Navigation Links
Tips from the Journals of the American Society for Microbiology
Date:8/20/2007

oped an animal model for oral poliovirus infection. They report their findings in the August 2007 issue of the Journal of Virology.

Poliovirus causes acute disease in the central nervous system in humans often resulting in paralysis. Due to its reemerging presence in developing countries researchers are reexamining the viruses ability to spread among humans through oral ingestion and develop new preventative therapies accordingly.

Due to the human digestive tracts low sensitivity to the poliovirus, no previous rodent model tracking oral infection has been developed. In the study mice carrying the human poliovirus receptor gene and lacking the interferon receptor gene (IFNAR) were sensitive to an oral challenge of the poliovirus. Nine days following the challenge the mice had died and the virus was detected in their small intestines and digestive tracts. Mice expressing the interferon receptor gene were found to be much less sensitive to virus.

These results suggest that IFNAR plays an important role in determining permissivity in the alimentary tract as well as the generation of virus-specific immune responses to poliovirus via the oral route, say the researchers. Thus, hPVR-Tg/IfnarKO are considered to be the first oral infection model for poliovirus.

(S. Ohka, H. Igarashi, N. Nagata, M. Sakai, S. Koike, T. Nochi, H. Kiyono, A. Nomoto. 2007. Establishment of a poliovirus oral infection system in human poliovirus receptor-expressing transgenic mice that are deficient in alpha/beta interferon receptor. Journal of Virology, 81. 15: 7902-7912).


'/>"/>

Contact: Carrie Patterson
cpatterson@asmusa.org
American Society for Microbiology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims
2. Open Access journals get impressive impact factors
3. Funding and bureaucracy, not access to journals, are chief obstacles to scientific productivity
4. Impressive new Impact Factors for BioMed Centrals open-access journals
5. First North American Encapsulated Islet Transplant without Long-term Immune Suppression into a Patient with Type 1 Diabetes
6. Health costs soar as 60 million Americans classed as obese
7. Discovery of an American salamander where it shouldnt be: Korea
8. DNA traces evolution of extinct sabertooths and the American cheetah-like cat
9. North & South American researchers find architectural abnormalities in T. cruzi ribosome
10. T-rays: New imaging technology spotlighted by American Chemical Society
11. New peptide antibiotic isolated from American oyster
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... a suite of perilous threats in today,s ocean. ... climate change, fragile coral ecosystems are disappearing at ... some species of corals surrounding the island of ... in their tropical environment: coral guard-crabs. New research ... Marine Station scientist Seabird McKeon and the museum,s ...
(Date:9/29/2014)... species of gut bacteria called Clostridium ramosum , coupled ... The work is published this week in mBio , ... , A research team from the German Institute of ... gut bacteria including C. ramosum gained weight when ... C. ramosum were less obese even when consuming a ...
(Date:9/29/2014)... 1970 and 2010 populations of mammals, birds, reptiles, ... percent, says the 2014 Living Planet Report released ... loss occurs disproportionately in low-income countriesand correlates with ... In addition to the precipitous decline in wildlife ... signs about the overall health of the planet. ...
Breaking Biology News(10 mins):Smithsonian scientists discover coral's best defender against an army of sea stars 2Gut bacteria promote obesity in mice 2Half of global wildlife lost, says new WWF report 2
... chemotherapy for the treatment of skin cancer is one ... researchers successfully synthesized a natural substance that shows exceptional ... U of A chemistry professor Dennis Hall said after ... produced the substance called Palmerolide A. "The potency ...
... DigitalPersona, Inc., a leader in fingerprint identity ... a leading supplier of point-of-sale (POS) software for ... NextGen POS and Classic POS solutions. WAND,s quick-service ... cashier accountability and deter unauthorized manager overrides. ...
... the blink of a geologic eye global temperatures were ... come by. Today, the largest island in the world is covered ... hot spot for climate scientists. Why? Because tiny bubbles ... about global warming: how fast and how much will ice ...
Cached Biology News:WAND Point-of-Sale Solutions Integrate U.are.U(R) Fingerprint Biometrics From DigitalPersona for Quick-Service Restaurants 2WAND Point-of-Sale Solutions Integrate U.are.U(R) Fingerprint Biometrics From DigitalPersona for Quick-Service Restaurants 3As Greenland melts 2
(Date:9/30/2014)... (PRWEB) September 30, 2014 ... solutions for drug discovery and related life ... consortium has chosen Genedata Selector as its ... (NGS) data. FUNGITECT is a European consortium ... fungal diseases via individualized anti-fungal drug therapies. ...
(Date:9/30/2014)... , Sept. 30, 2014  KemPharm, Inc., ... discovery and development of proprietary new molecular entity ... Patent and Trademark Office (USPTO) issued U.S. Patent ... entitled, "Benzoic Acid, Benzoic Acid Derivatives and Heteroaryl ... Making and Use Thereof." The patent, ...
(Date:9/30/2014)... MAR, Calif. , Sept. 30, 2014 ... for women,s health announces its receipt of a patent ... FemmyCycle menstrual cup has also received FDA clearance in ... Canada, and the CE in Europe. This patent is related ... conjunction with this issuance, the company is releasing FemmyCycle ...
(Date:9/30/2014)... The overall research objective was to ... and use. Most researchers outsource NGS technologies; however, ... within the next 12 months. Data accuracy and ... sequencing instruments. Disease-related research is the dominant use ... to surge, with half of the respondents planning ...
Breaking Biology Technology:FUNGITECT Consortium Adopts Genedata Selector as Data Analysis Platform for Anti-fungal R 2FUNGITECT Consortium Adopts Genedata Selector as Data Analysis Platform for Anti-fungal R 3KemPharm, Inc. Receives Patent from the USPTO for Novel Prodrug of Hydromorphone, KP511 2The FemmyCycle 2Global Next-generation Sequencing Trends 2
... GeneGo, Inc., the leading,systems biology tools company, announced ... Center of Excellence. MD Anderson researchers will have,institution-wide ... advanced support. MD Anderson specializes in cancer treatment ... clinical trials programs.,MetaCore will be used throughout many ...
... and VANCOUVER, Sept. 2 /PRNewswire-FirstCall/ - OncoGenex,Pharmaceuticals, ... the "Company") has,announced today that it has ... rights to develop and commercialize TOCOSOL(R),Paclitaxel. Under ... entitled to,receive royalty payments from future TOCOSOL ...
... EDISON, N.J., Sept. 1 PSKW, LLC, a ... the pharmaceutical,industry, announced today that it has significantly ... last year in the Supreme Court of the ... McKesson Specialty Arizona Inc.,("McKesson"), a wholly-owned subsidiary of ...
Cached Biology Technology:MD Anderson Becomes a GeneGo Center of Excellence Using MetaCore for Oncology Research 2OncoGenex Pharmaceuticals announces out-license of TOCOSOL Paclitaxel to Eagle Pharmaceuticals 2OncoGenex Pharmaceuticals announces out-license of TOCOSOL Paclitaxel to Eagle Pharmaceuticals 3PSKW Expands Its Lawsuit Against McKesson to Seek Assignment of McKesson's Patent Application 2
...
N,N'-Methylene-bis-acrylamide, Ultra Pure...
... Serum; U.S. sourced, ideal for ... quality; Low hemoglobin; Endotoxin: < ... of US origin; U.S. sourced, ... an uncompromising quality. Low hemoglobin ...
NEWBORN CALF SERUM AND PLASMA...
Biology Products: