Navigation Links
Tips from the Journals of the American Society for Microbiology
Date:12/21/2007

Herpesvirus May Play Role in Central Nervous System Diseases

Scientists have discovered evidence suggesting a herpesvirus may be responsible for some cases of meningitis and encephalitis. Researchers from the New York State Department of Public Health, Albany and SUNY, Albany report their findings in the December 2007 issue of the Journal of Clinical Microbiology.

Human herpesvirus 6 (HHV-6) is one of the most prevalent in humans. There are two variants of HHV-6, HHV-6A and HHV-6B which is attributed to a common childhood disease characterized by a high fever and rash. Studies indicate that by age 3 the majority of children have been infected by HHV-6, after which the virus persists in the salivary glands into adulthood. The virus may remain dormant or reactivate in immunocompetent or immunocompromised individuals.

Over a span of four years, researchers collected specimens from patients hospitalized with symptoms of encephalitis and meningitis, and tested them for the presence of HHV-6. The majority of the specimens were taken from cerebrospinal fluid and some of the symptoms exhibited by the patients include fever, altered mental status, and abnormal CSF profile, as well as seizures in those ages 3 and under. Results showed that 26 specimens from 24 patients were positive for HHV-6, of which 20 were identified as the HHV-6B strain. Forty-two percent of the patients were age 3 or under, possibly indicating primary infection, while the remaining patients ranging from 4 to 81 years old were probably experiencing viral reactivation.

The detection of HHV-6 in specimens from patients diagnosed with encephalitis or meningitis, in the absence of a positive PCR result for other agents, strongly suggests a role for HHV-6 in the pathogenesis of these central system diseases, say the researchers.

(N.P. Tavakoli, S. Nattanmai, R. Hull, H. Fusco, L. Dzigua, H. Wang, M. Dupuis. 2007. Detection and typing of human herpesvirus 6 by molecular methods in specimens from patients diagnosed with encephalitis or meningitis. Journal of Clinical Microbiology, 45. 12: 3972-3978.)


Novel Virus Identified in Endangered Species May Represent Evolution of Two Major Virus Families

The near extinction of the western barred bandicoot has led to the identification of a novel virus exhibiting characteristics of two ancient virus families. The researchers from Murdoch University, Perth, Western Australia, and the University of Leuven, Belgium report their findings in the December 2007 issue of the Journal of Virology.

The western barred bandicoot (WWB), an Australian marsupial once commonly found across western and southern Australia, is now endangered throughout parts of the country and already extinct on the mainland. While promoting conservation efforts, researchers discovered a debilitating disease affecting the species causing full body lesions.

Papillomaviruses (PVs) and polyomaviruses (PyVs) are known to infect human, mammalian, and avian species. They were previously considered subunits of the Papovaviridae family, however they are currently recognized as two separate virus families due to significantly different genome sizes and organizations. In the study researchers analyzed skin swabs taken from the lesions of infected WWBs and identified a novel virus exhibiting properties of both the Papillomaviridae and Polyomaviridae family. They have designated this new prototype the bandicoot papillomatosis carcinomatosis virus type 1 (BPCV1).

BPCV1 may represent the first member of a novel virus family, descended from a common ancestor of the papillomaviruses and polyomaviruses recognized today, say the researchers. The discovery of the virus could have implications for the current taxonomic classification of Papillomaviridae and Polyomaviridae and can provide further insight into the evolution of these ancient virus families.

L. Woolford, A. Rector, M.V. Ranst, A. Ducki, M.D. Bennett, P.K. Nicholls, K.S. Warren, R.A. Swan, G.E. Wilcox, A.J. OHara. 2007. A novel virus detected in papillomavirus and carcinomas of the endangered western barred bandicoot (Perameles bougainville) exhibits genomic features of both the Papillomaviridae and Polyomaviridae. Journal of Virology, 81. 24: 13280-13290.)


'/>"/>
Contact: Carrie Patterson
cpatterson@asmusa.org
American Society for Microbiology
Source:Eurekalert

Related biology news :

1. Tips from the Journals of the American Society for Microbiology
2. ESA celebrates 100 years of insect science journals
3. Springer and the New York Botanical Garden Press join forces to publish botanical journals
4. 200 journals join in theme issues on poverty and human development
5. American Chemical Societys Weekly PressPac -- Aug. 8, 2007
6. Understanding hypertension in African Americans proves elusive
7. American Chemical Societys Weekly PressPac -- Aug. 15, 2007
8. American College of Medical Genetics responds to new FDA labeling decision for warfarin
9. American Chemical Societys Weekly Press Pac
10. Highlights from the September 2007 Journal of the American Dietetic Association
11. American Chemical Societys Weekly Presspac -- Aug. 29, 2007
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/15/2016)... April 15, 2016  A new partnership announced ... accurate underwriting decisions in a fraction of the ... priced and high-value life insurance policies to consumers ... With Force Diagnostics, rapid testing (A1C, Cotinine ... readings (blood pressure, weight, pulse, BMI, and activity ...
(Date:3/31/2016)... RATON, Florida , March 31, 2016 ... LEGX ) ("LegacyXChange" or the "Company") ... for potential users of its soon to be launched ... video ( https://www.youtube.com/channel/UCyTLBzmZogV1y2D6bDkBX5g ) will also provide ... the use of DNA technology to an industry that ...
(Date:3/22/2016)... 2016 According to ... for Consumer Industry by Type (Image, Motion, Pressure, ... & IT, Entertainment, Home Appliances, & Wearable ... 2022", published by MarketsandMarkets, the market for ... USD 26.76 Billion by 2022, at a ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... Mosio, ... second eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering with experienced clinical ... eBook by providing practical tips, tools, and strategies for clinical researchers. , “The ...
(Date:6/23/2016)... June 23, 2016 Houston Methodist Willowbrook ... Cy-Fair Sports Association to serve as their official ... Houston Methodist Willowbrook will provide sponsorship support, athletic ... with association coaches, volunteers, athletes and families. ... Cy-Fair Sports Association and to bring Houston Methodist ...
(Date:6/23/2016)... ... , ... Supplyframe, the Industry Network for electronics hardware design ... Located in Pasadena, Calif., the Design Lab’s mission is to bring together inventors ... and brought to market. , The Design Lab is Supplyframe’s physical representation of ...
(Date:6/23/2016)... 2016 Andrew D ... http://doi.org/10.17925/OHR.2016.12.01.22 Published recently in ... from touchONCOLOGY, Andrew D Zelenetz , discusses ... care is placing an increasing burden on healthcare ... therapies. With the patents on many biologics expiring, ...
Breaking Biology Technology: