Navigation Links
Tips from the Journals of the American Society for Microbiology
Date:6/19/2012

vis Agbandje-McKenna of the University of Florida, Gainesville and her colleagues have determined the precise structure of AAV9, work she says "will help us to understand which parts of the capsid we can alter or modify to make safer, more efficient vectors, and which regions should not be modified as we try to engineer capsids to treat specific diseases." The capsid is the shell that protects the viral nucleic acid.

The researchers applied X-ray crystallography, the technique that was used to determine DNA's structure nearly 60 years ago, as well as a complementary, and much newer technique called cryo-electron microscopy and image reconstruction, to determining AAV9's structure. That work revealed the precise position in space of every atom of the AAV9 capsid. They then compared that structure to other adeno-associated viruses for which structures have been determined, and identified which regions are conserved, and which vary, in comparison to AAV9. They then annotated these regions with respect to function: different parts of the capsid are involved in different functions such as receptor attachment, determining the efficiency of transduction in specific tissues, and antibody recognition.

"Our goal is to use 3D information to inform the design of gene delivery vectors that will have improved efficacy with respect to tissue targeted delivery of therapies, and reduced host immune antibody response recognition," says Agbandje-McKenna. "The information that we have obtained is guiding further research in our group as well as groups elsewhere who are trying to understand the functions of the capsid, in an effort to improve gene delivery via AAV." She notes that AAV9 is especially important in these areas because of its ability to cross the blood brain barrier, adding that this makes it particularly useful for treating brain diseases, "for which current therapies are quite limited."

(M.A. DeMattia, H.-J. Nam, K. Van Vliet, M. Agbandje-McKe
'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1 2 3 4 5 6 7

Related biology news :

1. Top young Latin-American scientists named Pew Biomedical Fellows
2. UMass Medical School scientist named 2012 Pew Latin-American Fellow in the Biomedical Sciences
3. CU-Boulder-led team finds microbes in extreme environment on South American volcanoes
4. The American Society for Microbiology honors Anthony R. Richardson
5. The American Society for Microbiology honors Susan Sharp
6. The American Society for Microbiology honors Geoffrey L. Smith
7. The American Society for Microbiology honors I. Kaye Wachsmuth
8. The American Society for Microbiology honors Bess B. Ward
9. The American Society for Microbiology honors Anthony R. Richardson
10. The American Society for Microbiology honors Susan Sharp
11. The American Society for Microbiology honors Geoffrey L. Smith
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/11/2014)... , Dec. 09, 2014 Research and ... ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has ... in India 2015-2019" report to their offering. ... this market is the adoption of multimodal biometric ... characteristic of an individual for verification and identification ...
(Date:12/10/2014)... N.C. , Dec. 9, 2014  Wake Forest Baptist ... education building for its School of Medicine. Funding for ... larger capital campaign that will be publicly launched next ... be located in the former 60 series R.J. Reynolds ... Innovation Quarter. Construction will begin immediately with plans to ...
(Date:12/5/2014)... , Dec. 4, 2014  Tute Genomics, a ... $2.3 million in Series A1 funding led by UK-based ... also participated in the investment round. "We ... healthcare community adopts next-generation sequencing and seeks new approaches ... Reid Robison , MD MBA, and CEO of ...
Breaking Biology News(10 mins):Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 3
... ENTU ), a world leader in securing digital identities and information, ... December 31, 2008.Fourth-Quarter 2008, , ... of 7% over Q4 2007; total revenues were impacted by a ... 5%, adjusting for currency , ...
... why some allergic reactions progress quickly and may even ... February 2009 issue of the Journal of Leukocyte ... of the answer. In the report, scientists from Queen,s ... Dublin show for the first time that eotaxin, a ...
... Times are tough for wildlife living at the frontier ... are reportedly encamped in a national park and wildlife preserve ... have settled in an adjoining Ugandan park. And yet, ... more than 900 individuals of the emblematic African lion, according ...
Cached Biology News:Entrust Announces Financial Results for Fourth-Quarter and Fiscal 2008 2Entrust Announces Financial Results for Fourth-Quarter and Fiscal 2008 3Entrust Announces Financial Results for Fourth-Quarter and Fiscal 2008 4Entrust Announces Financial Results for Fourth-Quarter and Fiscal 2008 5Entrust Announces Financial Results for Fourth-Quarter and Fiscal 2008 6Entrust Announces Financial Results for Fourth-Quarter and Fiscal 2008 7Entrust Announces Financial Results for Fourth-Quarter and Fiscal 2008 8Entrust Announces Financial Results for Fourth-Quarter and Fiscal 2008 9Entrust Announces Financial Results for Fourth-Quarter and Fiscal 2008 10Entrust Announces Financial Results for Fourth-Quarter and Fiscal 2008 11Entrust Announces Financial Results for Fourth-Quarter and Fiscal 2008 12Entrust Announces Financial Results for Fourth-Quarter and Fiscal 2008 13Entrust Announces Financial Results for Fourth-Quarter and Fiscal 2008 14Entrust Announces Financial Results for Fourth-Quarter and Fiscal 2008 15Entrust Announces Financial Results for Fourth-Quarter and Fiscal 2008 16Entrust Announces Financial Results for Fourth-Quarter and Fiscal 2008 17Entrust Announces Financial Results for Fourth-Quarter and Fiscal 2008 18Entrust Announces Financial Results for Fourth-Quarter and Fiscal 2008 19Entrust Announces Financial Results for Fourth-Quarter and Fiscal 2008 20Entrust Announces Financial Results for Fourth-Quarter and Fiscal 2008 21New discovery may lead to new class of allergy drugs 2Research uncovers surprising lion stronghold in war-torn central Africa 2Research uncovers surprising lion stronghold in war-torn central Africa 3
(Date:12/24/2014)... , Dec. 23, 2014 Sigma-Aldrich ... that the waiting period under the Hart-Scott-Rodino Antitrust ... acquisition expired on December 22, 2014, thereby completing ... requirement for the acquisition of the Company by ... antitrust clearance satisfies another condition to closing the ...
(Date:12/22/2014)... PA & Brussels (PRWEB) December 22, 2014 ... (CfPIE), the global leader of technical training across ... Society for Clinical Data Management (SCDM) to provide ... and certification programs —providing access to the more ... partnership extends SCDM members with 10% off when registering ...
(Date:12/22/2014)... , Dec. 22, 2014  Alternative Energy & ... it has signed a letter of intent to ... developed and patented a nanotechnology-based development platform used ... that enable rapid on-site collection and testing to ... health issues in an immediate, non-invasive and cost-effective ...
(Date:12/22/2014)... 2014 The American Journal ... original research, reviews and editorials addressing developments and ... today published a provocative article exploring the role ... and potential treatment of prostate cancer. , ... proposes the possibility that there could be a ...
Breaking Biology Technology:Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 2Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 3CfPIE Announces Partnership with the Society for Clinical Data Management 2CfPIE Announces Partnership with the Society for Clinical Data Management 3ALNE Announces Intention To Acquire BioTechPharma 2Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 2Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 3Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 4
... Calif., June 16 The Ensign,Group, Inc. (Nasdaq: ... of,skilled nursing, rehabilitative care services and assisted living,companies, announced ... cash dividend of $0.04 per share of Ensign common ... of record as of June 30, 2008.,Ensign has been ...
... and SAN DIEGO, June 16 3M ... today that 3M has,discontinued the companies, collaboration ... (HCAIs)., The companies, which are exploring ... this area, said the collaboration was,discontinued due ...
... AAHC Report Recommends Alternatives to Protect Privacy and ... rule of the,Health Insurance Portability and Accountability Act ... of biomedical research and the search for,treatments that ... of Academic Health Centers (AAHC). HIPAA Creating Barriers ...
Cached Biology Technology:The Ensign Group Declares Quarterly Dividend 23M Discontinues Collaboration with Gen-Probe to Develop Molecular Tests for Healthcare-Associated Infections 23M Discontinues Collaboration with Gen-Probe to Develop Molecular Tests for Healthcare-Associated Infections 3HIPAA Privacy Rule Impedes Biomedical Research 2
Cell Culture Flask, 75 cm, treated polystyrene...
Cell Culture Flask, 75 cm, nontreated polystyrene...
... In virtually every research laboratory, the ... of information accurately, inexpensively and in real ... compact lab analysis system includes the Luminex ... It utilizes xMAP technology which enables you ...
... Analysis of large numbers of samples may ... gradient system, which requires minimum operator attention. ... by PowerStream software and interface CE 4900. ... software operates in Windows XP and Windows 98 ...
Biology Products: