Navigation Links
Tiny worm points to big promise
Date:1/6/2012

Two related studies from Northwestern University offer new strategies for tackling the challenges of preventing and treating diseases of protein folding, such as Alzheimer's, Parkinson's and Huntington's diseases, amyotrophic lateral sclerosis (ALS), cancer, cystic fibrosis and type 2 diabetes.

To do its job properly within the cell, a protein first must fold itself into the proper shape. If it doesn't, trouble can result. More than 300 diseases have at their root proteins that misfold, aggregate and eventually cause cellular dysfunction and death.

The new Northwestern research identifies new genes and pathways that prevent protein misfolding and toxic aggregation, keeping cells healthy, and also identifies small molecules with therapeutic potential that restore health to damaged cells, providing new targets for drug development.

The genetic screening study is published by the journal PLoS Genetics. The small molecule study is published by the journal Nature Chemical Biology.

"These discoveries are exciting because we have identified genes that keep us healthy and small molecules that keep us healthy," said Richard I. Morimoto, who led the research. "Future research should explain how these two important areas interact."

Morimoto is the Bill and Gayle Cook Professor of Biology in the department of molecular biosciences and the Rice Institute for Biomedical Research in Northwestern's Weinberg College of Arts and Sciences. He also is a scientific director of the Chicago Biomedical Consortium.

The genetic study reported in PLoS Genetics was conducted in the transparent roundworm C. elegans, which shares much of the same biology with humans. The small animal is a valued research tool because of this and also because its genome, or complete genetic sequence, is known.

In the work, Morimoto and his team tested all of the approximately 19,000 genes in C. elegans. They reduced e
'/>"/>

Contact: Megan Fellman
fellman@northwestern.edu
847-491-3115
Northwestern University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Deep biosphere research points to new methods for recovering petroleum
2. Duke study pinpoints potential green collar job growth in US
3. Leeds research points to new therapy for hepatitis C treatment
4. First-ever socioeconomic study on coral reefs points to challenges of coastal resource management
5. Engineering technology pinpoints earliest signs of animal life
6. Innerscope Research(R) Appoints Digital Leader, Andre Marquis, as Senior Vice President of Sales and Marketing
7. ID Analytics Appoints Chief Information Officer
8. ID Analytics Appoints Chief Information Officer
9. Innerscope Research(R) Appoints Digital Leader, Andre Marquis, as Senior Vice President of Sales and Marketing
10. Stem cell success points to way to regenerate parathyroid glands
11. UNC study pinpoints gene controlling number of brain cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/15/2014)... BETHESDA, Md. (April 15, 2014) The American ... 2014 award winners. All awards will be presented ... San Diego Marriott Hotel on Tuesday, April 29th at ... Biology (EB). , The 2014 award winners ... Jeffrey Laitman, PhD, of the Icahn School of ...
(Date:4/15/2014)... it has become clear that the genetic code ... addition to the well-known building blocks adenine, cytosine, ... important role. Scientists now assume that the newly ... layer of information that extends and complements the ... umlauts that extend the standard alphabet," explained Professor ...
(Date:4/14/2014)... 32-year study of subarctic forest moths in Finnish Lapland ... climate change on animals and plants because much of ... analyzed populations of 80 moth species and found that ... throughout the study period, from 1978 to 2009. During ... rose 3.5 degrees Fahrenheit, and winter precipitation increased as ...
Breaking Biology News(10 mins):American Association of Anatomists 2014 award winners 2German Research Foundation approves new priority program in the life sciences 2Moth study suggests hidden climate change impacts 2Moth study suggests hidden climate change impacts 3
... University of Granada (UGR) have compared the disaster caused by ... 11 years ago with the biggest species extinction known to ... scientists say that carrying out comparisons of this kind will ... mass extinctions. Until now, scientists used to study the ...
... , SUNNYVALE, Calif. and LIVERPOOL, England , ... intelligent video, announced that a major UK airport has completed the ... Vidient,s SmartCatch video analytics suite, while a second UK airport, ... , The SmartCatch system is a major component of the MFlow ...
... 1, 2010) -- Mapping DNase I hypersensitive sites ... regulatory elements such as promoters, enhancers, silencers, insulators, and ... provide access for transcription factors, are selectively digested by ... to then identify these hypersensitive sites. In the ...
Cached Biology News:Aznalcóllar disaster compared with Cretaceous mass extinction 2Vidient SmartCatch Protecting Exit Lanes at Major UK Airport 2Vidient SmartCatch Protecting Exit Lanes at Major UK Airport 3High-throughput analysis of gene regulation, DNA synthesis in Cold Spring Harbor Protocols 2
(Date:1/15/2014)... January 15, 2014 This webinar ... on nonclinical and clinical safety assessment in biosimilars. ... guide a path for biosimilar drug development, however ... of biosimilarity with regards to quality, safety and ... of biosimilar drug development and registration, development strategies ...
(Date:1/15/2014)... NC (PRWEB) January 15, 2014 ... an enhancement to its Online Web Portal for Life ... now have the ability to specify the subject matter ... nearly 50 life science sub-domains. This will help reduce ... and scientific fields, and decrease the likelihood of error. ...
(Date:1/14/2014)... Doylestown, PA (PRWEB) January 14, 2014 ... – 11 p.m. , Location: Warrington Country Club, 1360 ... Hepatitis B Foundation, the only national nonprofit organization solely ... improving the quality of life for those affected worldwide, ... 11 at Warrington Country Club in Warrington, Pa. ...
(Date:1/14/2014)... York, NY (PRWEB) January 14, 2014 ... initiated coverage of Alliqua, Inc. (OTCQB: ALQA). Alliqua ... and marketing proprietary products to serve the wound ... , In late 2012, Alliqua was restructured ... launched the company’s new strategy to become a ...
Breaking Biology Technology:Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2DTS Improves Efficiency for Life Science Document Translations 2Hepatitis B Foundation to Host Annual Crystal Ball Gala 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3
... January 29 Circassia Ltd, a specialty,biopharmaceutical ... today that it has successfully raised GBP11 ... funding. The investment,syndicate includes new investors Goldman ... investors, including Imperial Innovations and Lansdowne,Partners., ...
... Ill. Carbon nanotubes have a sound future ... the worlds first all-nanotube transistor radios to prove ... provide all of the active functionality in the ... implementation of carbon-nanotube materials into high-speed analog electronics ...
... 2008 -- NanoJapan, a unique, Rice University-based program ... Japan with a targeted undergraduate research internship in ... Education,s (IIE) prestigious Andrew Heiskell Award for Innovation ... years ago to promote and honor the most ...
Cached Biology Technology:Circassia Raises GBP11 Million ($21.8 Million) in Oversubscribed Second Round Funding 2New kind of transistor radios shows capability of nanotube technology 2Rice wins innovation award for international program 2
Quartz-Halogen, 100 W, High Intensity...
... 1;heading 2;Many mammalian ... experimental situations create ... transfection and other ... ViraPower Lentiviral Expression ...
The product contains 10 ml Dynabeads Epoxy (4.5 m). Supplied at 4 x 10 8 beads/ml...
...
Biology Products: