Navigation Links
Tiny tool to control growing blood vessels opens new potential in tumor research
Date:2/20/2009

Researchers at Uppsala University have developed a new tool that makes it possible to study the signals in the body that control the generation of blood vessels. The researchers' findings, published in the new issue of Lab on a Chip, enable scientists to determine what signals in the body attract or repel blood vessels, knowledge that is extremely interesting in tumor research.

The new invention is a tiny cell cultivation chamber of silicon plastic in which researchers can cultivate blood-vessel-rich tissue and simultaneously create targeted signals that instruct the vessels to go in a certain direction. This is of great interest to the international research world.

Angiogenesis is the process in the body that forms new blood cells, a process that is vital for life but can also be fatal in the worst case. Angiogenesis is desirable, for instance, in connection with wound healing, when new tissue needs to be grown. Undesirable angiogenesis, on the other hand, often occurs in connection with tumor growth. Through the newly generated blood vessels in the vicinity of the tumor, tumor cells receive nourishment and oxygen, which creates the conditions for tumor growth. One way to limit tumor growth may therefore be to counteract the new formation of blood vessels in the tumor, thereby cutting off the supply of nourishment and oxygen to the diseased area.

The scientists Irmeli Berkefors and Johan Kreuger's research is geared toward understanding the signals that control both normal and pathological angiogenesis. To understand this, it is important to construct experimental model systems in which they can study how concentration gradients of various signal proteins affect the direction in which a vessel grows.

"Our new method enables us to recreate and study gradients that control how blood vessels grow in the body. This is something of a research breakthrough. Now we can systematically evaluate newly identified signals that we hope can ultimately be used to control angiogenesis," says Johan Kreuger.

The method can also be used to unearth new knowledge regarding how tumor cells and nerve cells grow and move toward gradients of signal proteins.


'/>"/>

Contact: Johan Kreuger
johan.kreuger@imbim.uu.se
46-018-471-4366
Uppsala University
Source:Eurekalert  

Related biology news :

1. Forget the freezer: Research suggests novel way to control water behavior
2. Controlling cucumber beetles organically
3. Nanotubes tapestry controls its growth
4. Control of blood vessels a possible weapon against obesity
5. Vitamins C and E and beta carotene again fail to reduce cancer risk in randomized controlled trial
6. Organic plant waste proves effective weed control for citrus trees
7. Motor nerve targeting to limb muscles is controlled by ephrin proteins
8. New satellite data reveal impact of Olympic pollution controls
9. Brain enzyme may play key role in controlling appetite and weight gain
10. Fractional dose of scarce meningitis vaccine may be effective in outbreak control
11. New control knobs for stem cells identified
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Tiny tool to control growing blood vessels opens new potential in tumor research
(Date:4/17/2017)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... 2016 Annual Report on Form 10-K on Thursday April 13, 2017 ... ... Investor Relations section of the Company,s website at http://www.nxt-id.com  under ... http://www.sec.gov . 2016 Year Highlights: ...
(Date:4/11/2017)... 2017 Research and Markets has announced the ... to their offering. ... eye tracking market to grow at a CAGR of 30.37% during ... Market 2017-2021, has been prepared based on an in-depth market analysis ... and its growth prospects over the coming years. The report also ...
(Date:4/5/2017)... Allen Institute for Cell Science today announces the launch ... dynamic digital window into the human cell. The website ... deep learning to create predictive models of cell organization, ... suite of powerful tools. The Allen Cell Explorer will ... resources created and shared by the Allen Institute for ...
Breaking Biology News(10 mins):
(Date:8/16/2017)... England , Aug. 16, 2017  Kingfisher Talent, the ... and leadership development, and Virdis Group, global executive search specialists ... alliance that enables clients to leverage the expertise and reach ... our clients here in the Boston ... population of leadership talent throughout the US, Canada ...
(Date:8/15/2017)... ... ... Any expert in stem cell research or stem cell medicine knows well ... century. Despite their essential roles in human health and regenerative medicine, adult tissue ... for this purpose also tag other, more abundant, non-stem tissue cells ( See 2017 ...
(Date:8/14/2017)... ... August 14, 2017 , ... Every ... Key researchers in the antibody community have recently come together to address this ... in the laboratory. , The team at Thermo Fisher Scientific ...
(Date:8/11/2017)... ... 11, 2017 , ... Algenist continues to disrupt the skincare industry with today’s ... , Collagen is the key structural element skin needs to maintain its youthful ... , First to market with proprietary collagen water active ...
Breaking Biology Technology: