whose normal function is to protect the body against parasitic infections. They are also commonly associated with asthma and allergies. Numerous prior studies have noted the presence of Toll-like receptors (TLRs) on the surfaces of eosinophils indicating that they may play a part in recognizing and killing viruses and bacteria. In the study researchers found that isolated mouse eosinophils possessed antibacterial properties against Pseudomonas aeruginosa
in vitro. In vivo, transgenic mice demonstrating high levels of eosinophils, showed improved clearance of P. aeruginosa
, whereas bacterial clearance was impaired in mice with a congenital eosinophil deficiency suggesting an eosinophil specific effect.
"We provide evidence that mouse eosinophils and eosinphil granules play a beneficial but poorly defined role in innate immune responses to bacterial infections," say the researchers. "Moreover, the data suggest that the administration of eosinophil-derived products may represent a viable adjuvant therapy for septic or bacteremic patients in the intensive care unit."
(S.N. Linch, A.M. Kelly, E.T. Danielson, R. Pero, J.J. Lee, J.A. Gold. 2009. Mouse eosinophils possess potent antibacterial properties in vivo. Infection and Immunity, 77. 11: 4976-4982.)
Tooth-Binding Micelles Containing Antimicrobials May Provide Long-Term Cavity Protection
A new study suggests that tooth-binding micelles (or particles) may provide long-term cavity protection by adhering to tooth surfaces and gradually releasing encapsulated antimicrobials. Formulation of a mouthwash-based delivery system is anticipated, ultimately simplifying application and increasing at-home patient compliance. The researchers from the University of Nebraska Medical Center, Omaha and the University of Florida, Gainesville report their findings in the November 2009 issue of the journal Antimicrobial Agents and Chemotherapy.
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