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Tiny particles can deliver antioxidant enzyme to injured heart cells
Date:11/15/2009

y can induce inflammation.

Davis and his colleagues have also used the polyketal microparticles to encase anti-inflammatory drugs. This is the first report on the antioxidant enzyme-containing particles' use in a model of heart attack.

Emory and Georgia Tech scientists have also used SOD-containing particles to treat mice engineered to have a deficiency in SOD in the lung: http://www.ncbi.nlm.nih.gov/pubmed/18787098

Although the SOD particles had a protective effect when the heart was examined three days after the simulated heart attack, the beneficial effects weren't as strong three weeks later. The rats' hearts still had a 35 percent improvement compared to untreated animals, Davis says. Combining them with microparticles containing the anti-inflammatory drugs proved to provide an additional boost.

"This is likely because it is important to scavenge free radicals at early time points, but inflammation becomes more important later on," he says.


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Contact: Jennifer Johnson
jrjohn9@emory.edu
404-727-5696
Emory University
Source:Eurekalert  

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