Navigation Links
Tiny molecules protect from the dangers of sex
Date:11/14/2010

DURHAM, N.C. Pathogenic fungi have been found to protect themselves against unwanted genetic mutations during sexual reproduction, according to researchers at Duke University Medical Center. A gene-silencing pathway protects the fungal genome from mutations imposed by a partner during mating.

This pathway was discovered in Cryptococcus neoformans, a fungus that commonly infects humans, causing over one million cases of lung and brain infection each year, and more than 600,000 deaths. A related species, Cryptococcus gattii, is causing an expanding outbreak in the Pacific Northwest that is of considerable public health impact and concern.

"This discovery of how the genome is protected during sex might be leveraged as an Achilles' heel in the battle against C. neoformans, which frequently causes life-threatening illness in people," said senior author Joseph Heitman, M.D., Ph.D., chair of the Duke Department of Molecular Genetics and Microbiology. "This protective silencing effect also operates in some animals, and our studies demonstrate that the pathway operates to defend the genome during sexual reproduction."

Sexual reproduction in fungi produces airborne spores that are readily inhaled into the lungs and thought to be the source of human infections. Thus, agents that block fungal sex might stop the risk of infection at the source.

This work was published in the Nov. 15 issue of the journal Genes & Development.

C. neoformans uses a novel sex-induced RNAi (RNA interference) genome defense system that protects by effectively "silencing" the DNA, so that it is not vulnerable to repeated genes and transposable elements that could cause mutations.

The silencing system protects the genome from changes that might be imposed by transposable elements of DNA, called "jumping genes," that are also more active during the sexual cycle, said Xuying Wang, Ph.D., a postdoctoral associate who works in the Heitman l
'/>"/>

Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Of 50,000 small molecules tested to fight cancer, 2 show promise
2. Study identifies key molecules in multiple myeloma
3. New class of biomolecules triggered in response to respiratory virus infection
4. Scientists trick bacteria with small molecules
5. MIT researchers develop a better way to see molecules at work in living brain cells
6. Scientists identify molecules involved in touch and other mechanically activated systems
7. Juelich researchers take a look inside molecules
8. Molecules delivering drugs as they walk
9. Nanoblasts from laser-activated nanoparticles move molecules, proteins and DNA into cells
10. Correcting a trick of the light brings molecules into view
11. Molecules typically found in blue jean and ink dyes may lead to more efficient solar cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... SHENZHEN , Chine, 31 juillet 2015 /PRNewswire/ ... (ICG-10, www.icg-10.org ) sera organisée par le ... Shenzhen en Chine. ... année. Depuis son inauguration en 2006, l,ICG est ... influentes dans le domaine des « omiques » et c,est ...
(Date:7/31/2015)... July 31, 2015 The 10 th International ... by BGI from October 22-25, 2015, in Shenzhen ... conference is celebrating its 10 th anniversary this year. Since ... world,s most influential annual meetings in the ,omics, fields, and ... gatherings. ICG-10 focuses on recent breakthroughs and ...
(Date:7/23/2015)... 2015 Aware, Inc. (NASDAQ: AWRE ), a ... results for its second quarter ended June 30, 2015.  ... $4.5 million, a decrease of 33% compared to $6.8 million ... second quarter of 2015 was $0.3 million, or $0.01 per ... diluted share, in the same period a year ago.  ...
Breaking Biology News(10 mins):La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 2La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 3The 10th International Conference on Genomics (ICG-10) to Open in October 2Aware, Inc. Reports Second Quarter 2015 Financial Results 2Aware, Inc. Reports Second Quarter 2015 Financial Results 3Aware, Inc. Reports Second Quarter 2015 Financial Results 4Aware, Inc. Reports Second Quarter 2015 Financial Results 5Aware, Inc. Reports Second Quarter 2015 Financial Results 6
... not all plant-eating fish are created equal. A ... early edition of the journal Proceedings of the ... proper balance of herbivorous fishes may be critical to ... The conclusion results from a long-term study that found ...
... comparisons of its kind, researchers have demonstrated that wetlands in ... 80 percent more carbon than can wetlands in temperate zones. ... Rica and in Ohio and analyzed the contents of the ... they estimated that the tropical wetland accumulated a little over ...
... N.Y. (Oct. 7, 2008) A new, ... has just been released by Cold Spring Harbor ... in the laboratory, it includes essential step-wise protocols ... and troubleshooting advice on the most fundamental protein-related ...
Cached Biology News:Diversity of plant-eating fishes may be key to recovery of coral reefs 2Diversity of plant-eating fishes may be key to recovery of coral reefs 3Diversity of plant-eating fishes may be key to recovery of coral reefs 4Study: Tropical wetlands hold more carbon than temperate marshes 2Study: Tropical wetlands hold more carbon than temperate marshes 3New lab manual focuses on essential methods for purifying and characterizing proteins 2
(Date:7/30/2015)... customers across the globe, ISN improves the efficiency and effectiveness of contractor management systems. ... and reliable contractors in over 80 countries. ... ... Over 60,000 Worldwide Customers In More Than 80 Countries ... Headquartered in Dallas, TX , ISN has additional offices in ...
(Date:7/30/2015)... , ... July 30, 2015 , ... As part of its 2015 growth plan and ... and technical service business units, Whitehouse Laboratories is pleased to announce that it ... to the Container Center of Excellence and will be strictly dedicated to basic USP 51, ...
(Date:7/29/2015)... According to a new market research ... Forecasts (2015-2020), , published by Mordor Intelligence, the Global market ... end of 2020, with North America ... of the global market size. The Global market for Stem ... during the period of (2015-2020).      (Logo: http://photos.prnewswire.com/prnh/20150428/740799) ...
(Date:7/29/2015)... 2015  HealthSouth Corporation (NYSE: HLS ... post-acute healthcare services, offering both facility-based and home-based ... for the second quarter ended June 30, 2015. ... strong volume growth in both segments and an ... Grinney, President and Chief Executive Officer of HealthSouth. ...
Breaking Biology Technology:ISN Reaches Over 60,000 Worldwide Customers 2ISN Reaches Over 60,000 Worldwide Customers 3Whitehouse Labs Formally Announces Plans to Open a Microbiological Laboratory 2Asia Pacific to Dominate the Global Stem Cell Market - Vericel Corporation, Ocata Therpeutics, Athersys Inc., Cryo-Cell International, Geron Corporation, StemCells, Inc. Among the Major Players 2Asia Pacific to Dominate the Global Stem Cell Market - Vericel Corporation, Ocata Therpeutics, Athersys Inc., Cryo-Cell International, Geron Corporation, StemCells, Inc. Among the Major Players 3HealthSouth Reports Results for Second Quarter 2015 2HealthSouth Reports Results for Second Quarter 2015 3HealthSouth Reports Results for Second Quarter 2015 4HealthSouth Reports Results for Second Quarter 2015 5HealthSouth Reports Results for Second Quarter 2015 6HealthSouth Reports Results for Second Quarter 2015 7HealthSouth Reports Results for Second Quarter 2015 8HealthSouth Reports Results for Second Quarter 2015 9HealthSouth Reports Results for Second Quarter 2015 10HealthSouth Reports Results for Second Quarter 2015 11HealthSouth Reports Results for Second Quarter 2015 12HealthSouth Reports Results for Second Quarter 2015 13HealthSouth Reports Results for Second Quarter 2015 14HealthSouth Reports Results for Second Quarter 2015 15HealthSouth Reports Results for Second Quarter 2015 16HealthSouth Reports Results for Second Quarter 2015 17HealthSouth Reports Results for Second Quarter 2015 18HealthSouth Reports Results for Second Quarter 2015 19HealthSouth Reports Results for Second Quarter 2015 20HealthSouth Reports Results for Second Quarter 2015 21HealthSouth Reports Results for Second Quarter 2015 22HealthSouth Reports Results for Second Quarter 2015 23HealthSouth Reports Results for Second Quarter 2015 24HealthSouth Reports Results for Second Quarter 2015 25HealthSouth Reports Results for Second Quarter 2015 26HealthSouth Reports Results for Second Quarter 2015 27HealthSouth Reports Results for Second Quarter 2015 28HealthSouth Reports Results for Second Quarter 2015 29HealthSouth Reports Results for Second Quarter 2015 30HealthSouth Reports Results for Second Quarter 2015 31
... , CHICAGO, June 1 UCB, Inc. and ... recipients of the 2009 Research Awards in Inflammatory Bowel Disease ... one-year research grant for their original clinical or basic research, ... by the CDWG Steering Committee and the awards were funded ...
... KVISTGAARD, Denmark, June 1 Detailed data from,a ... the,ASCO Annual Meeting in Orlando. The presentation was made by ... and the Dana-Farber Cancer,Institute who is also the principal investigator ... detailed analysis supports the headline data that were reported,in October ...
... June 1 Pharmacyclics, Inc. (Nasdaq: PCYC ) ... S-3 with the Securities and Exchange Commission (the "SEC") for ... offering will be made through the distribution of non-transferable subscription ... value $0.0001 per share, at a subscription price to be ...
Cached Biology Technology:UCB and Crohn's Disease Working Group Award $175,000 in Research Grants to Gastroenterology Fellows 2PROSTVAC(TM) Data Presented at the ASCO Meeting Demonstrates the Potential for Significant Increases in Life Expectancy in Late-Stage Prostate Cancer 2PROSTVAC(TM) Data Presented at the ASCO Meeting Demonstrates the Potential for Significant Increases in Life Expectancy in Late-Stage Prostate Cancer 3Pharmacyclics Files Registration Statement for Rights Offering 2Pharmacyclics Files Registration Statement for Rights Offering 3Pharmacyclics Files Registration Statement for Rights Offering 4
Recombinant Rat Leptin, CF...
Adhesive seal-tab, for HybriWell™ hybridization sealing system *set of 400*...
... culture systems provide an integrated set-up ... and imaging. Each system uses medical-grade ... coverslips in cell culture plates. The ... ready to use. Individual chambered coverslips ...
RECOMBINANT EQUINE IL-4 Product Type: Recombinant Protein...
Biology Products: