Navigation Links
Tips from the American Journal of Pathology
Date:5/21/2009

the brain and the spinal cord. A certain type of immune cell, Th17 T cells, plays a pathogenic role in MS and other autoimmune diseases.

Using a mouse model of MS, Klenmann et al found that AM80, a synthetic molecule related to vitamin A, inhibited Th17 T cell function without generating general immunosuppression. AM80 treatment was effective in inhibiting early symptoms in the MS mouse model, even if administered after disease initiation, but it did not prevent chronic symptoms.

Drs. Yamamura, Oki, and colleagues "conclude that treatment with the synthetic retinoid AM80 is a considerable intervention strategy for the acute phase of Th17-mediated autoimmune diseases such as MS."

Klemann C, Raveney BJE, Klemann AK, Ozawa T, von Hrsten S, Shudo K, Oki S, Yamamura T: Synthetic retinoid AM80 inhibits Th17 cells and ameliorates EAE. Am J Pathol 2009, 174: 2234-2245


Repair After Eye Injury

Drs. Sandrine Joly, Charlotte Rem, and colleagues have discovered that both resident and circulating cells remove damaged cells after eye injury. These results are presented in the June 2009 issue of the American Journal of Pathology.

The eyes, like the brain, are an immune-privileged site; the so called blood-retinal barrier limits access of immune cells to the eyes. After eye damage, however, immune cells remove damaged cells.

To locate the source of the immune cells that respond to retinal injury, Joly et al used a mouse model of light-induced photodamage. They found that both resident and circulating (from the bone marrow) immune cells were involved in removal of dead retinal cells. The circulating cells entered the eye without damaging the blood-retinal barrier, and both circulating and resident immune cells entered the blood stream after removing the dead cells.

Joly et al suggest that this process may "enable an immunization against retinal proteins. Specific retinal pr
'/>"/>

Contact: Angela Colmone
acolmone@asip.org
301-634-7953
American Journal of Pathology
Source:Eurekalert

Page: 1 2 3 4 5

Related biology news :

1. American Chemical Societys Weekly PressPac -- Aug. 8, 2007
2. Understanding hypertension in African Americans proves elusive
3. Tips from the Journals of the American Society for Microbiology
4. American Chemical Societys Weekly PressPac -- Aug. 15, 2007
5. American College of Medical Genetics responds to new FDA labeling decision for warfarin
6. American Chemical Societys Weekly Press Pac
7. Highlights from the September 2007 Journal of the American Dietetic Association
8. American Chemical Societys Weekly Presspac -- Aug. 29, 2007
9. Report: African, Asian, Latin American farm animals face extinction
10. American Chemical Society calls green chemistry bill a smart step
11. Challenges remain in reintroducing American chestnut
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... KONG , Sept. 30, 2014 Winners of ... Economist Events, Innovation Summit scheduled to take place at the JW ... the summit, the award winners will share their experiences and the ... who have made a proven innovation over the past decade, will ... the night before the summit. It will be the first ...
(Date:9/29/2014)... Washington, DC Monday, September 29: Between 1970 ... and fish around the globe dropped 52 percent, ... by World Wildlife Fund (WWF). This biodiversity loss ... increasing resource use of high-income countries. , In ... the report,s data point to other warning signs ...
(Date:9/29/2014)... of Texas at Arlington research team says recently identified ... their lab could open doors for homeland security and ... in the Oct. 1 issue of Optics Letters ... co-authors describe a new method to fabricate transparent nanoscintillators ... until a transparent ceramic is formed. A scintillator ...
Breaking Biology News(10 mins):Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 2Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 3Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 4Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 5Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 6Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 7Half of global wildlife lost, says new WWF report 2UT Arlington researchers develop new transparent nanoscintillators for radiation detection 2UT Arlington researchers develop new transparent nanoscintillators for radiation detection 3
... scientists have begun to harness DNA,s powerful molecular machinery ... natural ability of pairs of DNA molecules to assemble ... the California Institute of Technology,* could provide a means ... and drug delivery systems, from the bottom up. ...
... . Sperm have only one aim: to find ... emitting attractants. Calcium ions determine the beating pattern of the sperm ... the Max Planck Institute for the Physics of Complex Systems in ... centre in Bonn, an institute of the Max Planck Society, have ...
... British Columbia is arguably the most important fossil deposit ... Cambrian "Explosion," the rapid flowering of complex life from ... comprised of shells, teeth and bones, the Burgess Shale ... delicate structuresof animals belonging to Earth,s earliest complex ecosystems ...
Cached Biology News:The shape of things to come: NIST probes the promise of nanomanufacturing using DNA origami 2Sperm can count 2Mechanism for Burgess Shale-type preservation 2
(Date:9/30/2014)... Lyme Research Alliance (LRA), the nation’s ... universities, today announced the awarding of seven grants worth ... cure for Lyme and other tick-borne diseases. , ... its history—over 20 grant proposals—a 100 percent increase from ... receive so many solid applications from talented scientists this ...
(Date:9/30/2014)... 2014 Rainbow Scientific, Inc. (RSI), ... recently opened an online store to add customer ... lines developed and manufactured by Biological Industries, Inc. ... Biological Industries’ Nutristem® serum-free, xeno-free reagents for human ... cell (hESC) culture. , The online store ...
(Date:9/30/2014)... (PRWEB) September 30, 2014 UFP ... and specialty packaging has recently introduced a custom ... Suspension Pack . The new insulated shipper solves ... chain distribution process. UFP Technologies’ BioShell is a ... bags during storage, handling and shipping. The insulated ...
(Date:9/30/2014)... Back in the 1970’s, many companies calculated ... employee, which included space for circulation and file storage. ... partner at Nidea Corporate Real Estate / ITRA Global ... year 2000, however, 250 square feet per employee became ... down to 175 to 225 square feet, and over the ...
Breaking Biology Technology:Lyme Research Alliance Awards Nearly $600,000 in New Grants 2Lyme Research Alliance Awards Nearly $600,000 in New Grants 3Lyme Research Alliance Awards Nearly $600,000 in New Grants 4Rainbow Scientific, Inc. opens online store for state-of-the-art stem cell culture and cytogenetic reagents 2UFP Technologies Introduces Insulated Shipping Container For Bulk Drug Transportation 2UFP Technologies Introduces Insulated Shipping Container For Bulk Drug Transportation 3ITRA Global Reports on How Companies Are Squeezing More Employees into Less Office Space 2ITRA Global Reports on How Companies Are Squeezing More Employees into Less Office Space 3