Navigation Links
Tiny probes shine brightly to reveal the location of targeted tissues
Date:11/20/2012

Called BRIGHTs, the tiny probes described in the online issue of Advanced Materials on Nov. 15, bind to biomarkers of disease and, when swept by an infrared laser, light up to reveal their location.

Tiny as they are, the probes are exquisitely engineered objects: gold nanoparticles covered with molecules called Raman reporters, in turn covered by a thin shell of gold that spontaneously forms a dodecahedron.

The Raman reporters are molecules whose jiggling atoms respond to a probe laser by scattering light at characteristic wavelengths.

The shell and core create an electromagnetic hotspot in the gap between them that boosts the reporters' emission by a factor of nearly a trillion.

BRIGHTs shine about 1.7 x 1011 more brightly than isolated Raman reporters and about 20 times more intensely than the next-closest competitor probe, says Srikanth Singamaneni, PhD, assistant professor of mechanical engineering and materials science in the School of Engineering & Applied Science at Washington University in St. Louis.

Goosing the signal from Raman reporters

Singamaneni and his postdoctoral research associate Naveen Gandra, PhD, tried several different probe designs before settling on BRIGHTS.

Singamaneni's lab has worked for years with Raman spectroscopy, a spectroscopic technique that is used to study the vibrational modes (bending and stretching) of molecules. Laser light interacts with these modes and the molecule then emits light at higher or lower wavelengths that are characteristic of the molecule,

Spontaneous Raman scattering, as this phenomenon is called, is by nature very weak, but 30 years ago scientists accidently stumbled on the fact that it is much stronger if the molecules are adsorbed on roughened metallic surfaces. Then they discovered that molecules attached to metallic nanoparticles shine even brighter than those attached to rough surfaces.

The intensi
'/>"/>

Contact: Diana Lutz
dlutz@wustl.edu
314-935-5272
Washington University in St. Louis
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. The shape of things to come: NIST probes the promise of nanomanufacturing using DNA origami
2. Not-so-precious: Stripping gold from AFM probes allows better measurement of picoscale forces
3. Rice University researchers optimize photoluminescent probes to study DNA and more
4. New study shines light on barriers to diabetes care in NYC Bangladeshi community
5. Research reveals first evidence of hunting by prehistoric Ohioans
6. Studies reveal structure of EV71, a virus causing childhood illnesses
7. Researchers reveal how a single gene mutation leads to uncontrolled obesity
8. Study reveals how monarch butterflies recolonize northern breeding range
9. Circadian rhythms have profound influence on metabolic output, UCI study reveals
10. Unexpected discovery reveals a new mechanism for how the cerebellum extracts signal from noise
11. Ancient civilizations reveal ways to manage fisheries for sustainability
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Tiny probes shine brightly to reveal the location of targeted tissues
(Date:7/11/2014)... Tenn., July 11, 2014--Researchers at the Department of ... R&D 100 awards, presented by R&D Magazine in ... , "These awards recognize the tremendous value of ... Moniz. "Research and development at the National Labs ... challenges and pursue the scientific and technological innovations ...
(Date:7/11/2014)... German . ... refraction of X-rays through a specimen instead of attenuation ... are often of much higher quality than those based ... Franz Pfeiffer are particularly interested in developing new approaches ... phase-contrast imaging. One main goal is to make this ...
(Date:7/11/2014)... develop relationships with other group members to reduce aggression ... baboons the strategy for grooming activities shows a certain ... in the scientific journal Biology Letters . , ... not practiced without ulterior motives. To be groomed has ... while grooming another individual can provide access to infants, ...
Breaking Biology News(10 mins):ORNL wins eight R&D 100s 2ORNL wins eight R&D 100s 3ORNL wins eight R&D 100s 4New simple setup for X-ray phase contrast 2Baboons groom early in the day to get benefits later 2
... can complicate treatment after many surgical procedures. In ... found in many healthcare settings, can be a ... the April issue of the American Journal of ... of 12 patients after refractive surgery. , These ...
... to weigh less than children who sleep less, and ... overweight five years later. That’s one of the major ... 2007 issue of the journal Child Development. , Conducted ... 2,281 children from a nationally representative survey called the ...
... $22.5 million research program at Iowa State University ... The grant is part of ConocoPhillips' plan to ... produce viable solutions to diversify America's energy sources. ... million grant in 2007 to support Iowa State ...
Cached Biology News:Drug-resistant bacterial infections serious complication after corrective eye surgery 2Children who sleep more weigh less 2ConocoPhillips establishes $22.5M biofuels research program at Iowa State 2ConocoPhillips establishes $22.5M biofuels research program at Iowa State 3
(Date:7/10/2014)... Toronto, Canada (PRWEB) July 10, 2014 ... often present in very low abundance and are ... quite challenging and time-consuming. , Join presenters Dr. ... Laboratories, and Dr. John Anders, Head of Quality ... mass spectrometer-based approach that can speed detection and ...
(Date:7/10/2014)... CA (PRWEB) July 10, 2014 Robert Harman, ... Veterinary Medicine company, is proud to announce the relaunch of ... launching with a new series called “ What are Stem ... give an honest and straightforward foundation in the basics of ... educated decision on the right type of treatment when considering ...
(Date:7/10/2014)... On July 9 Prime Minister ... Russia,s first national "Industry" award ... is developing a unique project called MabNext . ... number of innovative drugs based on monoclonal antibodies for ... place at the International Exhibition "Innoprom 2014" in Ekaterinburg. ...
(Date:7/10/2014)... 2014 -- According to the International Atomic Energy ... comes from terrorists acquiring sufficient quantities of plutonium ... crude nuclear explosive device. The IAEA also notes ... involved gram-level quantities, which can be challenging to ... a new study appearing this week in the ...
Breaking Biology Technology:Novel Ms Techniques Speed Detection of Biopharmaceutical Product and Process Impurities, New Webinar Hosted by Xtalks 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 3Dmitry Medvedev Presented BIOCAD the First National "Industry" Award 2Sensitive detection method may help impede illicit nuclear trafficking 2
... WASHINGTON , May 20 Today, world-renowned ... and his team at the J. Craig Venter Institute (JCVI) ... self-replicating cell.  The news holds groundbreaking potential for solutions to ... pharmaceuticals and vaccines; cleaning up pollution; creating new energy sources; ...
... ... University of California campuses -- San Francisco and Berkeley -- to jointly launch the first ... patient care. , ... 20, 2010 -- Former Intel Corp. chief executive Andy Grove has pledged $1.5 million to ...
... SAN FRANCISCO and WASHINGTON , ... Inc., a clinical-stage cancer biotherapeutics company, today reported positive ... the intravenous (IV) administration of JX-594 to patients with ... delivery to solid tumors, cancer-targeted replication and gene expression, ...
Cached Biology Technology:Science Channel Announces the Debut of Exclusive Look Into Dr. J. Craig Venter's Creation of Synthetic Life 2Science Channel Announces the Debut of Exclusive Look Into Dr. J. Craig Venter's Creation of Synthetic Life 3Grove Gift Launches Translational Medicine Program at UCSF & UC Berkeley 2Grove Gift Launches Translational Medicine Program at UCSF & UC Berkeley 3Grove Gift Launches Translational Medicine Program at UCSF & UC Berkeley 4Jennerex Reports Positive Phase 1 Results for JX-594 Administered Intravenously 2Jennerex Reports Positive Phase 1 Results for JX-594 Administered Intravenously 3Jennerex Reports Positive Phase 1 Results for JX-594 Administered Intravenously 4
... plus assay system offers the ... Designed for batch-processing systems, Long ... density microplates such as 384-well ... Convenient storage conditions ( 2 ...
... kit consists of universal lysis buffer, PCR ... for 100 25 l volume PCR reactions. ... Gram negative or positive rod and coccus ... Bacillus Cereus, Staphylococcus Aureus, Streptococcus Agalactiae, and ...
... The SilverQuest Silver Staining Kit ... silver staining sensitivity with minimal protein ... The mass spectrometry problems associated with ... the SilverQuest kit because the reagents ...
...
Biology Products: