The research originated in the search for prebiotic fiber sources, says Lindberg. "In this context, chicory was a good candidate as both the root and the above-ground biomass, the forage, can be eaten by animals and humans. We knew that there are many members of the chicory family that we regularly eat in salad."
"Prebiotic dietary effects can be used to minimize the occurrence of enteric disease, thereby reducing the need to use antimicrobials," says Lindberg. "This will improve animal productivity and welfare, and will also minimize the occurrence of contaminated products that can pose threats in the human food chain." Lindberg also says that he would expect a similar response to these dietary changes in humans.
(H. Liu, E. Ivarsson, J. Dicksved, T. Lundh, and J.E. Lindberg, 2012. Inclusion of chicory (Cichorium intybus L.) in pigs' diets affects the intestinal microenvironment and the gut microbiota. Appl. Environ. Microbiol. 78:4102-4109.)
Download the journal article at http://bit.ly/asm061912c
Researchers Determine 3D Structure of Adeno-Associated Virus 9: Aim to Boost Gene Therapy
A team of researchers led by the University of Florida, Gainesville, has determined the precise structure of a virus that has promise as a delivery vehicle for gene therapy. The research appears in the June 2012 issue of the Journal of Virology.
Adeno-associated viruses are benign in humans, and are highly promising in gene therapy as delivery devices to place healthy genes into the genome, in order to compensate for malfunctioning genes. These viruses come in 12 different serotypes (sets of antigens). Adeno-associated virus 9 (AAV9) is currently under development as a delivery vehicle for treating neurodegenerative diseases, such as spinal muscle atrophy, amyotrophic lateral sclerosis, and Parkinson's disease.
|Contact: Jim Sliwa|
American Society for Microbiology