The dietary supplement SE5-OH containing Natural S-equol, developed from soy, may be appropriate for women in menopause, based on results of recent clinical trials documenting its effectiveness and safety in relieving hot flushes and other symptoms of menopause. Nine articles on equol, soy, menopause, bone health and cancer research appear in a July 2010 supplement to the Journal of Nutrition and are summarized here.
About SE5-OH containing Natural S-equol
Soybeans contain a naturally occurring compound, the isoflavone called daidzein. Certain bacteria living within the human digestive tract can convert daidzein into S-equol [7-hydroxy-3-(4'-hydroxyphenyl)-chroman]. S-equol is thought to bind to the estrogen beta receptors, but further study is underway to confirm this hypothesis. Studies in Japan have documented an association in women between milder menopausal symptoms in those who naturally produce S-equol after eating soy compared to non-producers. The production of S-equol after soy consumption depends on the types of bacteria present in the large intestine and may be influenced by the amount of soy consumed. About 50 percent of Asians and 20 to 30 percent of North Americans and Europeans, who in general consume less soy than Asians, have the ability to produce equol. Pharmavite LLC, the makers of Nature Made vitamins and minerals and a subsidiary of Otsuka Pharmaceutical Co., Ltd., is conducting and sponsoring clinical trials that examine the use of SE5-OH containing Natural S-equol in supplement form for the management of menopausal symptoms.
1. Historical Overview of Soy and Isoflavone Research
Messina reviews the past two decades of soy and isoflavone research, noting that largely because of research evaluating the anticancer effects of soyfoods sponsored by the US National Cancer Institute in the 1990s, interest in the role of soy and isoflavones in disease prevention greatly incr
|Contact: Stephen McCauley|