Navigation Links
Tips from the American Journal of Pathology
Date:5/21/2009

Stromal Caveolin-1 Predicts Breast Cancer Prognosis

Two articles in the June 2009 issue of the American Journal of Pathology demonstrate the role of stromal caveolin-1 expression as a prognostic marker for breast cancer progression. These articles are highlighted by an accompanying Commentary.

Caveolin-1, a protein that functions in endocytosis and signal transduction, plays a major role in breast cancer tumorigenesis. However, although calveolin-1 expression has been extensively studied in epithelial cells in breast cancer patients, the value of epithelial caveolin-1 as a prognostic marker has been limited.

Witkiewicz et al and Sloan et al therefore examined caveolin-1 expression in the stromal microenvironment of human breast cancer. Stromal expression of caveolin-1 correlated with reduced levels of metastasis, and caveolin-1 was not expressed in stroma of patients with poor clinical outcome. In addition, tumor onset in mice was accelerated in the absence of stromal caveolin-1. Caveolin-1 may therefore function as a tumor suppressor in the stromal microenvironment and serve as a new prognostic marker for breast cancer progression.

Dr. Mina Bissell, who is not associated with these studies, suggests that "for now, the two studies presented in this issue of the AJP provide additional validation that the microenvironment is an important and potentially powerful source of clinical information to predict patient outcome, and demonstrate specifically that stromal Cav-1 may be a valuable clinical marker. Determining whether stromal Cav-1 functions to directly suppress tumor growth, and uncovering the factors which regulate its expression, may also reveal novel therapeutic avenues."

Witkiewicz AK, Dasgupta A, Sotgia F, Mercier I, Pestell RG, Sabel M, Kleer CG, Brody JR, Lisanti MP: An Absence of Stromal Caveolin-1 Expression Predicts Early Tumor Recurrence and Poor Clinical Outcome in Human Breast Canc
'/>"/>

Contact: Angela Colmone
acolmone@asip.org
301-634-7953
American Journal of Pathology
Source:Eurekalert

Page: 1 2 3 4 5

Related biology news :

1. American Chemical Societys Weekly PressPac -- Aug. 8, 2007
2. Understanding hypertension in African Americans proves elusive
3. Tips from the Journals of the American Society for Microbiology
4. American Chemical Societys Weekly PressPac -- Aug. 15, 2007
5. American College of Medical Genetics responds to new FDA labeling decision for warfarin
6. American Chemical Societys Weekly Press Pac
7. Highlights from the September 2007 Journal of the American Dietetic Association
8. American Chemical Societys Weekly Presspac -- Aug. 29, 2007
9. Report: African, Asian, Latin American farm animals face extinction
10. American Chemical Society calls green chemistry bill a smart step
11. Challenges remain in reintroducing American chestnut
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... Athens, Ga. The support of peer groups ... effective breastfeeding programs, according to recent University of ... mothers in the Athens-Clarke County area determined that ... the outcomes of mothers of infants. , "Mothers ... be successful at breastfeeding," said study co-author Alex ...
(Date:8/28/2014)... for delivering compounds that could positively impact ... may be possible, thanks to researchers in ... semi-soft vaginal suppository made from the seaweed-derived ... antiviral drug Tenofovir provides a woman-initiated, drug-delivery ... of sexually transmitted infections during unprotected heterosexual ...
(Date:8/28/2014)... measuring and imaging how quickly blood flows in the ... drug abuse affects the brain, which may aid in ... better treatment options for recovering drug addicts. The new ... Brook University in New York, USA and the U.S. ... Optical Society,s (OSA) open-access journal Biomedical Optics ...
Breaking Biology News(10 mins):Breastfeeding study shows need for effective peer counseling programs 2Sensory-tested drug-delivery vehicle could limit spread of HIV, AIDS 2Sensory-tested drug-delivery vehicle could limit spread of HIV, AIDS 3This is your brain's blood vessels on drugs 2This is your brain's blood vessels on drugs 3
... could help ease health and environmental concerns about the ... for changing the behavior of nanoparticles in municipal sewage ... Their study will be published online November 12 in ... Helen Jarvie from the UK Centre for Ecology ...
... a world leader of research in molecular biology and ... of Technology, has been named winner of the American ... of Biological Chemistry Lectureship. Sharp will ... RNAs," at the 2010 annual meeting at 6 p.m. ...
... for the 2009 United Nations Climate Change Conference in ... Advancement of Science (AAAS) will open a new exhibit ... A companion display shows what some school children are ... of climate change effects will be on display Wednesday, ...
Cached Biology News:Behavior modification could ease concerns about nanoparticles 2Nobel laureate claims the 2010 Herbert Tabor Lectureship 2AAAS exhibit featuring photographs of climate change opens Nov. 18 2AAAS exhibit featuring photographs of climate change opens Nov. 18 3
(Date:8/28/2014)...   SunTrust Robinson Humphrey (STRH) today ... its equity research team in biotechnology and oilfield ... equity research demonstrates our commitment to providing our ... their investment decision making," said Biff Woodruff ... to make significant investments in differentiated content at ...
(Date:8/28/2014)... new work by a Florida State University research team ... take your temperature, emit white light, and convert photon ... looks like a butterfly. , Biwu Ma, associate professor ... the FAMU-FSU College of Engineering, created the molecule in ... to discover that his creation has many other unique ...
(Date:8/28/2014)... August 28, 2014 Earlier this month, ... in partnership with the U.S. Air Force on ... The results indicated that this type of fuel made ... and will be important to America’s Eco friendly future. ... has a mandate to become independent of foreign oil ...
(Date:8/28/2014)... NY (PRWEB) August 28, 2014 Whitehouse ... its long term partnership with PTI Inspection Systems ... clients with state of the art leak testing method ... the art instruments currently available. As part of this ... High Voltage Leak Detection Instrument developed and ...
Breaking Biology Technology:SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 2SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 3Novel 'butterfly' molecule could build new sensors, photoenergy conversion devices 2Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 2Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 3Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 4Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 5Whitehouse Labs Renews Partnership with PTI Inspection Systems 2Whitehouse Labs Renews Partnership with PTI Inspection Systems 3
... A NASA-developed innovative process is making waves in ... new companies in the process. A new company ... Goddard Space Flight Center,s unique single-walled carbon nanotube ... low-cost SWCNTs available commercially. , Potential markets ...
... Institute (TCI), a Los,Angeles-based DNA and genomics research ... new office in the heart of Boston,s legal ... effects of,chemical and toxic exposures on human health ... Reach Consulting, TCI now offers a,range of business, ...
... Oriental,Bioengineering, Inc. (NYSE: AOB ), a leading manufacturer ... today,announced that the Company will attend the Credit Suisse ... in Shenzhen, China as well as,the 3rd Semi-Annual Investor ... Co. on September 11, 2007 in Beijing, China. ...
Cached Biology Technology:NASA technology forms the basis for a new nanotechnology company 2Revolutionary Genomics Research Group Opens Boston Office; Provides DNA Evidence in Workers Comp Cases 2American Oriental Bioengineering Announces Participation in September Investor Conferences 2
Designed for use with any of the Agencourt kits in tube format....
... is a fluorescent counterstain which ... color. The bright blue fluorescence ... fluorochromes such as rhodamine, Cy3, ... can be used for fluorescent ...
... 20-HETE is a cytochrome P450 (CYP450) metabolite ... the renal and cerebral vasculature. In rat ... mediates pressure-induced autoregulatory vasoconstriction. 20-HETE is excreted ... of free 20-HETE (20-40 pg/ml in human ...
... APAgene kits are designed to rapidly and ... our patented APA Technology. APAgene provides hassle-free, ... price. All necessary ingredients are provided in ... be used for gap filling, localized cloning ...
Biology Products: