Navigation Links
Tips from the Journals of the American Society for Microbiology
Date:9/9/2009

New Antibiotic Shows Promise in Fighting Malaria

A new study suggests that tigecycline, the first member of a new class of antibiotics, shows significant antimalarial activity on its own and may also be effective against multi drug-resistant malaria when administered in combination with traditional antimalarial drugs. The researchers from the Medical University of Vienna, Austria; Malaria Research Initiative Bandarban, Bangladesh; and the International Center for Diarrheal Disease Research, Dhaka, Bangladesh report their findings in the September 2009 issue of the journal Antimicrobial Agents and Chemotherapy.

Increasing resistance of Plasmodium falciparum to existing drugs has resulted in the search for new antimalarial therapies. Tigecycline belongs to a novel class of antibiotics called glycylcyclines which exhibit unique and novel methods of action against bacteria and are specifically designed to overcome two mechanisms of tetracycline resistance. Clinical studies of tigecycline have shown it is easy to administer and is generally well tolerated with a twice-daily dosing regimen.

In the study blood samples were collected from male and nonpregnant female patients in Bangladesh infected by P. falciparum. Specifically excluded from the study were pregnant or breastfeeding women and patients who had received malaria drug therapy up to 30 days prior. When tested with 66 isolates tigecycline showed one the highest activities of all antibiotics against P. falciparum. Additionally, tigecycline was up to 6 times more active against P. falciparum than doxycycline, however, when tested in conjunction with doxycycline, a significant activity correlation was noted. Finally, further testing of tigecycline confirmed earlier studies indicating that tigecycline may induce a delayed-death response and also that it has a relatively long half-life making it simpler to administer than tetracycline and doxycycline.

"
'/>"/>

Contact: Carrie Slijepcevic
cslijepcevic@asmusa.org
American Society for Microbiology
Source:Eurekalert

1

GOOD

Page: 1 2 3 4 5

Related biology news :

1. Tips from the Journals of the American Society for Microbiology
2. ESA celebrates 100 years of insect science journals
3. Springer and the New York Botanical Garden Press join forces to publish botanical journals
4. 200 journals join in theme issues on poverty and human development
5. Tips from the Journals of the American Society for Microbiology
6. Humana Press journals now available on SpringerLink
7. Tips from the Journals of the American Society for Microbiology
8. Tips from the Journals of the American Society for Microbiology
9. Mycotoxin Research joins Springers life sciences journals program
10. Oxford Journals and the International Society for Computational Biology announce new partnership
11. Springer and Senckenberg society to collaborate on life sciences and geosciences journals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/18/2010)... can live for twenty years, fertilizing millions of eggs ... activity. , Danish researchers who have studied ants ... 1992 discovered that in both ant and bee species ... fluid favors the survival of its own sperm over ... stored, leafcutter ant queens neutralize male-male sperm competition with ...
(Date:3/18/2010)... available in Spanish . , Feeding ... as part of their regular diet makes them ... a study by Agricultural Research Service (ARS) scientists ... and overall behavioral activity among young female pigs ... acquired through diet, is the precursor for the ...
(Date:3/18/2010)... Biotech, Inc., ( www.genwaybio.com ) the US-based diagnostic company ... is expanding this cancer testing program internationally. An ... YouTM Cancer Assessment in Greece starting in April. ... as well. GenWay currently offers this test in ... Sergey Sikora, Vice President of Business Development, said, "The ...
Breaking Biology News(10 mins):Females shut down male-male sperm competition in leafcutter ants 2Tryptophan-enriched diet reduces pig aggression 2Moravia Worldwide Names George Krawczyk as Sales Director for Ireland and UK 61905 1Moravia Worldwide Names George Krawczyk as Sales Director for Ireland and UK 61905 2Barbara Fentress Designer of the Denver International Airport and Convention Center Offers Her Private Mansion at Absolute Auction 61902 1Barbara Fentress Designer of the Denver International Airport and Convention Center Offers Her Private Mansion at Absolute Auction 61902 2Ophthalmic Equipment Distributor Latham 26amp 3B Phillips SE Division Unveils Website 61899 1Ophthalmic Equipment Distributor Latham 26amp 3B Phillips SE Division Unveils Website 61899 2Ophthalmic Equipment Distributor Latham 26amp 3B Phillips SE Division Unveils Website 61899 3
... which glows under ultraviolet light have shown that up ... cleaned. Their findings, published in BioMed Centrals journal, BMC ... bacteria Clostridium difficile (C. difficile) linger in the loo ... Michelle Alfa and a team of scientists from Manitoba, ...
... N.J., May 9 BIO-key International, Inc.,(OTC Bulletin Board: BKYI) ... Thursday, May 15, 2008 before the market opens.,In conjunction with ... broadcast live over the Internet on Thursday, May 15, 2008 ... International, Inc. First Quarter 2008 Earnings Conference ...
... researchers have invented a method for turning simple data ... fish biodiversity, allowing better prediction of the effects of ... like dams. , The mathematics behind the new method ... wide range of other questions, from the transmission of ...
Other Biology News:UV lotion lights the way to cleaner facilities 2BIO-key(R) Announces First Quarter 2008 Earnings Release and Conference Call Schedule 2Rainfall and river networks prove accurate predictors of fish biodiversity 2Rainfall and river networks prove accurate predictors of fish biodiversity 3Rainfall and river networks prove accurate predictors of fish biodiversity 4
(Date:3/16/2010)... Stock Exchange Symbol: MS , ... , , ... ... EDMONTON , March 16 ... ...
(Date:3/16/2010)... PharmAthene, Inc. (Amex: PIP ) a biodefense company developing medical countermeasures against biological and chemical threats, announced today that its financial results ... ... , ... ... ...
(Date:3/16/2010)... March 16 The Gynecologic Cancer Foundation (GCF) and the Claudia ... as the first recipient of the $50,000 GCF/Claudia Cohen Prize for Outstanding ... (SGO) 41st Annual Meeting on Women,s Cancer, meeting in San Francisco ... ... ...
(Date:3/16/2010)... (LSE: SHP,NASDAQ; SHPGY), announces that it has received a Paragraph IV Notice ... New Drug Application ("ANDA") for a generic version of Shire,s 1,mg, 2mg, ... ... ... , ...
Breaking Biology Technology:BioMS Medical Announces 2009 Year End Results 2BioMS Medical Announces 2009 Year End Results 3BioMS Medical Announces 2009 Year End Results 4BioMS Medical Announces 2009 Year End Results 5BioMS Medical Announces 2009 Year End Results 6BioMS Medical Announces 2009 Year End Results 7BioMS Medical Announces 2009 Year End Results 8BioMS Medical Announces 2009 Year End Results 9BioMS Medical Announces 2009 Year End Results 10PharmAthene to Host Year-End 2009 Earnings Conference Call and Webcast on Tuesday, March 23, 2010 2PharmAthene to Host Year-End 2009 Earnings Conference Call and Webcast on Tuesday, March 23, 2010 3Paul Goodfellow, PhD, Awarded First GCF/Claudia Cohen Prize for Outstanding Gynecologic Cancer Researcher 2Paul Goodfellow, PhD, Awarded First GCF/Claudia Cohen Prize for Outstanding Gynecologic Cancer Researcher 3Paul Goodfellow, PhD, Awarded First GCF/Claudia Cohen Prize for Outstanding Gynecologic Cancer Researcher 4Paul Goodfellow, PhD, Awarded First GCF/Claudia Cohen Prize for Outstanding Gynecologic Cancer Researcher 5Shire Receives INTUNIV (TM) Paragraph IV Notice Letter From Teva Pharmaceuticals 2Shire Receives INTUNIV (TM) Paragraph IV Notice Letter From Teva Pharmaceuticals 3Shire Receives INTUNIV (TM) Paragraph IV Notice Letter From Teva Pharmaceuticals 4
... artificial disc and dynamic stabilization,nonfusion segments skyrocketed, according to Millennium ... ... Mass., April 24 Millennium Research Group,s,(MRG) US Spine Marketrack(TM) ... technologies. Rising patient and surgeon,awareness and new product releases starting ...
... Aida,Pharmaceuticals, Inc. (OTC Bulletin Board: AIDA) today announced ... interest in Jiangsu,Institute of Microbiology Co., Ltd. ("JSIM"), ... People,s Republic of China. JSIM,has several drugs currently ... development pipeline. This acquisition is expected to add,several ...
... SimBioSys, a leader in the field of,rational drug ... architecture to dramatically speed up the process of ... speed by which,scientists can perform virtual screening calculations., ... software on the,IBM(R) BladeCenter(R) QS2 based on the ...
Other Biology Technology:Adoption of Spinal Nonfusion Technologies Doubled in One Year 2Aida Pharmaceuticals, Inc. Announces Completion of Research Institute Acquisition 2SimBioSys Utilizes Revolutionary Hardware Technology to Open New Frontiers in Molecular Modeling 2
Recombinant Equine IL-4, CF...
Recombinant Rat Leptin, CF...
VACUGENE PUMP 110V, 1 EA. Category: Nucleid Acid Detection Systems....
delta-like 1 homolog (Drosophila)...
Biology Products: