Navigation Links
Tiny proteins have outsized influence on nerve health
Date:1/6/2014

Mutations in small proteins that help convey electrical signals throughout the body may have a surprisingly large effect on health, according to results of a new Johns Hopkins study study published in Proceedings of the National Academy of Sciences in December using spider, scorpion and sea anemone venom.

The tiny conduits carrying those electrical signals are sodium channels that are vital to our well-beingthey trigger action potentials, or spurts of electrical energy that course from body to brain to deliver messages that invoke feelings like pain or temperature sensitivity. When such channels go awry, they contribute to a slew of diseases, one of which is epilepsy.

In the new research, Frank Bosmans, Ph.D., an assistant professor of physiology at the Johns Hopkins University School of Medicine, has found that auxiliary "helper" proteins that interact with sodium channels also play a crucial role. And that, he says, could affect drug development for epilepsy, neurological diseases, muscular disorders and pain syndromes.

"Nobody had thought these tiny molecules that don't even form the main sodium channel were capable of changing the response of the channel to certain compounds," Bosmans says. "But in what we consider a new concept, these auxiliary subunits can be considered as drug targets."

Over the past few decades, there have been hints that these auxiliary proteins were influencing sodium channels, but few analyzed the problem very closely. John Gilchrist, a graduate student in Bosmans' lab, began evaluating each of the four proteins, one at a time.

Gilchrist engineered frog eggs that made sodium channels and exposed them to the toxins released by tarantulas, scorpions, wasps and sea anemones, an extension of Bosmans' earlier doctoral research studying the effect of animal venoms on sodium channels. He found that one auxiliary protein in particular, beta4, altered the whole sodium channel system
'/>"/>

Contact: Vanessa McMains
vmcmain1@jhmi.edu
410-502-9410
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. More effective method of imaging proteins
2. Gold nanoantennas detect proteins
3. Discovery of a new family of key mitochondrial proteins for the function and viability of the brain
4. Discovery of plant proteins may boost agricultural yields and biofuel production
5. UCLA researchers develop way to strengthen proteins with polymers
6. Discovered a new checkpoint of cell cycle control through joint action of 2 proteins
7. A non-invasive intracellular thermometer with fluorescent proteins has been created
8. Speeding up drug discovery with rapid 3-D mapping of proteins
9. Identification of differential proteins in maternal serum with Down syndrome
10. Neiker-Tecnalia identifies antitumour proteins in the latex of the plant Euphorbia trigona
11. The appetite-suppressing effect of proteins explained
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... have developed a unique method to use microbes buried ... areas. , The first microbe-powered, self-sustaining wastewater treatment ... to clean up waste from large farming operations and ... Professor Haluk Beyenal and graduate student Timothy Ewing in ... system in the online edition of Journal of ...
(Date:9/18/2014)... icy moon of Uranus, is one of the most ... Despite its relatively small size, Miranda appears to have ... the formation of at least three remarkable and unique ... These coronae are visible in Miranda,s southern hemisphere, and ... corona, the largest, has ridges and troughs with up ...
(Date:9/18/2014)... researchers from McGill University and the Quebec government ... ,microbeads, Canadian Journal of Fisheries and Aquatic ... cosmetics, household cleansers, or industrial cleansers, to which ... their small size and buoyancy, they may readily ... a global contaminant in the world,s oceans, but ...
Breaking Biology News(10 mins):Researchers develop unique waste cleanup for rural areas 2Miranda: An icy moon deformed by tidal heating 2Miranda: An icy moon deformed by tidal heating 3Miranda: An icy moon deformed by tidal heating 4Miranda: An icy moon deformed by tidal heating 5Miranda: An icy moon deformed by tidal heating 6Miranda: An icy moon deformed by tidal heating 7Microplastic pollution discovered in St. Lawrence River sediments 2
... 16, 2008) The overall condition of the nation,s coastal ... environmental assessment. The National Coastal Condition Report III (NCCRIII) ... of U.S. coastal and Great Lakes waters. ... Protection Agency (EPA); the National Oceanic and Atmospheric Administration ...
... Plants, genetically modified to ease the breaking down of their ... greener way of making ethanol, according to researchers who add ... food for livestock. Lignin, a major component of ... plants with the strength to withstand strong gusts of wind ...
... NEW YORK, Dec. 22, 2008 NYU Langone Medical Center ... La Jolla, Calif., have discovered an unexpected cause for the ... of the central nervous system, according to a study published ... new way of thinking about how the human immune system ...
Cached Biology News:Modified plants may yield more biofuel 2Peering inside the skull of a mouse to solve meningitis mystery 2Peering inside the skull of a mouse to solve meningitis mystery 3
(Date:9/18/2014)... September 18, 2014 On Tuesday, Secretary ... Sen. Jim Risch for National Lab Day on the ... across the national laboratory system. Durbin and Risch also ... to increase awareness of the reach of the national ... discoveries to address some of our nation's most pressing ...
(Date:9/18/2014)... Research and Markets has announced the addition ... In-situ hybridization, Immunohistochemistry) Market - Trends & Forecasts to ... The global companion diagnostics market is expected to grow ... Factors such as rising need for personalized medicine in ... pharmaceutical industry, support from regulatory authorities, and emerging technologies ...
(Date:9/18/2014)... , Sept. 18, 2014  Neogen Corporation (Nasdaq: ... into a strategic agreement with Merck Animal Health to ... The Igenity Dairy Heifer Program consists of ... on the genetic potential of replacement dairy heifers. The ... is born, and is an excellent tool in the ...
(Date:9/18/2014)... (PRWEB) September 18, 2014 OMICS ... the globe to participate in the ‘Open Access ... articles to OMICS Group Pharma Journals ... one of the fastest emerging Sciences, accelerating with ... healthcare services across the globe. The industry is ...
Breaking Biology Technology:Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 2Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 3Global Companion Diagnostics (Polymerase Chain Reaction, In-situ hybridization, Immunohistochemistry) Market - Trends & Forecasts to 2019 2Global Companion Diagnostics (Polymerase Chain Reaction, In-situ hybridization, Immunohistochemistry) Market - Trends & Forecasts to 2019 3Merck Animal Health to market Neogen's dairy genomic program 2Pharma and Omics Journals to Address Global Challenges during Open Access Week 2Pharma and Omics Journals to Address Global Challenges during Open Access Week 3
... A study that examines a new type of ... function and how repeated use could wear them ... this material performs better than silicon alone. With ... lithium battery electrodes, silicon-carbon nanocomposite electrodes could lead ...
... extensive national search, Fitzsimons Redevelopment Authority (FRA) has named ... Officer, beginning in late May. The announcement is made ... of Directors, who said: "Steve, a seasoned leader in ... Clinic in Rochester, Minnesota." The appointment of ...
... March 14, 2012   Chemring Detection Systems ("CDS") ... $9M contract award to supply biological detection systems to ... by Marubeni Aerospace Corporation. The systems will be installed in ... Vehicle. The system is a variant ...
Cached Biology Technology:Silicon-carbon electrodes snap, swell, don't pop 2Silicon-carbon electrodes snap, swell, don't pop 3Silicon-carbon electrodes snap, swell, don't pop 4Fitzsimons Redevelopment Authority Names New President & CEO 2Chemring Detection Systems Awarded $9M for Biological Detection Systems 2
... Red System consists of concentrated X/R ... X/R Red Buffer. The X/R Red ... produce red staining that may be ... Buffer, 100 mL , Chromogen, 2.0 ...
... Chromogen System consists of FAST ... FAST RED reacts in the ... produce red staining with minimal ... The FAST RED tablets provides ...
Mouse Cell Line Slides...
Human Cell Line Slides...
Biology Products: