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Tips from the American Journal of Pathology
Date:5/25/2010

] that in IPF fibroblasts, a lack of caveolin-1 expression in the plasma membrane reduces membrane-associated PTEN levels and activity. This confers IPF fibroblasts with a phenotype characterized by the ability to circumvent the proliferation-suppressive properties of polymerized type I collagen."

Xia H, Khalil W, Kahm J, Jessurun J, Kleidon J, Henke CA: Pathologic Caveolin-1 Regulation of PTEN in Idiopathic Pulmonary Fibrosis. Am J Pathol 2010, 176: 2626-2637


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Contact: Angela Colmone, Ph.D.
acolmone@asip.org
301-634-7953
American Journal of Pathology
Source:Eurekalert

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