Navigation Links
Tiny particles can deliver antioxidant enzyme to injured heart cells
Date:11/15/2009

Researchers at Emory University and the Georgia Institute of Technology have developed microscopic polymer beads that can deliver an antioxidant enzyme made naturally by the body into the heart.

Injecting the enzyme-containing particles into rats' hearts after a simulated heart attack reduced the number of dying cells and resulted in improved heart function days later.

Michael Davis, PhD, is presenting the results Sunday evening at the American Heart Association Scientific Sessions in Orlando. Davis is assistant professor in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University.

The enzyme in the particles, called superoxide dismutase (SOD), soaks up toxic free radicals produced when cells are deprived of blood during a heart attack. Previously scientists have tried injecting SOD by itself into injured animals, but it doesn't seem to last long enough in the body to have any beneficial effects.

"Our goal is to have a therapy to blunt the permanent damage of a heart attack and reduce the probability of heart failure later in life," Davis says. "This is a way to get extra amounts of a beneficial antioxidant protein to the cells that need it."

The simulated heart attacks caused a 20 percent decrease in the ability of the rats' hearts to pump blood that was completely prevented by the particles, he says.

The particles are made of a material called polyketals, developed by Niren Murthy, PhD, assistant professor of biomedical engineering at Georgia Tech and Emory. The polyketals encase the enzyme and are taken up by cells within the heart. There the particles slowly release the enzyme.

The microparticles break down into nontoxic components in the body -- an advantage over other biodegradable polymers like PLGA (polylactic-co-glycolic acid), already approved for use in sutures and grafts. When polymers such as PLGA are made into particles for drug delivery, they can induce inflammation.

Davis and his colleagues have also used the polyketal microparticles to encase anti-inflammatory drugs. This is the first report on the antioxidant enzyme-containing particles' use in a model of heart attack.

Emory and Georgia Tech scientists have also used SOD-containing particles to treat mice engineered to have a deficiency in SOD in the lung: http://www.ncbi.nlm.nih.gov/pubmed/18787098

Although the SOD particles had a protective effect when the heart was examined three days after the simulated heart attack, the beneficial effects weren't as strong three weeks later. The rats' hearts still had a 35 percent improvement compared to untreated animals, Davis says. Combining them with microparticles containing the anti-inflammatory drugs proved to provide an additional boost.

"This is likely because it is important to scavenge free radicals at early time points, but inflammation becomes more important later on," he says.


'/>"/>

Contact: Jennifer Johnson
jrjohn9@emory.edu
404-727-5696
Emory University
Source:Eurekalert  

Related biology news :

1. Behavior modification could ease concerns about nanoparticles
2. Knocking nanoparticles off the socks
3. Penn team uses self-assembly to make molecule-sized particles with patches of charge
4. Clemson bioengineer uses nanoparticles to target drugs
5. Do dust particles curb climate change?
6. Therapeutic nanoparticles give new meaning to sugar-coating medicine
7. Carbon nanoparticles toxic to adult fruit flies but benign to young
8. New insights into health and environmental effects of carbon nanoparticles
9. Facile synthesis of nanoparticles with multiple functions advanced in Singapore
10. University of Leicester researchers discover new fluorescent silicon nanoparticles
11. New nanoparticles could revolutionize therapeutic drug discovery
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Tiny particles can deliver antioxidant enzyme to injured heart cells
(Date:12/2/2016)... 1, 2016 The report "Biometric ... Future Technology (Iris Recognition System), Vehicle Type (Passenger ... Forecast to 2021", published by MarketsandMarkets, the market ... 2016, and is projected to grow to USD ... 14.06%.      (Logo: http://photos.prnewswire.com/prnh/20160303/792302) ...
(Date:11/29/2016)... Lithuania , Nov. 29, 2016 /PRNewswire/ ... biometric identification and object recognition technologies, today ... (SDK) for fingerprint recognition solutions that run ... a fingerprint template using less than 128KB ... in compact devices that have limited on-board ...
(Date:11/22/2016)... MINNETONKA, Minn. , Nov. 22, 2016   ... that supports the entire spectrum of clinical research, is ... by Medical LiveWire Healthcare and Life Sciences Awards ... This award caps off an unprecedented year of recognition ... clinical trials for over 15 years. iMedNet ...
Breaking Biology News(10 mins):
(Date:12/8/2016)... BARCELONA, Spain , Dec. 8, 2016  Anaconda ... on the development of the next generation neuro-thrombectomy system ... the appointment of Tudor G. Jovin, MD to join ... to serve as a strategic network of scientific and ... progresses the development of the ANCD BRAIN ® ...
(Date:12/8/2016)... CA (PRWEB) , ... December 08, 2016 , ... ... as finalists in the World Technology Awards. uBiome is one of just six ... across all categories. , In addition to uBiome, companies nominated as finalists in ...
(Date:12/8/2016)... Dec. 8, 2016 Soligenix, Inc. (OTCQB: SNGX) ... on developing and commercializing products to treat rare diseases ... that it will be hosting an Investor Webcast Event ... the origins of innate defense regulators (IDRs) as a ... oral mucositis and the recently announced and published Phase ...
(Date:12/8/2016)... Eutilex Co. Ltd. today announced that it ... A financing. This financing round included participation from DS ... Bio Angel. This new funding brings the total capital ... since its founding in 2015. The ... commercialization of its immuno-oncology programs, expand its R&D capabilities ...
Breaking Biology Technology: