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Tip sheet for journalists: Equol, soy, menopause and bone health research published in Journal of Nutrition
Date:7/8/2010

nonproducers (a decrease of 2.28 and 2.61, respectively.) Similarly the S-equol producers in the isoflavone group had significantly lower changes in their fat mass compared to nonproducers during the course of the study. The results suggest that using soy isoflavones to prevent bone loss and the accumulation of fat in women in early post-menopause may depend on an individual's equol-producing capacity.

"Dietary Equol and Bone Metabolism in Postmenopausal Japanese Women and Osteoporotic Mice," Yoshiko Ishimi, of the National Institute of Health and Nutrition in Tokyo, Japan

6. Equol May Help to Reduce Bone Loss

Estrogen produced in the body helps maintain dynamic bone with a high turnover rate. Menopause in women is associated with the body's stage when estrogen levels decrease. The reduction in production and circulating estrogen is associated with rapid bone loss. S-equol binds to estrogen receptor beta, in bone cells. A two-year randomized placebo-controlled trial that characterized postmenopausal women by their equol-producing status, showed that those who were equol producers had a 2.4 percent increase in the lumbar spine bone mineral density (BMD) compared with just 0.6 percent increase in the S-equol non-producers. Additional clinical studies have related women's equol producer status with changes in markers of bone turnover in response to treatments with soy isoflavones.

"Equol, via Dietary Sources or Intestinal Production, May Ameliorate Estrogen Deficiency-Induced Bone Loss," Connie M. Weaver and LeeCole L. Legette, of the Department of Foods and Nutrition at Purdue University in Indiana

7. Cultural influences on assessing Menopausal Hot Flashes

Hot flashes continue to be a troublesome problem for menopausal women the world over. After 50 years of research, Kronenberg reports that the specific cause and mechanism of hot flashes is still not understood, or how estrogen, the major pharmaceutical tre
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Contact: Stephen McCauley
smccauley@porternovelli.com
202-973-3615
Porter Novelli
Source:Eurekalert

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