Navigation Links
Tiny particles may help surgeons by marking brain tumors
Date:4/29/2010

COLUMBUS, Ohio - - Researchers have developed a way to enhance how brain tumors appear in MRI scans and during surgery, making the tumors easier for surgeons to identify and remove.

Scientists at Ohio State University are experimenting with different nanoparticles that they hope may one day be injected into the blood of patients and help surgeons remove lethal brain tumors known as glioblastomas.

In the journal Nanotechnology, researchers reported that they have manufactured a small particle called a nanocomposite that is both magnetic and fluorescent. These nanocomposites measure less than twenty nanometers in size (a nanometer is one billionth of a meter). One sheet of paper, for example, is about 100,000 nanometers thick.

"Our strategy is combining two particles that contain different properties to make one particle with multiple properties," explained Jessica Winter, assistant professor in chemical and biomolecular engineering and biomedical engineering at Ohio State.

The magnetic nanoparticles emphasize color contrasts within MRIs, allowing doctors to see potential or existing cancerous tumors before surgery. The fluorescent nanoparticles can change the color that the tumor appears in the brain when seen under a special light.

Neurological surgeons could benefit from a multi-functional particle that would allow them to better see the tumor with an MRI before surgery, and then see it physically during surgery, Winter said.

"We're trying to develop a single nanocomposite that's magnetic so you can do preoperative MRI and that's fluorescent so that when neurological surgeons go into surgery, they can shine a light on the tumor and it will glow a specific color such as green, for example. Then, the surgeon can simply remove all of the green," Winter said.

"With traditional magnetic contrasting agents, you'll get an MRI, but you won't see anything during surgery," she added.

Winter's study provided convincing proof that a particle with dual properties can be formed. However, these multi-functional particles can't be used for animal or human testing because the fluorescent particle, cadmium telluride, is toxic.

"We're currently working on an alternative fluorescent particle which is composed of carbon. This will eliminate the complications that arise with ingesting the cadmium telluride particles," Winter said.

Patients with a specific form of deadly brain tumor, glioblastoma, could benefit from Winter's work. Glioblastomas are usually located in the temporal, or frontal lobe of the brain, and tumors located there are difficult to see and remove.

Combining the two particles could provide doctors with help both before and during the surgery to remove a brain tumor, Winter said.

One of the successes in creating the new nanocomposite particle was how they did it, Winter said. It is normally difficult to combine particles like these, a process known as doping.

The Ohio State researchers pursued an approach which had not been attempted before. They chose to bind their fluorescent particle on top of their magnetic particle at extremely high temperatures.

The key is that our synthesis is done at pretty high temperatures about 350 degrees Celsius (around 660 degrees Fahrenheit)," Winter explained. "The synthesis was unexpected, but cool at the same time, and we were excited when we saw what we got."


'/>"/>

Contact: Jessica Winter
Winter.63@osu.edu
614-292-3769
Ohio State University
Source:Eurekalert

Related biology news :

1. U Alberta-led team studies T cell activation with nanoparticles
2. New method for recovering pricey nanoparticles
3. Caltech-led team provides proof in humans of RNA interference using targeted nanoparticles
4. Engineers: Weak laser can ignite nanoparticles, with exciting possibilities
5. Like little golden assassins, smart nanoparticles identify, target and kill cancer cells
6. Atmospheric nanoparticles impact health, weather professor says
7. Silver nanoparticles may one day be key to devices that keep hearts beating strong and steady
8. Magnetic nanoparticles show promise for combating human cancer
9. New nanoparticles target cardiovascular disease
10. Biodegradable particles can bypass mucus, release drugs over time
11. Tracking new cancer-killing particles with MRI
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/21/2017)... Ore. , Feb. 22, 2017  IBM (NYSE: ... (Avamere Health Services, Infinity Rehab, Signature Hospice, Home Health, ... will apply the power of IBM cognitive computing to ... centers. By analyzing data streaming from sensors in senior ... and environmental conditions, and obtain deeper learnings into the ...
(Date:2/13/2017)... FRANCISCO , Feb. 13, 2017  RSA ... centralized platform that is designed to enhance fraud ... latest release in the RSA Fraud & Risk ... enable organizations to leverage additional insights from internal ... tools to better protect their customers from targeted ...
(Date:2/8/2017)... YORK , Feb. 8, 2017 About ... individual,s voice to match it against a stored ... such as pitch, cadence, and tone are compared ... require minimal hardware installation, as most PCs already ... for different transactions. Voice recognition biometrics are most ...
Breaking Biology News(10 mins):
(Date:2/24/2017)... China Biologic Products, Inc. (NASDAQ: CBPO) ("China Biologic" or the ... today announced its financial results for the fourth quarter and ... Financial Highlights Total sales in the ... or increased by 13.6% in USD terms to $77.6 million ... Gross profit increased by 13.3% to $46.8 million ...
(Date:2/23/2017)... ... February 23, 2017 , ... BellBrook ... portfolio to include an array of biochemical analyses critical for Lead Discovery. ... their hit-to-lead and SAR programs, including inhibitor potency and selectivity, mechanism of action, ...
(Date:2/23/2017)... , Feb. 23, 2017  Imanis Life Sciences ... line of oncolytic vaccinia viruses for virotherapy research. ... part of Genelux,s proprietary, vaccinia virus-based technology platform ... to enter into a partnership with Genelux to ... vaccinia viruses for use in research," said Dr. ...
(Date:2/23/2017)... ... 2017 , ... The Greater Gift Initiative, Inc , (GGI) a Winston-Salem, ... . GGI's mission is to advance global health and highlight the greater good of ... of each clinical trial volunteer. The vision of GGI is to serve as a ...
Breaking Biology Technology: