Navigation Links
Tiny protein provokes healthy bonding between cells
Date:11/25/2008

In human relationships, a certain "spark" often governs whether we prefer one person to another, and critical first impressions can occur within seconds. A team lead by Johns Hopkins researchers has found that cell-to-cell "friendships" operate in much the same way and that dysfunctional bonding is linked to the spread of cancer.

The research was published in the Nov. 18 early online edition of the Proceedings of the National Academies of Sciences and appears in the journal's Nov. 25 print edition.

"Bonding between cells has important health implications," said the study's senior author, Denis Wirtz, a professor of chemical and biomolecular engineering in the Whiting School of Engineering at Johns Hopkins. "When cancer cells break free from their neighbors, they can spread the disease through the body. If we can learn more about this process, we may find new ways to keep cancer in check."

Toward that goal, Wirtz, who also is associate director of the Johns Hopkins Institute for NanoBioTechnology, led a multi-institution team that focused on alpha-catenin, a small protein that floats in the cytoplasm, the gel-like material that surrounds the nucleus inside a cell. Alpha-catenin allows cells to recognize neighboring cells as "friends" almost immediately, leading to the creation of many strong bonds that are hard to break. However, cancer cells, including those found in diffuse gastric cancer and lung cancer, possess dysfunctional alpha-catenin and form very weak bonds with their neighbors. This allows them to break free from cell masses and spread cancer throughout the body.

To better understand these bonding characteristics, Wirtz and his colleagues used a technique called atomic force microscopy to study single cells with and without functioning alpha-catenin. This technique records tiny forces, measured in nanoNewtons, that cells exert upon one another.

Wirtz's team discovered that normal cells with properly functioning alpha-catenin formed bonds that were four times more stable than those without functional alpha-catenin, and these first bonds formed in less than 1 millisecond. The longer the cells remained in contact with one another, the more numerous and stronger these bonds became. The connections between these cells resembled those that occur with a popular type of fastener material. "This accelerated formation of additional bonds between neighboring cells was akin to the 'Velcro' effect," Wirtz said.

In contrast, cells without functional alpha-catenin formed weak bonds from the onset. Also, even as these cells remained in contact, bonding strengths continued to diminish. Wirtz suggested that if scientists could figure out a way to repair or replace the alpha-catenin dysfunction found in some cancer cells, it could lead to a therapy that thwarts the spread of cancer.


'/>"/>

Contact: Mary Spiro
mspiro@jhu.edu
410-516-4802
Johns Hopkins University
Source:Eurekalert  

Related biology news :

1. Protein chatter linked to cancer activation
2. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
3. Researchers identify proteins involved in new neurodegenerative syndrome
4. Low levels of key protein may indicate pancreatic cancer risk
5. Structure of 450 million year old protein reveals evolutions steps
6. Scientists retrace evolution with first atomic structure of an ancient protein
7. Specific brain protein required for nerve cell connections to form and function
8. NIH awards researcher $1.5 million new innovator grant for fruit-fly studies of prion proteins
9. Interacting protein theory awaits test from new neutron analysis tools
10. Depression, aging, and proteins made by a virus may all play role in heart disease
11. Census of protein architectures offers new view of history of life
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Tiny protein provokes healthy bonding between cells
(Date:6/2/2016)... , June 2, 2016 The ... has awarded the 44 million US Dollar project, for ... Embossed Vehicle Plates including Personalization, Enrolment, and IT Infrastructure ... leader in the production and implementation of Identity Management Solutions. ... January, however Decatur was selected for ...
(Date:6/2/2016)... Perimeter Surveillance & Detection Systems, Biometrics & ... & Other Service  The latest report from ... of the global Border Security market . Visiongain ... billion in 2016. Now: In November 2015 ... and hardware technologies for advanced video surveillance. ...
(Date:5/24/2016)... care by providing unparalleled technology to leaders of the medical imaging industry.  As such, ... to the range of products distributed by Ampronix. Photo - http://photos.prnewswire.com/prnh/20160524/371420 ... ... ... With ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... 2016  Regular discussions on a range of subjects including ... two entities said Poloz. Speaking at a lecture ... , he pointed to the country,s inflation target, which is ... "In certain areas there ... common economic goals, why not sit down and address strategy ...
(Date:6/24/2016)... ... June 24, 2016 , ... Researchers at the Universita Politecnica delle Marche in ... peritoneal or pleural mesothelioma. Their findings are the subject of a new article on ... biomarkers are signposts in the blood, lung fluid or tissue of mesothelioma patients that ...
(Date:6/23/2016)...   Boston Biomedical , an industry leader ... target cancer stemness pathways, announced that its lead ... Designation from the U.S. Food and Drug Administration ... gastroesophageal junction (GEJ) cancer. Napabucasin is an orally ... stemness pathways by targeting STAT3, and is currently ...
(Date:6/23/2016)... 23, 2016 Houston Methodist Willowbrook Hospital ... Sports Association to serve as their official health ... Methodist Willowbrook will provide sponsorship support, athletic training ... association coaches, volunteers, athletes and families. ... Sports Association and to bring Houston Methodist quality ...
Breaking Biology Technology: