Navigation Links
Tiny proteins have outsized influence on nerve health
Date:1/6/2014

Mutations in small proteins that help convey electrical signals throughout the body may have a surprisingly large effect on health, according to results of a new Johns Hopkins study study published in Proceedings of the National Academy of Sciences in December using spider, scorpion and sea anemone venom.

The tiny conduits carrying those electrical signals are sodium channels that are vital to our well-beingthey trigger action potentials, or spurts of electrical energy that course from body to brain to deliver messages that invoke feelings like pain or temperature sensitivity. When such channels go awry, they contribute to a slew of diseases, one of which is epilepsy.

In the new research, Frank Bosmans, Ph.D., an assistant professor of physiology at the Johns Hopkins University School of Medicine, has found that auxiliary "helper" proteins that interact with sodium channels also play a crucial role. And that, he says, could affect drug development for epilepsy, neurological diseases, muscular disorders and pain syndromes.

"Nobody had thought these tiny molecules that don't even form the main sodium channel were capable of changing the response of the channel to certain compounds," Bosmans says. "But in what we consider a new concept, these auxiliary subunits can be considered as drug targets."

Over the past few decades, there have been hints that these auxiliary proteins were influencing sodium channels, but few analyzed the problem very closely. John Gilchrist, a graduate student in Bosmans' lab, began evaluating each of the four proteins, one at a time.

Gilchrist engineered frog eggs that made sodium channels and exposed them to the toxins released by tarantulas, scorpions, wasps and sea anemones, an extension of Bosmans' earlier doctoral research studying the effect of animal venoms on sodium channels. He found that one auxiliary protein in particular, beta4, altered the whole sodium channel system
'/>"/>

Contact: Vanessa McMains
vmcmain1@jhmi.edu
410-502-9410
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. More effective method of imaging proteins
2. Gold nanoantennas detect proteins
3. Discovery of a new family of key mitochondrial proteins for the function and viability of the brain
4. Discovery of plant proteins may boost agricultural yields and biofuel production
5. UCLA researchers develop way to strengthen proteins with polymers
6. Discovered a new checkpoint of cell cycle control through joint action of 2 proteins
7. A non-invasive intracellular thermometer with fluorescent proteins has been created
8. Speeding up drug discovery with rapid 3-D mapping of proteins
9. Identification of differential proteins in maternal serum with Down syndrome
10. Neiker-Tecnalia identifies antitumour proteins in the latex of the plant Euphorbia trigona
11. The appetite-suppressing effect of proteins explained
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2014)... for sniffing the highly infectious bacteria C. diff ... been developed by a team at the University of ... has demonstrated that it is possible to identify the ... lead to rapid diagnosis of the condition., What is ... to identify different strains of the disease simply from ...
(Date:8/31/2014)... Nature Climate Change , suggests that if current ... exceed, the global targets for total greenhouse gas (GHG) emissions ... all think carefully about the food we choose and its ... is just one of a number of actions that need ... there is enough food for all. , As populations ...
(Date:8/29/2014)... 2014) Scientists at the Barshop Institute for Longevity ... at the UT Health Science Center at San Antonio, ... of the longest-lived rodent, the naked mole rat. ... of naked mole rats protects and alters the activity ... obsolete proteins. , The factor also protects proteasome function ...
Breaking Biology News(10 mins):Scientists develop 'electronic nose' for rapid detection of C. diff infection 2Changing global diets is vital to reducing climate change 2Changing global diets is vital to reducing climate change 3Changing global diets is vital to reducing climate change 4Factor in naked mole rat's cells enhances protein integrity 2
... rate of pine tree seedlings by changing when and ... "There's been too many (reforestation) failures over the last ... Extension forestry specialist. , "Some landowners have had to ... row because of poor seedling survival." , Second-year data ...
... The University of Texas M. D. Anderson Cancer Center ... so that it permanently hampers breast cancer development. The ... in some human breast tumors, thus reducing the cancer's ... the annual meeting of the American Association for Cancer ...
... Carolina at Chapel Hill is one of five clinical ... of Health to study why good medications are sometimes ... years, the Drug-Induced Liver Injury Network, or DILIN, will ... by prescription and over-the-counter medications, nutritional supplements, alternative medicines ...
Cached Biology News:Shift of weather patterns necessitates rethinking of reforestation methods 2Shift of weather patterns necessitates rethinking of reforestation methods 3Used in a new way, RNA interference permanently silences key breast cancer gene 2UNC launches study of liver injury caused by drugs 2
(Date:8/30/2014)... The Global and China Electrical Insulating ... on the current state of the Electrical Insulating ... report provides a basic overview of the industry, ... market analysis and Chinese domestic market analysis are ... and competitive landscape of the market. A comparison ...
(Date:8/29/2014)... Pittcon is pleased to announce that the ... Horiba Scientific, have organized a session on nanotechnology for ... , Asia’s largest analytical and scientific instruments show, will ... , The four speakers in this U.S. symposium, ... to Single Cells” will present their use of nanotechnology ...
(Date:8/29/2014)... (PRWEB) August 29, 2014 A major ... the biotech start-up dense realm of Boston-Cambridge, is gaining ... able investors. James Sherley, the Director of Boston’s Adult ... the local and national visibility of his company an ... 2013. , In addition to a social media marketing ...
(Date:8/28/2014)... August 28, 2014 “This kit has an ... screen from 0 to 150 ppb,” said Mark Tess, PhD, ... significant benefit to plant owners and USDA-GIPSA inspection agencies that ... commodities. Testing can take place in a matter of minutes ... the plant test the feed and grain before accepting it, ...
Breaking Biology Technology:Electrical Insulating Varnish Market World, China Regional Analysis & 2020 Forecasts Available at DeepResearchReports.com 2Electrical Insulating Varnish Market World, China Regional Analysis & 2020 Forecasts Available at DeepResearchReports.com 3Fifth Annual U.S. Symposium at JASIS Organized by Pittcon’s Program Chairman Hub MacDonald 2The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 2The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 3The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 4
... today announced a commitment of more than a half million ... the ACC Foundation to fund and support a new ACC ... $530,000 contribution will be to offer financial support through research ... ,This awards program is an investment in young researchers and ...
... between Wisconsins biotechnology sector and other well-established biotech regions ... Engineering News featuring Wisconsins biotech sector as Americas ... leaders. , ,The East and West Coasts are often ... to flourish, some believe Wisconsin is catching up. According ...
... as social networking has. In fact, I get more mail when ... all other topics combined. (Something I suppose I should keep in ... ,Last week, I wrote that social networking "eludes a business model ... in actively working the network to your business benefit. Whatever the ...
Cached Biology Technology:Wisconsin's biotech industry recognized by national publication 2Social networks: Readers respond 2Social networks: Readers respond 3Social networks: Readers respond 4
...
... the first all-inclusive collection of key procedures ... System. Methods developed by the leaders in ... protocols. This book will guide you from ... construction and analysis, to production of your ...
...
...
Biology Products: