Navigation Links
Tiny tool to control growing blood vessels opens new potential in tumor research
Date:2/20/2009

Researchers at Uppsala University have developed a new tool that makes it possible to study the signals in the body that control the generation of blood vessels. The researchers' findings, published in the new issue of Lab on a Chip, enable scientists to determine what signals in the body attract or repel blood vessels, knowledge that is extremely interesting in tumor research.

The new invention is a tiny cell cultivation chamber of silicon plastic in which researchers can cultivate blood-vessel-rich tissue and simultaneously create targeted signals that instruct the vessels to go in a certain direction. This is of great interest to the international research world.

Angiogenesis is the process in the body that forms new blood cells, a process that is vital for life but can also be fatal in the worst case. Angiogenesis is desirable, for instance, in connection with wound healing, when new tissue needs to be grown. Undesirable angiogenesis, on the other hand, often occurs in connection with tumor growth. Through the newly generated blood vessels in the vicinity of the tumor, tumor cells receive nourishment and oxygen, which creates the conditions for tumor growth. One way to limit tumor growth may therefore be to counteract the new formation of blood vessels in the tumor, thereby cutting off the supply of nourishment and oxygen to the diseased area.

The scientists Irmeli Berkefors and Johan Kreuger's research is geared toward understanding the signals that control both normal and pathological angiogenesis. To understand this, it is important to construct experimental model systems in which they can study how concentration gradients of various signal proteins affect the direction in which a vessel grows.

"Our new method enables us to recreate and study gradients that control how blood vessels grow in the body. This is something of a research breakthrough. Now we can systematically evaluate newly identified signals that we hope can ultimately be used to control angiogenesis," says Johan Kreuger.

The method can also be used to unearth new knowledge regarding how tumor cells and nerve cells grow and move toward gradients of signal proteins.


'/>"/>

Contact: Johan Kreuger
johan.kreuger@imbim.uu.se
46-018-471-4366
Uppsala University
Source:Eurekalert  

Related biology news :

1. Forget the freezer: Research suggests novel way to control water behavior
2. Controlling cucumber beetles organically
3. Nanotubes tapestry controls its growth
4. Control of blood vessels a possible weapon against obesity
5. Vitamins C and E and beta carotene again fail to reduce cancer risk in randomized controlled trial
6. Organic plant waste proves effective weed control for citrus trees
7. Motor nerve targeting to limb muscles is controlled by ephrin proteins
8. New satellite data reveal impact of Olympic pollution controls
9. Brain enzyme may play key role in controlling appetite and weight gain
10. Fractional dose of scarce meningitis vaccine may be effective in outbreak control
11. New control knobs for stem cells identified
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Tiny tool to control growing blood vessels opens new potential in tumor research
(Date:1/4/2017)... VEGAS , Jan. 4, 2017  CES ... performance biometric sensor technology, today announced the launch ... sensor systems, the highly-accurate biometric sensor modules ... biometric technology, experience and expertise. The two ... Benchmark designed specifically for hearables, and Benchmark BW2.0, ...
(Date:12/22/2016)... YORK , December 22, 2016 ... provider of secure solutions for the e-Government, Public Safety, HealthCare, and ... subsidiary of SuperCom, has been selected to implement and deploy a ... in Northern California , further expanding its presence ... ...
(Date:12/19/2016)... 19 de diciembre de 2016  Mosaic Biomedicals SL anunció hoy ... de MSC-1, un anticuerpo humanizado que se espera comenzar a utilizar ... múltiples sitios previstos a lo largo de Europa y Norteamérica. ... MSC-1 es el primer ... leucemia (LIF), una citoquina pleiotrópica que se sobreexpresa en ciertos tumores ...
Breaking Biology News(10 mins):
(Date:1/20/2017)... January 20, 2017 http://www.Financialbuzz.com ... one of leading causes of death worldwide. There were ... number of cancer related deaths increased gradually over time, ... incidence rate of various cancers continues to drive demand ... report by Global Market Insights, Inc. cancer biological therapy ...
(Date:1/19/2017)... SHANGHAI , Jan. 19, 2017 /PRNewswire -- ... medical device open-access capability and technology platform, today ... a leading biology focused preclinical drug discovery contract ... Biosciences will become a wholly-owned subsidiary of WuXi, ... core competences and providing greater services. The acquisition ...
(Date:1/19/2017)... 2017  ArmaGen, Inc., today announced that it ... chief executive officer, as well as a member ... ArmaGen more than 17 years of executive management ... biotherapeutics and pharmaceuticals. "Mathias is ... and skillset necessary to lead ArmaGen to its ...
(Date:1/19/2017)... ... January 19, 2017 , ... ... services spanning the full spectrum of drug and device development, and Prism ... pharma/device companies and clinicians, today announced Verified Clinical Trials (VCT) has ...
Breaking Biology Technology: