics 2014 Annual Meeting 2Louisiana Tech University researchers use 3D printers to create custom medical implants 2Louisiana Tech University researchers use 3D printers to create custom medical implants 3Insulin offers new hope for the treatment of acute pancreatitis 2
... bacterium or virus starts rummaging through the contents of a ... host,s DNA strands, it can alter the host,s biological course. ... particular sequences of DNA, to bend, kink and twist the ... any part of a DNA strand, but these seemingly random ...
... , HOUSTON -- (Aug. 30, 2012) -- The threads of ... biology are beginning to unravel, thanks to a new investigation ... Texas MD Anderson Cancer Center. In new research published ... Oleg Igoshin and MD Anderson,s Christian Ray offer a possible ...
... Bacteria in hyenas, scent glands may be the ... the current issue of Scientific Reports , show ... and the distinct microbial communities that reside in their ... and Michigan State University postdoctoral researcher. "A critical ...
Cached Biology News:Biophysicists unravel secrets of genetic switch 2Biophysicists unravel secrets of genetic switch 3Rice, MD Anderson scientists probe mystery of operon evolution 2Rice, MD Anderson scientists probe mystery of operon evolution 3Rice, MD Anderson scientists probe mystery of operon evolution 4Microbes help hyenas communicate via scent 2
(Date:8/21/2014)... YORK , Aug. 21, 2014 ... congratulates Immune Pharmaceuticals Inc., a biotechnology company, on ... Market.  Immune previously traded on OTCQX®, the best ... by OTC Markets Group. Logo - ... Pharmaceuticals on the successful execution of its growth ...
(Date:8/21/2014)... Aug. 21, 2014  Four-dimensional (4-D) printing develops ... on external stimuli such as changes in temperature. ... disruptive effect in multiple industries.  In the near ... by printing objects ranging from human organs to ... Logo - http://photos.prnewswire.com/prnh/20140820/138289 ...
(Date:8/21/2014)... Bulgaria (PRWEB) August 21, 2014 ... released today by Ontotext . Now the ... semantic analysis of structured and unstructured data is available ... the cost of enterprise technology. Organizations that do not ... for data management can use S4 since there is ...
(Date:8/21/2014)... Boston, MA (PRWEB) August 21, 2014 ... collaboration company, has been recognized as one of ... 500 | 5000 magazine for the 2nd consecutive ... on its 33rd annual Inc. 500|5000, an exclusive ... list represents the most comprehensive look at the ...
Breaking Biology Technology:OTC Markets Group Congratulates Immune Pharmaceuticals on NASDAQ Listing 2Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 2Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 3Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 4Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 2Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 3Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 4SoundConnect Returns on Inc. 5000 List of Fastest Growing Companies 2SoundConnect Returns on Inc. 5000 List of Fastest Growing Companies 3
... , , ... , , , Duplications and ... different methods are used for detecting such rearrangements,most based on either ... accurate, but very labour intensive and expensive,while quantitative PCR methods are ...
... , ... , , , Slab ... the separated bands,of an unknown sample to a known,standard (size ... estimated. The Agilent,2100 bioanalyzer is an instrument,which utilizes LabChip,technology to ...
... , , ... , , , , Gene expression ... for analyzing cellular behavior in a micro,scale and is used in ... of RNA from specific cell,populations out of their surrounding tissue environment. ...
Cached Biology Technology:Rapid detection of genomic,duplications and deletions using,the Agilent 2100 bioanalyzer 2Rapid detection of genomic,duplications and deletions using,the Agilent 2100 bioanalyzer 3Rapid detection of genomic,duplications and deletions using,the Agilent 2100 bioanalyzer 4Rapid detection of genomic,duplications and deletions using,the Agilent 2100 bioanalyzer 5High resolution DNA analysis with the,DNA 500 and DNA 1000 LabChip kits 2High resolution DNA analysis with the,DNA 500 and DNA 1000 LabChip kits 3High resolution DNA analysis with the,DNA 500 and DNA 1000 LabChip kits 4High resolution DNA analysis with the,DNA 500 and DNA 1000 LabChip kits 5Quality assurance of RNA derived from,laser microdissected tissue samples,obtained by the PALM MicroBeam System,using the RNA 6000 Pico LabChip kit. 2Quality assurance of RNA derived from,laser microdissected tissue samples,obtained by the PALM MicroBeam System,using the RNA 6000 Pico LabChip kit. 3Quality assurance of RNA derived from,laser microdissected tissue samples,obtained by the PALM MicroBeam System,using the RNA 6000 Pico LabChip kit. 4Quality assurance of RNA derived from,laser microdissected tissue samples,obtained by the PALM MicroBeam System,using the RNA 6000 Pico LabChip kit. 5Quality assurance of RNA derived from,laser microdissected tissue samples,obtained by the PALM MicroBeam System,using the RNA 6000 Pico LabChip kit. 6Quality assurance of RNA derived from,laser microdissected tissue samples,obtained by the PALM MicroBeam System,using the RNA 6000 Pico LabChip kit. 7Quality assurance of RNA derived from,laser microdissected tissue samples,obtained by the PALM MicroBeam System,using the RNA 6000 Pico LabChip kit. 8
SH3 Proteins II Sampler Kit 10g each...
... reagent for Virus isolation ... unique water insoluble Elastomeric ... and chaotropes; Engineered to ... viruses while preserving infectivity; ...
Golgi Sampler Kit 10g each...
Caveolin Sampler Kit 10g each...
Biology Products: