Navigation Links
Tips from the American Journal of Pathology
Date:3/24/2009

gut. These bacteria contribute to digestion, but also may cause disease. Some bacteria, such as Escheria coli (E. coli) or Citrobacter rodentium (C. rodentium), can breach the intestinal epithelial barrier, entering the blood and causing systemic infection.

Lymphostatin, a toxin produced by gram negative bacteria including E. coli and C. rodentium, has been associated with bacterial virulence. To determine if lymphostatin affects epithelial barrier integrity, Babbin et al generated two strains of C. rodentium, CrGIM21 and CrPrM5, with different mutations in lymphostatin. Whereas wild-type C. rodentium disrupted epithelial barrier function, CrGIM21 and CrPrM5 had reduced effects on two aspects of epithelial cell function. These data suggest that lymphostatin may be a strong target candidate for treatment of enteric gram negative bacteria.

Dr. Klapporth and colleagues postulate that "therapeutic interventions in form of specific immunoglobulins directed against lymphostatin and its enzymatic activities might provide an attractive alternative to antibiotics in treating intestinal injury and preventing extraintestinal manifestations of Gram negative infection."

Babbin BA, Sasaki M, Gerner-Schmidt KW, Nusrat A, Klapproth J-M A: The bacterial virulence factor lymphostatin compromises intestinal epithelial barrier function by modulating Rho GTPases. Am J Pathol 2009, 174: 1347-1357


Mouse Model of Human Psoriasis

Researchers led by Nicole Ward at Case Western Reserve University, Cleveland have developed a new mouse model to study human psoriasis. These findings are presented in the April 2009 issue of The American Journal of Pathology.

Psoriasis is a chronic inflammatory disease that causes red scaly patches to appear on the skin. It is characterized by excessive skin production, formation of new blood vessels, and the presence
'/>"/>

Contact: Angela Colmone
acolmone@asip.org
301-634-7953
American Journal of Pathology
Source:Eurekalert

Page: 1 2 3 4 5

Related biology news :

1. The American Association for Cancer Research congratulates Margaret Hamburg, M.D.
2. American Chemical Societys weekly PressPac -- March 11, 2009
3. American carnivores evolved to avoid each other, new study suggests
4. News from the March 2009 Journal of the American Dietetic Association
5. Many middle-aged and older Americans not getting adequate nutrition
6. American Institute of Physics announces awards for best science writing
7. Honest crabs, power to the hungry, nice mice and clever meerkats: News from the American Naturalist
8. Carnegies Doug Koshland elected Fellow of the American Academy of Microbiology
9. African-Americans aware and accepting, but often do not receive, the HPV vaccine
10. Statement by the Egg Nutrition Center and American Egg Board on Diabetes Care study on egg consumption
11. News from the February 2009 Journal of the American Dietetic Association
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... Dec. 22, 2014  The 2014 Holiday Season may be ... Market Intelligence reports that the long anticipated floodgates for ... intensifying demand for smart phones, tablets, and wearable mobile ... of 2.5 billion users with nearly 4.8 billion biometric ...
(Date:12/19/2014)... LAS VEGAS , Dec. 18, 2014   LaunchKey ... built for the post-password and Internet of Things era, ... seed funding. The venture round was led by Metamorphic ... Capital, Rimrock Venture Partners, VegasTechFund, and others.  LaunchKey has ...
(Date:12/17/2014)... N.C. , Dec. 16, 2014 Valencell, a ... its PerformTek biometric technology to industry leaders such as ... accurate, clinically validated, biometric wearable products. These products will ... in Las Vegas . ...
Breaking Biology News(10 mins):First Season of Holiday Shopping with Mobile Biometric Payments Wraps Up With a Present for Biometrics Industry: A Rosy Forecast for More Than 2 Billion Users of 4.8 Billion Mobile Biometric Devices by 2020 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2
... a major role in a NASA mission, which they believe ... surface of a comet. , NASA's Deep Impact spacecraft will ... when a metre-long projectile will crash into the comet and ... plume of gas and dust. , UK astronomers involved in ...
... Society of Conservation Biology annual meetings, in Brasília, Brazil, ... Pesquisa Ambiental da Amazonia (IPAM) will hold an international ... resources in the Amazon Basin. , This region has ... the principle industries driving deforestation (cattle ranching and soybean ...
... at U.S. ports, a public enemy has infiltrated the nation's ... a Cornell University expert, the adult female alien is the ... United States. , The discovery of a single specimen of ... across the nation because the invasive insect species has devastated ...
Cached Biology News:NASA probe could reveal comet life, scientists claim 2Alien woodwasp, threat to US pine trees, found in N.Y. 2
(Date:1/22/2015)... GEA Niro Soavi the leader in high pressure ... 2000, which is ideal for new applications for processing ... . This compact laboratory homogenizer is the perfect solution ... additives and ingredients as well as for the ...
(Date:1/22/2015)... Protocol Networks brings independent technology consulting to the ... consultants, Protocol Networks has recently announced its expansion into ... his company has attracted several clients in The Constitution ... as others. With the success of these engagements, Rogers ...
(Date:1/22/2015)... 22, 2015 Dr. Greg Leyer of UAS ... Scripps Natural Supplements Pre-Conference seminar on probiotics in San Diego, ... annual continuing education conference for health care professionals. This year’s ... topic of probiotics in health. Dr. Leyer spoke about the ...
(Date:1/22/2015)... , 22 de enero de 2015  El Dr. ... su llamada a nominaciones para 2015. Este prestigioso premio ... o tiene el potencial para hacer, contribuciones destacadas para ... aceptarán hasta el 15 de marzo de 2015 a ...
Breaking Biology Technology:GEA Niro Soavi Announces the PandaPLUS 2000 Homogenizer for Processing New Applications for Nanoemulsions and Cell Disruption 2Protocol Networks Brings Independent Technology Consulting to the Constitution State 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4
... Purpose , ... the new Q TRAP LC/MS/MS system with Metabolite ID software for Phase ... increase your productivity and confidence in your results. , ... Current trends in drug development are placing more emphasis on ...
... Jason S. Wood, Varian, Inc. , ... Cytochrome P450s (CYPs) are heme-containing ... 1 . CYPs are part of the Phase I (oxidative) metabolism ... drug enabling either easy elimination of the drug or further conjugation ...
... , Z. Yang and S. ... Introduction , Amphetamine ... place, and by recreational users. Forensic, clinical, and doping laboratories are ... Urine samples are most common because large sample volumes can be ...
Cached Biology Technology:Identification of Phase I and Phase II Metabolites of Buspirone on the Q TRAP LC/MS/MS System 2Identification of Phase I and Phase II Metabolites of Buspirone on the Q TRAP LC/MS/MS System 3Identification of Phase I and Phase II Metabolites of Buspirone on the Q TRAP LC/MS/MS System 4Identification of Phase I and Phase II Metabolites of Buspirone on the Q TRAP LC/MS/MS System 5Simultaneous Detection of CYP3A4, CYP2D6 and CYP2C9 Metabolites with a Single, Sensitive, LC/MS/MS Method 2Simultaneous Detection of CYP3A4, CYP2D6 and CYP2C9 Metabolites with a Single, Sensitive, LC/MS/MS Method 3Rapid Screening of Amphetamine Drugs in Urine by Positive Ion Electrospray LC/MS/MS 2Rapid Screening of Amphetamine Drugs in Urine by Positive Ion Electrospray LC/MS/MS 3
Chicken polyclonal to YebU ( Abpromise for all tested applications). Antigen: Synthetic peptide, corresponding to amino acids 196-244 of E. coli YebU....
Rabbit polyclonal to Peptide E ( Abpromise for all tested applications)....
...
...
Biology Products: