Navigation Links
Tiny tool to control growing blood vessels opens new potential in tumor research
Date:2/20/2009

Researchers at Uppsala University have developed a new tool that makes it possible to study the signals in the body that control the generation of blood vessels. The researchers' findings, published in the new issue of Lab on a Chip, enable scientists to determine what signals in the body attract or repel blood vessels, knowledge that is extremely interesting in tumor research.

The new invention is a tiny cell cultivation chamber of silicon plastic in which researchers can cultivate blood-vessel-rich tissue and simultaneously create targeted signals that instruct the vessels to go in a certain direction. This is of great interest to the international research world.

Angiogenesis is the process in the body that forms new blood cells, a process that is vital for life but can also be fatal in the worst case. Angiogenesis is desirable, for instance, in connection with wound healing, when new tissue needs to be grown. Undesirable angiogenesis, on the other hand, often occurs in connection with tumor growth. Through the newly generated blood vessels in the vicinity of the tumor, tumor cells receive nourishment and oxygen, which creates the conditions for tumor growth. One way to limit tumor growth may therefore be to counteract the new formation of blood vessels in the tumor, thereby cutting off the supply of nourishment and oxygen to the diseased area.

The scientists Irmeli Berkefors and Johan Kreuger's research is geared toward understanding the signals that control both normal and pathological angiogenesis. To understand this, it is important to construct experimental model systems in which they can study how concentration gradients of various signal proteins affect the direction in which a vessel grows.

"Our new method enables us to recreate and study gradients that control how blood vessels grow in the body. This is something of a research breakthrough. Now we can systematically evaluate newly identified signals that we hope can ultimately be used to control angiogenesis," says Johan Kreuger.

The method can also be used to unearth new knowledge regarding how tumor cells and nerve cells grow and move toward gradients of signal proteins.


'/>"/>

Contact: Johan Kreuger
johan.kreuger@imbim.uu.se
46-018-471-4366
Uppsala University
Source:Eurekalert  

Related biology news :

1. Forget the freezer: Research suggests novel way to control water behavior
2. Controlling cucumber beetles organically
3. Nanotubes tapestry controls its growth
4. Control of blood vessels a possible weapon against obesity
5. Vitamins C and E and beta carotene again fail to reduce cancer risk in randomized controlled trial
6. Organic plant waste proves effective weed control for citrus trees
7. Motor nerve targeting to limb muscles is controlled by ephrin proteins
8. New satellite data reveal impact of Olympic pollution controls
9. Brain enzyme may play key role in controlling appetite and weight gain
10. Fractional dose of scarce meningitis vaccine may be effective in outbreak control
11. New control knobs for stem cells identified
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Tiny tool to control growing blood vessels opens new potential in tumor research
(Date:6/5/2020)... ... June 04, 2020 , ... “Although we are disappointed to have ... our attendees, staff, and the public. We remain committed to creating a global ... collaborate virtually,” said Julie Sutcliffe, President of WMIS. , The abstract ...
(Date:5/30/2020)... ... May 29, 2020 , ... eInfochips, ... enterprises globally, has collaborated with EchoNous Inc. to develop the cloud-based connected health ... systolic heart function, which has been clinically tested versus expert measurements, yielding improved ...
(Date:5/28/2020)... WILMINGTON, Del. (PRWEB) , ... ... ... & Biosciences (DuPont) has announced a new enzyme solution for adjunct liquefaction: ... distilleries alike including the ability to expand into new segments with locally-sourced ...
Breaking Biology News(10 mins):
(Date:6/23/2020)... ... June 22, 2020 , ... Dracen Pharmaceuticals Inc., announced ... June 22-24 during the American Association for Cancer Research Virtual meeting. One poster ... potent, consistent single agent activity in KEAP1 mutant tumor models of NSCLC. ...
(Date:6/11/2020)... ... June 09, 2020 , ... PathSensors Inc., a ... Business Innovation Research (SBIR) program funded by the National Institute of Food and ... the Field”. The project’s goal was to engineer and develop a field-deployable instrument ...
(Date:6/2/2020)... (PRWEB) , ... June 01, 2020 , ... ... hand to companies and encourage positive change in the world, enterprise security solutions ... pandemic. , With more people working from home during self-quarantines and shelter-in-place orders, ...
(Date:5/28/2020)... ... May 28, 2020 , ... The Security Industry Association (SIA) and ... winners of the Women in Biometrics Awards – a globally recognized program ... Update and the SIA Women in Security Forum . The honorees will ...
Breaking Biology Technology: