Navigation Links
Tiny worm points to big promise
Date:1/6/2012

Two related studies from Northwestern University offer new strategies for tackling the challenges of preventing and treating diseases of protein folding, such as Alzheimer's, Parkinson's and Huntington's diseases, amyotrophic lateral sclerosis (ALS), cancer, cystic fibrosis and type 2 diabetes.

To do its job properly within the cell, a protein first must fold itself into the proper shape. If it doesn't, trouble can result. More than 300 diseases have at their root proteins that misfold, aggregate and eventually cause cellular dysfunction and death.

The new Northwestern research identifies new genes and pathways that prevent protein misfolding and toxic aggregation, keeping cells healthy, and also identifies small molecules with therapeutic potential that restore health to damaged cells, providing new targets for drug development.

The genetic screening study is published by the journal PLoS Genetics. The small molecule study is published by the journal Nature Chemical Biology.

"These discoveries are exciting because we have identified genes that keep us healthy and small molecules that keep us healthy," said Richard I. Morimoto, who led the research. "Future research should explain how these two important areas interact."

Morimoto is the Bill and Gayle Cook Professor of Biology in the department of molecular biosciences and the Rice Institute for Biomedical Research in Northwestern's Weinberg College of Arts and Sciences. He also is a scientific director of the Chicago Biomedical Consortium.

The genetic study reported in PLoS Genetics was conducted in the transparent roundworm C. elegans, which shares much of the same biology with humans. The small animal is a valued research tool because of this and also because its genome, or complete genetic sequence, is known.

In the work, Morimoto and his team tested all of the approximately 19,000 genes in C. elegans. They reduced e
'/>"/>

Contact: Megan Fellman
fellman@northwestern.edu
847-491-3115
Northwestern University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Deep biosphere research points to new methods for recovering petroleum
2. Duke study pinpoints potential green collar job growth in US
3. Leeds research points to new therapy for hepatitis C treatment
4. First-ever socioeconomic study on coral reefs points to challenges of coastal resource management
5. Engineering technology pinpoints earliest signs of animal life
6. Innerscope Research(R) Appoints Digital Leader, Andre Marquis, as Senior Vice President of Sales and Marketing
7. ID Analytics Appoints Chief Information Officer
8. ID Analytics Appoints Chief Information Officer
9. Innerscope Research(R) Appoints Digital Leader, Andre Marquis, as Senior Vice President of Sales and Marketing
10. Stem cell success points to way to regenerate parathyroid glands
11. UNC study pinpoints gene controlling number of brain cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2015)... 23, 2015   Valencell, a leader ... of a recent study that illustrates its PerformTek ... during activity. In a study conducted at Valencell,s ... with the Apple Watch against a chest strap ... during activity. The study demonstrated that Valencell,s biometric ...
(Date:6/18/2015)... , June 18, 2015 NXT-ID, Inc. (NASDAQ: ... company focused on the growing mobile commerce market announces that ... featured segment on "Money on the Mark", scheduled to air ... June 20 th . The ... be from 7:00 to 8:00pm EST. NXT-ID, Inc.,s CEO ...
(Date:6/17/2015)... 2015  Synaptics Inc. (NASDAQ: SYNA ), ... that Xiaomi, one of the world,s largest mobile ... ® family of capacitive touchscreen solutions and ... for its latest smartphones, the Xiaomi Mi Note ... in-cell display solutions and DDICs in discrete display ...
Breaking Biology News(10 mins):Valencell Delivers Breakthrough Heart Rate Accuracy on the Wrist 2Valencell Delivers Breakthrough Heart Rate Accuracy on the Wrist 3NXT-ID, Inc.'s CEO Gino Pereira Talks About the Wocket Smart Wallet on WABC Radio, New York City, June 20th 2NXT-ID, Inc.'s CEO Gino Pereira Talks About the Wocket Smart Wallet on WABC Radio, New York City, June 20th 3Synaptics Touchscreen and Display Driver IC Solutions Power Xiaomi's Latest Flagship Smartphones 2Synaptics Touchscreen and Display Driver IC Solutions Power Xiaomi's Latest Flagship Smartphones 3
... will use a $120,000 grant from the Foundation for AIDS ... cells it attacks have evolved together over time. The goal ... When HIV infiltrates cells, the virus hijacks its host,s ... has been recently found that the retrovirus hijacks about 1,000 ...
... by researchers at the Montreal Neurological Institute (MNI), ... provides vital insights into the neurological basis of ... some instances develop various addictions when undergoing medical ... 25) issue of the scientific journal Neuron ...
... new statistical model could be used to predict an ... the Children,s Hospital Informatics Program (CHIP). Using genetic information ... predictive model could estimate an individual,s overall risk of ... -- with 86 percent accuracy. The findings are reported ...
Cached Biology News:Evolutionary biologist will study HIV with grant from AIDS research foundation 2Addiction: Insights from Parkinson's disease 2Predicting risk of stroke from one's genetic blueprint 2
(Date:7/7/2015)... ... 2015 , ... Co-located major European conferences in optical metrology ... Nobel Laureates who presented during an International Year of Light (IYL2015) ... SPIE Optical Metrology (SPIE OM) and the SPIE/OSA European Conferences on ...
(Date:7/7/2015)... , July 7, 2015 ... - Gene Therapy Market Analysis" report is an ... gene therapy field. Using detailed company data, deal ... provides an in-depth analysis of the current and ... The report discusses the key factors shaping and ...
(Date:7/7/2015)... 7, 2015 Genes in Space, a ... is landing at New England Biolabs® (NEB®) along ... of scientific exploration and celebration, on Thursday, July ... between Boeing®, The Center for Advancement of Science ... students to design an experiment to solve a ...
(Date:7/7/2015)... Mass. (PRWEB) , ... July 07, 2015 , ... ... a growing demand for biologic are some of the factors driving the pharmaceutical ... of drug manufacturers, as well as contract manufacturing organizations (CMOs), are driving market ...
Breaking Biology Technology:Light-Based Technologies at Work: ‘Seeing’ Through Walls, Monitoring Cancer Treatments and Air Pollution, Preserving Artworks -- and Much More 2Light-Based Technologies at Work: ‘Seeing’ Through Walls, Monitoring Cancer Treatments and Air Pollution, Preserving Artworks -- and Much More 3Light-Based Technologies at Work: ‘Seeing’ Through Walls, Monitoring Cancer Treatments and Air Pollution, Preserving Artworks -- and Much More 4Light-Based Technologies at Work: ‘Seeing’ Through Walls, Monitoring Cancer Treatments and Air Pollution, Preserving Artworks -- and Much More 5PharmaSphere: Emerging Biotechnologies - Gene Therapy Market Analysis 2Genes in Space finalists attend laboratory workshop and celebration at New England Biolabs' headquarters 2More Drug Companies Increasing Outsourcing Budgets; CMO Partners Spring Up as Market Thrives, According to BCC Research 2More Drug Companies Increasing Outsourcing Budgets; CMO Partners Spring Up as Market Thrives, According to BCC Research 3
... Cardium Therapeutics (Amex:,CXM) announced today that Richard A. ... is an early pioneer of coronary stent,technology and is ... stent, the Palmaz-Schatz stent. Dr. Schatz is Research Director ... at,Scripps Clinic in La Jolla, California. He is also ...
... ... in Rockville, MD, ... NVAX ), the State of Maryland and Montgomery County ... the company,s headquarters in Rockville, Maryland. The 5,000,square-foot, $5 million ...
... "Anatomy of a Deal - BioMS Medical and Eli ... - BioMS Medical Corp (TSX: MS),a leading developer in ... Kevin Giese, President and CEO, BioMS Medical and Buu ... will take part in a speciality panel session at ...
Cached Biology Technology:Richard A. Schatz, M.D. Joins Cardium's Scientific Advisory Board 2Richard A. Schatz, M.D. Joins Cardium's Scientific Advisory Board 3Richard A. Schatz, M.D. Joins Cardium's Scientific Advisory Board 4Novavax Opens Its First U.S. Vaccine Plant 2Novavax Opens Its First U.S. Vaccine Plant 3Novavax Opens Its First U.S. Vaccine Plant 4BioMS Medical to Participate in Speciality Panel Session at BioFinance 2008 2BioMS Medical to Participate in Speciality Panel Session at BioFinance 2008 3
... (RNA polymers) are prepared ... of the enzyme, polynucleotide ... and the appropriate, ribonucleoside ... the exception of catalog ...
...
Anti-Tissue Trans-glutaminase (IgA) EIA Sample Size: 10 l...
... PCR (MSP) is a new technology ... methylation utilizing small amounts of DNA ... bisulfite reaction to modify the DNA, ... primers designed to distinguish methylated from ...
Biology Products: