Navigation Links
Tiny tool to control growing blood vessels opens new potential in tumor research

Researchers at Uppsala University have developed a new tool that makes it possible to study the signals in the body that control the generation of blood vessels. The researchers' findings, published in the new issue of Lab on a Chip, enable scientists to determine what signals in the body attract or repel blood vessels, knowledge that is extremely interesting in tumor research.

The new invention is a tiny cell cultivation chamber of silicon plastic in which researchers can cultivate blood-vessel-rich tissue and simultaneously create targeted signals that instruct the vessels to go in a certain direction. This is of great interest to the international research world.

Angiogenesis is the process in the body that forms new blood cells, a process that is vital for life but can also be fatal in the worst case. Angiogenesis is desirable, for instance, in connection with wound healing, when new tissue needs to be grown. Undesirable angiogenesis, on the other hand, often occurs in connection with tumor growth. Through the newly generated blood vessels in the vicinity of the tumor, tumor cells receive nourishment and oxygen, which creates the conditions for tumor growth. One way to limit tumor growth may therefore be to counteract the new formation of blood vessels in the tumor, thereby cutting off the supply of nourishment and oxygen to the diseased area.

The scientists Irmeli Berkefors and Johan Kreuger's research is geared toward understanding the signals that control both normal and pathological angiogenesis. To understand this, it is important to construct experimental model systems in which they can study how concentration gradients of various signal proteins affect the direction in which a vessel grows.

"Our new method enables us to recreate and study gradients that control how blood vessels grow in the body. This is something of a research breakthrough. Now we can systematically evaluate newly identified signals that we hope can ultimately be used to control angiogenesis," says Johan Kreuger.

The method can also be used to unearth new knowledge regarding how tumor cells and nerve cells grow and move toward gradients of signal proteins.


Contact: Johan Kreuger
Uppsala University

Related biology news :

1. Forget the freezer: Research suggests novel way to control water behavior
2. Controlling cucumber beetles organically
3. Nanotubes tapestry controls its growth
4. Control of blood vessels a possible weapon against obesity
5. Vitamins C and E and beta carotene again fail to reduce cancer risk in randomized controlled trial
6. Organic plant waste proves effective weed control for citrus trees
7. Motor nerve targeting to limb muscles is controlled by ephrin proteins
8. New satellite data reveal impact of Olympic pollution controls
9. Brain enzyme may play key role in controlling appetite and weight gain
10. Fractional dose of scarce meningitis vaccine may be effective in outbreak control
11. New control knobs for stem cells identified
Post Your Comments:
Related Image:
Tiny tool to control growing blood vessels opens new potential in tumor research
(Date:10/26/2015)...  Delta ID Inc., a company focused on bringing ... devices, announced its ActiveIRIS® technology powers the iris recognition ... by NTT DOCOMO, INC in Japan ... to include iris recognition technology, after a very successful ... May 2015, world,s first smartphone to have this capability. ...
(Date:10/23/2015)... and GOLETA, California , ... HFES conference, BIOPAC and SensoMotoric Instruments (SMI) announce a ... eye tracking data captured during interactive real-world tasks ... and play integration of their established wearable solutions for ... to synchronize gaze behavior captured with SMI Eye ...
(Date:10/22/2015)... SAN JOSE, Calif., Oct. 22, 2015  Synaptics (NASDAQ: SYNA ... results for its first quarter ended September 30, 2015. ... first quarter of fiscal 2016 grew 66 percent over the comparable ... quarter of fiscal 2016 was $23.8 million, or $0.62 per diluted ... net income for the first quarter of fiscal 2016 grew 39 ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... India , November 24, 2015 ... a new market research report "Oligonucleotide Synthesis Market by ... Application (PCR, Gene Synthesis, Diagnostic, DNA, RNAi), End-User (Research, ... 2020", published by MarketsandMarkets, the market is expected to ... Million in 2015, at a CAGR of 10.1% during ...
(Date:11/24/2015)... IN (PRWEB) , ... November 24, 2015 , ... The ... newest Special Interest Group (SIG), MultiGP, also known as Multirotor Grand Prix, to represent ... the last few years. Many AMA members have embraced this type of racing and ...
(Date:11/24/2015)... 24, 2015 --> ... report released by Transparency Market Research, the global non-invasive ... CAGR of 17.5% during the period between 2014 and ... Global Industry Analysis, Size, Volume, Share, Growth, Trends and ... testing market to reach a valuation of US$2.38 bn ...
(Date:11/24/2015)... /PRNewswire/ - Aeterna Zentaris Inc. (NASDAQ:  AEZS) (TSX: ... 11,000 post-share consolidation (or 1,100,000 pre-share consolidation) Series ... Warrants") subject to the previously disclosed November 1, ... which will result in the issuance of 365,518 ... issuance of such shares, there will be approximately ...
Breaking Biology Technology: